ID   LEP_TETNG               Reviewed;         160 AA.
AC   Q588F8;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 2.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Leptin;
DE   Flags: Precursor;
GN   Name=lep;
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=15808904; DOI=10.1016/j.peptides.2004.12.017;
RA   Kurokawa T., Uji S., Suzuki T.;
RT   "Identification of cDNA coding for a homologue to mammalian leptin from
RT   pufferfish, Takifugu rubripes.";
RL   Peptides 26:745-750(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
CC   -!- FUNCTION: May function as part of a signaling pathway that acts to
CC       regulate the size of the body fat depot. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the leptin family. {ECO:0000305}.
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DR   EMBL; AB193549; BAD94451.1; -; mRNA.
DR   EMBL; CAAE01015035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q588F8; -.
DR   SMR; Q588F8; -.
DR   InParanoid; Q588F8; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Obesity; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..160
FT                   /note="Leptin"
FT                   /id="PRO_0000042930"
FT   DISULFID        109..160
FT                   /evidence="ECO:0000250"
FT   CONFLICT        102
FT                   /note="N -> K (in Ref. 1; BAD94451)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   160 AA;  18260 MW;  CE60FEAF266F3252 CRC64;
     MDYTLALALS LLQLSMCTPV PMMQDSGRMK TKAKWMVQQL LVRLKDNVWP HFDMPPTFSA
     DDLEGSASIV ARLENFNSLI SDNLGDVLQI KAEISSLTGY LNNWRHNNCK EQRPRTAVPG
     LPQEPQRRKD FIQSVTIDAL MSMKEFLNLL LQNLDHLEIC