ID   LERL1_PONAB             Reviewed;         131 AA.
AC   Q5RDE9;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Leptin receptor overlapping transcript-like 1;
GN   Name=LEPROTL1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negatively regulates growth hormone (GH) receptor cell
CC       surface expression in liver. May play a role in liver resistance to GH
CC       during periods of reduced nutrient availability (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the OB-RGRP/VPS55 family. {ECO:0000305}.
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DR   EMBL; CR857963; CAH90208.1; -; mRNA.
DR   RefSeq; NP_001125079.1; NM_001131607.1.
DR   AlphaFoldDB; Q5RDE9; -.
DR   STRING; 9601.ENSPPYP00000020720; -.
DR   Ensembl; ENSPPYT00000040774; ENSPPYP00000025896; ENSPPYG00000018484.
DR   GeneID; 100171961; -.
DR   KEGG; pon:100171961; -.
DR   CTD; 23484; -.
DR   eggNOG; KOG2174; Eukaryota.
DR   GeneTree; ENSGT00390000006503; -.
DR   HOGENOM; CLU_134810_2_2_1; -.
DR   InParanoid; Q5RDE9; -.
DR   OMA; HSAVITW; -.
DR   OrthoDB; 1642378at2759; -.
DR   TreeFam; TF313689; -.
DR   Proteomes; UP000001595; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007262; Vps55/LEPROT.
DR   PANTHER; PTHR12050; PTHR12050; 1.
DR   Pfam; PF04133; Vps55; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..131
FT                   /note="Leptin receptor overlapping transcript-like 1"
FT                   /id="PRO_0000215199"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   131 AA;  14428 MW;  E5E75B7C77A99DD7 CRC64;
     MAGIKALISL SFGGAIGLMF LMLGCALPIY NKYWPLFVLF FYILSPIPYC IARRLVDDTD
     AMSNACKELA IFLTTGIVVS AFGLPIVFAR AHLIEWGACA LVLTGNTVIF ATILGFFLVF
     GSNDDFSWQQ W