ID   LERL1_BOVIN             Reviewed;         131 AA.
AC   Q32PD8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Leptin receptor overlapping transcript-like 1;
GN   Name=LEPROTL1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negatively regulates growth hormone (GH) receptor cell
CC       surface expression in liver. May play a role in liver resistance to GH
CC       during periods of reduced nutrient availability (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the OB-RGRP/VPS55 family. {ECO:0000305}.
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DR   EMBL; BT025351; ABF57307.1; -; mRNA.
DR   EMBL; BC108155; AAI08156.1; -; mRNA.
DR   RefSeq; NP_001032539.1; NM_001037462.2.
DR   AlphaFoldDB; Q32PD8; -.
DR   STRING; 9913.ENSBTAP00000045064; -.
DR   PaxDb; Q32PD8; -.
DR   PRIDE; Q32PD8; -.
DR   Ensembl; ENSBTAT00000047911; ENSBTAP00000045064; ENSBTAG00000013581.
DR   GeneID; 513036; -.
DR   KEGG; bta:513036; -.
DR   CTD; 23484; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013581; -.
DR   VGNC; VGNC:30845; LEPROTL1.
DR   eggNOG; KOG2174; Eukaryota.
DR   GeneTree; ENSGT00390000006503; -.
DR   HOGENOM; CLU_134810_2_2_1; -.
DR   InParanoid; Q32PD8; -.
DR   OMA; HSAVITW; -.
DR   OrthoDB; 1642378at2759; -.
DR   TreeFam; TF313689; -.
DR   Proteomes; UP000009136; Chromosome 27.
DR   Bgee; ENSBTAG00000013581; Expressed in diaphragm and 104 other tissues.
DR   ExpressionAtlas; Q32PD8; baseline.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0060400; P:negative regulation of growth hormone receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR007262; Vps55/LEPROT.
DR   PANTHER; PTHR12050; PTHR12050; 1.
DR   Pfam; PF04133; Vps55; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..131
FT                   /note="Leptin receptor overlapping transcript-like 1"
FT                   /id="PRO_0000327389"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   131 AA;  14405 MW;  ED58F768DC5D2299 CRC64;
     MAGIKALISL SFGGAIGLMF LMLGCALPIY NQYWPLFVLF FYILSPIPYC IARRLVDDTD
     AMSNACKELA IFLTTGIVVS AFGLPIVFAR ANLIEWGACA LVLTGNTVIF ATILGFFLVF
     GSNDDFSWQQ W