ID   LEP_TAKRU               Reviewed;         152 AA.
AC   Q588G0;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Leptin;
DE   Flags: Precursor;
GN   Name=lep;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Liver;
RX   PubMed=15808904; DOI=10.1016/j.peptides.2004.12.017;
RA   Kurokawa T., Uji S., Suzuki T.;
RT   "Identification of cDNA coding for a homologue to mammalian leptin from
RT   pufferfish, Takifugu rubripes.";
RL   Peptides 26:745-750(2005).
CC   -!- FUNCTION: May function as part of a signaling pathway that acts to
CC       regulate the size of the body fat depot. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed mostly in the liver.
CC       {ECO:0000269|PubMed:15808904}.
CC   -!- SIMILARITY: Belongs to the leptin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB193547; BAD94444.1; -; mRNA.
DR   RefSeq; NP_001027897.1; NM_001032725.1.
DR   AlphaFoldDB; Q588G0; -.
DR   SMR; Q588G0; -.
DR   STRING; 31033.ENSTRUP00000034085; -.
DR   Ensembl; ENSTRUT00000034211; ENSTRUP00000034085; ENSTRUG00000022248.
DR   GeneID; 548631; -.
DR   KEGG; tru:548631; -.
DR   CTD; 3952; -.
DR   GeneTree; ENSGT00530000066614; -.
DR   HOGENOM; CLU_1643161_0_0_1; -.
DR   InParanoid; Q588G0; -.
DR   OMA; RQGHCSE; -.
DR   OrthoDB; 1317008at2759; -.
DR   Proteomes; UP000005226; Chromosome 9.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Obesity; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..152
FT                   /note="Leptin"
FT                   /id="PRO_0000042928"
FT   DISULFID        109..152
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   152 AA;  17204 MW;  4CE6B3227801A4B1 CRC64;
     MDHILALVLA LLPLSLCVAL PGALDAMDVE KMKSKVTWKA QGLVARIDKH FPDRGLRFDT
     DKVEGSTSVV ASLESYNNLI SDRFGGVSQI KTEISSLAGY LNHWREGNCQ EQQPKVWPRR
     NIFNHTVSLE ALMRVREFLK LLQKNVDLLE RC