ID   LEP_MELGA               Reviewed;         145 AA.
AC   O93416;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Leptin;
DE   AltName: Full=Obesity factor;
DE   Flags: Fragment;
GN   Name=LEP; Synonyms=OB;
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BIG 6 ML TOM; TISSUE=Liver;
RA   Ashwell C.M., Czerwinski S.M., McMurtry J.P.;
RT   "Turkey leptin (ob) mRNA, partial cds.";
RL   Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key player in the regulation of energy balance and body
CC       weight control. Once released into the circulation, has central and
CC       peripheral effects by binding LEPR, found in many tissues, which
CC       results in the activation of several major signaling pathways.
CC       {ECO:0000250|UniProtKB:P41159}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the leptin family. {ECO:0000305}.
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DR   EMBL; AF082501; AAC32381.1; -; mRNA.
DR   AlphaFoldDB; O93416; -.
DR   SMR; O93416; -.
DR   InParanoid; O93416; -.
DR   Proteomes; UP000001645; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISS:AgBase.
DR   GO; GO:0006909; P:phagocytosis; ISS:UniProtKB.
DR   GO; GO:2000866; P:positive regulation of estradiol secretion; ISS:AgBase.
DR   GO; GO:2000196; P:positive regulation of female gonad development; ISS:AgBase.
DR   GO; GO:0032735; P:positive regulation of interleukin-12 production; ISS:UniProtKB.
DR   GO; GO:0032755; P:positive regulation of interleukin-6 production; ISS:UniProtKB.
DR   GO; GO:0033686; P:positive regulation of luteinizing hormone secretion; ISS:AgBase.
DR   GO; GO:2000872; P:positive regulation of progesterone secretion; ISS:AgBase.
DR   GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000065; Leptin.
DR   PANTHER; PTHR11724; PTHR11724; 1.
DR   Pfam; PF02024; Leptin; 1.
DR   PIRSF; PIRSF001837; Leptin; 1.
DR   PRINTS; PR00495; LEPTIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Obesity; Reference proteome; Secreted.
FT   CHAIN           1..145
FT                   /note="Leptin"
FT                   /id="PRO_0000017693"
FT   DISULFID        95..145
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   145 AA;  15879 MW;  0F7B806A3FF1A384 CRC64;
     VPCQIFQDDT KTLIKTIVTR INDISHTSVS AKQSVTGLDF IPGLHPILSL SKMDQTLAVY
     QQVLTSLPSQ NVLQIANDLE NLRDLLHLLA FSKSCSLPQT SGLHKPESLD GVLEALLYST
     EVVALSRLQG SLQDILQQLD ISPEC