LERL1_MOUSE
ID LERL1_MOUSE Reviewed; 131 AA.
AC Q9CQ74; Q3U662;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Leptin receptor overlapping transcript-like 1;
DE AltName: Full=Endospanin-2;
GN Name=Leprotl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Cerebellum, and Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND INDUCTION.
RX PubMed=19907080; DOI=10.1172/jci34997;
RA Touvier T., Conte-Auriol F., Briand O., Cudejko C., Paumelle R., Caron S.,
RA Bauge E., Rouille Y., Salles J.P., Staels B., Bailleul B.;
RT "LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action
RT in mice.";
RL J. Clin. Invest. 119:3830-3838(2009).
CC -!- FUNCTION: Negatively regulates growth hormone (GH) receptor cell
CC surface expression in liver. May play a role in liver resistance to GH
CC during periods of reduced nutrient availability.
CC {ECO:0000269|PubMed:19907080}.
CC -!- SUBUNIT: Interacts with RAB13. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Up-regulated in the liver of fasting animals.
CC {ECO:0000269|PubMed:19907080}.
CC -!- SIMILARITY: Belongs to the OB-RGRP/VPS55 family. {ECO:0000305}.
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DR EMBL; AK003329; BAB22717.1; -; mRNA.
DR EMBL; AK013870; BAB29025.1; -; mRNA.
DR EMBL; AK075740; BAC35921.1; -; mRNA.
DR EMBL; AK150289; BAE29444.1; -; mRNA.
DR EMBL; AK153277; BAE31863.1; -; mRNA.
DR EMBL; AK159401; BAE35053.1; -; mRNA.
DR EMBL; BC004677; AAH04677.1; -; mRNA.
DR CCDS; CCDS22239.1; -.
DR RefSeq; NP_080885.1; NM_026609.2.
DR AlphaFoldDB; Q9CQ74; -.
DR BioGRID; 212717; 2.
DR STRING; 10090.ENSMUSP00000033910; -.
DR SwissPalm; Q9CQ74; -.
DR MaxQB; Q9CQ74; -.
DR PaxDb; Q9CQ74; -.
DR PRIDE; Q9CQ74; -.
DR ProteomicsDB; 265061; -.
DR Antibodypedia; 63110; 26 antibodies from 10 providers.
DR DNASU; 68192; -.
DR Ensembl; ENSMUST00000033910; ENSMUSP00000033910; ENSMUSG00000031513.
DR GeneID; 68192; -.
DR KEGG; mmu:68192; -.
DR UCSC; uc009lkp.1; mouse.
DR CTD; 23484; -.
DR MGI; MGI:1915442; Leprotl1.
DR VEuPathDB; HostDB:ENSMUSG00000031513; -.
DR eggNOG; KOG2174; Eukaryota.
DR GeneTree; ENSGT00390000006503; -.
DR HOGENOM; CLU_134810_2_2_1; -.
DR InParanoid; Q9CQ74; -.
DR OMA; HSAVITW; -.
DR OrthoDB; 1642378at2759; -.
DR PhylomeDB; Q9CQ74; -.
DR TreeFam; TF313689; -.
DR BioGRID-ORCS; 68192; 6 hits in 71 CRISPR screens.
DR ChiTaRS; Leprotl1; mouse.
DR PRO; PR:Q9CQ74; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9CQ74; protein.
DR Bgee; ENSMUSG00000031513; Expressed in ventral horn of spinal cord and 243 other tissues.
DR Genevisible; Q9CQ74; MM.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR GO; GO:0060400; P:negative regulation of growth hormone receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR007262; Vps55/LEPROT.
DR PANTHER; PTHR12050; PTHR12050; 1.
DR Pfam; PF04133; Vps55; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..131
FT /note="Leptin receptor overlapping transcript-like 1"
FT /id="PRO_0000215198"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 131 AA; 14414 MW; BB168968DC440A3E CRC64;
MAGIKALISL SFGGAIGLMF LMLGCALPIY NQYWPLFVLF FYILSPIPYC IARRLVDDTD
AMSNACKELA IFLTTGIVVS AFGLPVVFAR AHLIEWGACA LVLTGNTVIF ATILGFFLVF
GSNDDFSWQQ W
