ARFE_ARATH
ID ARFE_ARATH Reviewed; 902 AA.
AC P93024; A5YYU1; A5YYU8; A5YYW1; A5YYW2; O64965; Q33DU8; Q9FXI3;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 3.
DT 03-AUG-2022, entry version 172.
DE RecName: Full=Auxin response factor 5;
DE AltName: Full=Auxin-responsive protein IAA24;
DE AltName: Full=Transcription factor MONOPTEROS;
GN Name=ARF5; Synonyms=IAA24, MP; OrderedLocusNames=At1g19850;
GN ORFNames=F6F9.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANT ILE-796.
RC STRAIN=cv. Columbia;
RX PubMed=9482737; DOI=10.1093/emboj/17.5.1405;
RA Hardtke C.S., Berleth T.;
RT "The Arabidopsis gene MONOPTEROS encodes a transcription factor mediating
RT embryo axis formation and vascular development.";
RL EMBO J. 17:1405-1411(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-75.
RC STRAIN=cv. Columbia;
RX PubMed=16227452; DOI=10.1105/tpc.105.036533;
RA Nishimura T., Wada T., Yamamoto K.T., Okada K.;
RT "The Arabidopsis STV1 protein, responsible for translation reinitiation, is
RT required for auxin-mediated gynoecium patterning.";
RL Plant Cell 17:2940-2953(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 13-902.
RC STRAIN=cv. Columbia;
RX PubMed=9342315; DOI=10.1073/pnas.94.22.11786;
RA Kim J., Harter K., Theologis A.;
RT "Protein-protein interactions among the Aux/IAA proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:11786-11791(1997).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 422-690, AND VARIANTS PHE-439; THR-526
RP AND GLY-539--542-SER DEL.
RC STRAIN=cv. Ag-0, cv. An-1, cv. Br-0, cv. C24, cv. Ct-1, cv. Cvi-1,
RC cv. Edi-0, cv. Ga-0, cv. Kas-1, cv. Kin-0, cv. Landsberg erecta, cv. Ll-0,
RC cv. Lz-0, cv. Ms-0, cv. Mt-0, cv. Nd-1, cv. Nok-3, cv. Oy-0, cv. Se-0,
RC cv. Sorbo, cv. Tsu-1, cv. Van-0, cv. Wa-1, and cv. Wassilewskija;
RX PubMed=17435248; DOI=10.1534/genetics.107.071928;
RA Ehrenreich I.M., Stafford P.A., Purugganan M.D.;
RT "The genetic architecture of shoot branching in Arabidopsis thaliana: a
RT comparative assessment of candidate gene associations vs. quantitative
RT trait locus mapping.";
RL Genetics 176:1223-1236(2007).
RN [8]
RP DIMERIZATION, AND TISSUE SPECIFICITY.
RX PubMed=10476078; DOI=10.1046/j.1365-313x.1999.00538.x;
RA Ulmasov T., Hagen G., Guilfoyle T.J.;
RT "Dimerization and DNA binding of auxin response factors.";
RL Plant J. 19:309-319(1999).
RN [9]
RP TRANSCRIPTIONAL ACTIVATOR.
RX PubMed=10318972; DOI=10.1073/pnas.96.10.5844;
RA Ulmasov T., Hagen G., Guilfoyle T.J.;
RT "Activation and repression of transcription by auxin-response factors.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:5844-5849(1999).
RN [10]
RP INTERACTION WITH BODENLOS.
RX PubMed=12101120; DOI=10.1101/gad.229402;
RA Hamann T., Benkova E., Baeurle I., Kientz M., Juergens G.;
RT "The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting
RT MONOPTEROS-mediated embryo patterning.";
RL Genes Dev. 16:1610-1615(2002).
RN [11]
RP GENE FAMILY, NOMENCLATURE, AND FUNCTION.
RX PubMed=12036261; DOI=10.1023/a:1015207114117;
RA Hagen G., Guilfoyle T.J.;
RT "Auxin-responsive gene expression: genes, promoters and regulatory
RT factors.";
RL Plant Mol. Biol. 49:373-385(2002).
RN [12]
RP FUNCTION, SUBUNIT, AND INTERACTION WITH ARF7.
RX PubMed=14973283; DOI=10.1242/dev.00925;
RA Hardtke C.S., Ckurshumova W., Vidaurre D.P., Singh S.A., Stamatiou G.,
RA Tiwari S.B., Hagen G., Guilfoyle T.J., Berleth T.;
RT "Overlapping and non-redundant functions of the Arabidopsis auxin response
RT factors MONOPTEROS and NONPHOTOTROPIC HYPOCOTYL 4.";
RL Development 131:1089-1100(2004).
RN [13]
RP FUNCTION.
RX PubMed=17553903; DOI=10.1242/dev.006759;
RA Vidaurre D.P., Ploense S., Krogan N.T., Berleth T.;
RT "AMP1 and MP antagonistically regulate embryo and meristem development in
RT Arabidopsis.";
RL Development 134:2561-2567(2007).
RN [14]
RP GENE FAMILY.
RX PubMed=18986826; DOI=10.1016/j.tplants.2008.09.006;
RA Swaminathan K., Peterson K., Jack T.;
RT "The plant B3 superfamily.";
RL Trends Plant Sci. 13:647-655(2008).
RN [15]
RP INTERACTION WITH BRX.
RX PubMed=19465596; DOI=10.1242/dev.035444;
RA Scacchi E., Osmont K.S., Beuchat J., Salinas P., Navarrete-Gomez M.,
RA Trigueros M., Ferrandiz C., Hardtke C.S.;
RT "Dynamic, auxin-responsive plasma membrane-to-nucleus movement of
RT Arabidopsis BRX.";
RL Development 136:2059-2067(2009).
CC -!- FUNCTION: Auxin response factors (ARFs) are transcriptional factors
CC that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the
CC auxin-responsive promoter elements (AuxREs). Seems to act as
CC transcriptional activator. Formation of heterodimers with Aux/IAA
CC proteins may alter their ability to modulate early auxin response genes
CC expression. Mediates embryo axis formation and vascular tissues
CC differentiation. Functionally redundant with ARF7. May be necessary to
CC counteract AMP1 activity. {ECO:0000269|PubMed:12036261,
CC ECO:0000269|PubMed:14973283, ECO:0000269|PubMed:17553903}.
CC -!- SUBUNIT: Homodimers and heterodimers. Interacts with BRX and the auxin-
CC responsive proteins IAA1, IAA12 (BODENLOS), IAA17 and ARF7.
CC {ECO:0000269|PubMed:12101120, ECO:0000269|PubMed:14973283,
CC ECO:0000269|PubMed:19465596}.
CC -!- INTERACTION:
CC P93024; P93024: ARF5; NbExp=5; IntAct=EBI-629519, EBI-629519;
CC P93024; P49677: IAA1; NbExp=4; IntAct=EBI-629519, EBI-630505;
CC P93024; Q38830: IAA12; NbExp=4; IntAct=EBI-629519, EBI-617608;
CC P93024; Q38831: IAA13; NbExp=3; IntAct=EBI-629519, EBI-1554143;
CC P93024; Q38832: IAA14; NbExp=3; IntAct=EBI-629519, EBI-2295562;
CC P93024; O24409: IAA19; NbExp=4; IntAct=EBI-629519, EBI-632257;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Expressed in the whole plant with a lower
CC expression in leaves. Detected in embryo axis, provascular tissues,
CC procambium and some differentiated vascular regions of mature organs.
CC {ECO:0000269|PubMed:10476078}.
CC -!- DEVELOPMENTAL STAGE: In early embryo and during organ development.
CC -!- DOMAIN: Interactions between auxin response factors (ARFs) and Aux/IAA
CC proteins occur through their C-terminal dimerization domains III and
CC IV.
CC -!- MISCELLANEOUS: Absence of the protein probably causes early embryonic
CC lethality. Premature stop codons are associated with vascular defects.
CC -!- SIMILARITY: Belongs to the ARF family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG12546.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF037228; AAC39410.1; -; Genomic_DNA.
DR EMBL; AF037229; AAC60794.1; -; mRNA.
DR EMBL; AC007797; AAG12546.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29906.1; -; Genomic_DNA.
DR EMBL; AF334716; AAG50094.1; -; mRNA.
DR EMBL; BT002050; AAN72061.1; -; mRNA.
DR EMBL; BT008805; AAP68244.1; -; mRNA.
DR EMBL; AB199792; BAE48152.1; -; mRNA.
DR EMBL; U79557; AAB92476.1; -; mRNA.
DR EMBL; EF598523; ABR09007.1; -; Genomic_DNA.
DR EMBL; EF598524; ABR09008.1; -; Genomic_DNA.
DR EMBL; EF598525; ABR09009.1; -; Genomic_DNA.
DR EMBL; EF598526; ABR09010.1; -; Genomic_DNA.
DR EMBL; EF598527; ABR09011.1; -; Genomic_DNA.
DR EMBL; EF598528; ABR09012.1; -; Genomic_DNA.
DR EMBL; EF598529; ABR09013.1; -; Genomic_DNA.
DR EMBL; EF598530; ABR09014.1; -; Genomic_DNA.
DR EMBL; EF598531; ABR09015.1; -; Genomic_DNA.
DR EMBL; EF598532; ABR09016.1; -; Genomic_DNA.
DR EMBL; EF598533; ABR09017.1; -; Genomic_DNA.
DR EMBL; EF598534; ABR09018.1; -; Genomic_DNA.
DR EMBL; EF598535; ABR09019.1; -; Genomic_DNA.
DR EMBL; EF598536; ABR09020.1; -; Genomic_DNA.
DR EMBL; EF598537; ABR09021.1; -; Genomic_DNA.
DR EMBL; EF598538; ABR09022.1; -; Genomic_DNA.
DR EMBL; EF598539; ABR09023.1; -; Genomic_DNA.
DR EMBL; EF598540; ABR09024.1; -; Genomic_DNA.
DR EMBL; EF598541; ABR09025.1; -; Genomic_DNA.
DR EMBL; EF598542; ABR09026.1; -; Genomic_DNA.
DR EMBL; EF598543; ABR09027.1; -; Genomic_DNA.
DR EMBL; EF598544; ABR09028.1; -; Genomic_DNA.
DR EMBL; EF598545; ABR09029.1; -; Genomic_DNA.
DR EMBL; EF598546; ABR09030.1; -; Genomic_DNA.
DR PIR; G86331; G86331.
DR PIR; T51807; T51807.
DR RefSeq; NP_173414.1; NM_101840.3.
DR PDB; 4CHK; X-ray; 2.85 A; A/B/C/D/E/F/G/H=779-902.
DR PDB; 4LDU; X-ray; 2.15 A; A=1-390.
DR PDB; 6L5K; X-ray; 2.91 A; A=788-885.
DR PDBsum; 4CHK; -.
DR PDBsum; 4LDU; -.
DR PDBsum; 6L5K; -.
DR AlphaFoldDB; P93024; -.
DR SMR; P93024; -.
DR BioGRID; 23812; 38.
DR IntAct; P93024; 36.
DR STRING; 3702.AT1G19850.1; -.
DR iPTMnet; P93024; -.
DR MetOSite; P93024; -.
DR PaxDb; P93024; -.
DR PRIDE; P93024; -.
DR ProteomicsDB; 246991; -.
DR EnsemblPlants; AT1G19850.1; AT1G19850.1; AT1G19850.
DR GeneID; 838573; -.
DR Gramene; AT1G19850.1; AT1G19850.1; AT1G19850.
DR KEGG; ath:AT1G19850; -.
DR Araport; AT1G19850; -.
DR TAIR; locus:2035454; AT1G19850.
DR eggNOG; ENOG502QQ0Y; Eukaryota.
DR HOGENOM; CLU_002626_2_1_1; -.
DR InParanoid; P93024; -.
DR OrthoDB; 155049at2759; -.
DR PhylomeDB; P93024; -.
DR PRO; PR:P93024; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; P93024; baseline and differential.
DR Genevisible; P93024; AT.
DR GO; GO:0005634; C:nucleus; ISS:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:TAIR.
DR GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0009793; P:embryo development ending in seed dormancy; IGI:TAIR.
DR GO; GO:0009908; P:flower development; IGI:TAIR.
DR GO; GO:0010305; P:leaf vascular tissue pattern formation; IGI:TAIR.
DR GO; GO:0009942; P:longitudinal axis specification; IMP:TAIR.
DR GO; GO:0048507; P:meristem development; IGI:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEP:TAIR.
DR GO; GO:0009733; P:response to auxin; IEP:TAIR.
DR GO; GO:0048364; P:root development; IGI:TAIR.
DR GO; GO:0010051; P:xylem and phloem pattern formation; IMP:TAIR.
DR CDD; cd10017; B3_DNA; 1.
DR Gene3D; 2.40.330.10; -; 1.
DR InterPro; IPR010525; ARF_dom.
DR InterPro; IPR044835; ARF_plant.
DR InterPro; IPR033389; AUX/IAA_dom.
DR InterPro; IPR003340; B3_DNA-bd.
DR InterPro; IPR015300; DNA-bd_pseudobarrel_sf.
DR InterPro; IPR000270; PB1_dom.
DR PANTHER; PTHR31384; PTHR31384; 1.
DR Pfam; PF02309; AUX_IAA; 1.
DR Pfam; PF06507; Auxin_resp; 1.
DR Pfam; PF02362; B3; 1.
DR SMART; SM01019; B3; 1.
DR SUPFAM; SSF101936; SSF101936; 1.
DR PROSITE; PS50863; B3; 1.
DR PROSITE; PS51745; PB1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Activator; Auxin signaling pathway; Developmental protein;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..902
FT /note="Auxin response factor 5"
FT /id="PRO_0000111509"
FT DOMAIN 793..877
FT /note="PB1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01081"
FT DNA_BIND 158..260
FT /note="TF-B3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00326"
FT REGION 497..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 439
FT /note="Y -> F (in strain; cv. Ag-0)"
FT /evidence="ECO:0000269|PubMed:17435248"
FT VARIANT 526
FT /note="M -> T (in strain: cv. Cvi-1)"
FT /evidence="ECO:0000269|PubMed:17435248"
FT VARIANT 539..542
FT /note="Missing (in strain: cv. Kas-1)"
FT VARIANT 796
FT /note="T -> I"
FT /evidence="ECO:0000269|PubMed:9482737"
FT HELIX 53..60
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 72..75
FT /evidence="ECO:0007829|PDB:4LDU"
FT HELIX 77..88
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 104..117
FT /evidence="ECO:0007829|PDB:4LDU"
FT TURN 119..121
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 124..132
FT /evidence="ECO:0007829|PDB:4LDU"
FT HELIX 136..138
FT /evidence="ECO:0007829|PDB:4LDU"
FT HELIX 142..145
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 155..161
FT /evidence="ECO:0007829|PDB:4LDU"
FT TURN 165..167
FT /evidence="ECO:0007829|PDB:4LDU"
FT TURN 169..171
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 173..175
FT /evidence="ECO:0007829|PDB:4LDU"
FT HELIX 177..183
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 191..193
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 195..201
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 207..215
FT /evidence="ECO:0007829|PDB:4LDU"
FT TURN 216..219
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 220..223
FT /evidence="ECO:0007829|PDB:4LDU"
FT HELIX 227..234
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 241..246
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 252..257
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 269..271
FT /evidence="ECO:0007829|PDB:4LDU"
FT HELIX 273..290
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 294..298
FT /evidence="ECO:0007829|PDB:4LDU"
FT TURN 300..302
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 308..310
FT /evidence="ECO:0007829|PDB:4LDU"
FT HELIX 311..317
FT /evidence="ECO:0007829|PDB:4LDU"
FT TURN 318..320
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 328..334
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 340..350
FT /evidence="ECO:0007829|PDB:4LDU"
FT TURN 355..357
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 366..371
FT /evidence="ECO:0007829|PDB:4LDU"
FT TURN 374..376
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 380..382
FT /evidence="ECO:0007829|PDB:4LDU"
FT HELIX 384..386
FT /evidence="ECO:0007829|PDB:4LDU"
FT STRAND 795..800
FT /evidence="ECO:0007829|PDB:4CHK"
FT STRAND 805..808
FT /evidence="ECO:0007829|PDB:4CHK"
FT HELIX 810..812
FT /evidence="ECO:0007829|PDB:4CHK"
FT STRAND 813..815
FT /evidence="ECO:0007829|PDB:6L5K"
FT HELIX 816..827
FT /evidence="ECO:0007829|PDB:4CHK"
FT TURN 830..832
FT /evidence="ECO:0007829|PDB:4CHK"
FT TURN 836..838
FT /evidence="ECO:0007829|PDB:4CHK"
FT STRAND 842..847
FT /evidence="ECO:0007829|PDB:4CHK"
FT STRAND 852..854
FT /evidence="ECO:0007829|PDB:4CHK"
FT HELIX 860..866
FT /evidence="ECO:0007829|PDB:4CHK"
FT STRAND 867..873
FT /evidence="ECO:0007829|PDB:4CHK"
FT HELIX 875..889
FT /evidence="ECO:0007829|PDB:4CHK"
SQ SEQUENCE 902 AA; 99650 MW; D20D348369757F09 CRC64;
MMASLSCVED KMKTSCLVNG GGTITTTTSQ STLLEEMKLL KDQSGTRKPV INSELWHACA
GPLVCLPQVG SLVYYFSQGH SEQVAVSTRR SATTQVPNYP NLPSQLMCQV HNVTLHADKD
SDEIYAQMSL QPVHSERDVF PVPDFGMLRG SKHPTEFFCK TLTASDTSTH GGFSVPRRAA
EKLFPPLDYS AQPPTQELVV RDLHENTWTF RHIYRGQPKR HLLTTGWSLF VGSKRLRAGD
SVLFIRDEKS QLMVGVRRAN RQQTALPSSV LSADSMHIGV LAAAAHATAN RTPFLIFYNP
RACPAEFVIP LAKYRKAICG SQLSVGMRFG MMFETEDSGK RRYMGTIVGI SDLDPLRWPG
SKWRNLQVEW DEPGCNDKPT RVSPWDIETP ESLFIFPSLT SGLKRQLHPS YFAGETEWGS
LIKRPLIRVP DSANGIMPYA SFPSMASEQL MKMMMRPHNN QNVPSFMSEM QQNIVMGNGG
LLGDMKMQQP LMMNQKSEMV QPQNKLTVNP SASNTSGQEQ NLSQSMSAPA KPENSTLSGC
SSGRVQHGLE QSMEQASQVT TSTVCNEEKV NQLLQKPGAS SPVQADQCLD ITHQIYQPQS
DPINGFSFLE TDELTSQVSS FQSLAGSYKQ PFILSSQDSS AVVLPDSTNS PLFHDVWDTQ
LNGLKFDQFS PLMQQDLYAS QNICMSNSTT SNILDPPLSN TVLDDFCAIK DTDFQNHPSG
CLVGNNNTSF AQDVQSQITS ASFADSQAFS RQDFPDNSGG TGTSSSNVDF DDCSLRQNSK
GSSWQKIATP RVRTYTKVQK TGSVGRSIDV TSFKDYEELK SAIECMFGLE GLLTHPQSSG
WKLVYVDYES DVLLVGDDPW EEFVGCVRCI RILSPTEVQQ MSEEGMKLLN SAGINDLKTS
VS
