ID   LET12_SOLLC             Reviewed;         426 AA.
AC   O22300;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Homeobox protein knotted-1-like LET12;
GN   Name=LET12;
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. VFNT Cherry;
RX   PubMed=9484482; DOI=10.1023/a:1005925508579;
RA   Janssen B.-J., Williams A., Chen J.J., Mathern J., Hake S., Sinha N.;
RT   "Isolation and characterization of two knotted-like homeobox genes from
RT   tomato.";
RL   Plant Mol. Biol. 36:417-425(1998).
CC   -!- FUNCTION: May have a role to play in formative events in ovule and
CC       embryo morphogenesis.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed in the mature plant.
CC   -!- SIMILARITY: Belongs to the TALE/KNOX homeobox family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00559}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF000142; AAC49918.1; -; mRNA.
DR   PIR; T04318; T04318.
DR   AlphaFoldDB; O22300; -.
DR   SMR; O22300; -.
DR   STRING; 4081.Solyc07g007120.2.1; -.
DR   PaxDb; O22300; -.
DR   PRIDE; O22300; -.
DR   eggNOG; KOG0773; Eukaryota.
DR   InParanoid; O22300; -.
DR   Proteomes; UP000004994; Unplaced.
DR   ExpressionAtlas; O22300; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR005539; ELK_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR005540; KNOX1.
DR   InterPro; IPR005541; KNOX2.
DR   Pfam; PF03789; ELK; 1.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   Pfam; PF03790; KNOX1; 1.
DR   Pfam; PF03791; KNOX2; 1.
DR   SMART; SM01188; ELK; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM01255; KNOX1; 1.
DR   SMART; SM01256; KNOX2; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS51213; ELK; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..426
FT                   /note="Homeobox protein knotted-1-like LET12"
FT                   /id="PRO_0000048974"
FT   DOMAIN          327..347
FT                   /note="ELK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00559"
FT   DNA_BIND        348..411
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          85..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          270..290
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          406..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..26
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..103
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..153
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   426 AA;  47581 MW;  5B52B9E0A34A86BC CRC64;
     MEFQDHFSQE MVLHQQQQQQ QQQQNAVLRS MLPESPHHDA RKSPPTWLNT SLLRQQHSQF
     GNASSPSSAA AAAAVAGGNN FLHLQTSNSD SSNSNQWLSP TAAAGGGSNG GGSGHNDELS
     ESMNFAKKMS QQHSGGGEEN NNNNNNNNNN NNEEENSWER EKCKADILNH PLYDQLLSAH
     VSCLRIATPV DQLPRIDAQL AQSQNVVAKY SVLGQGQPPL DDKDLDQFMT HYVLLLSSFK
     EQLQQHVRVH AMEAVMACWE LEQSLQSLTG VAPGEGTGAT MSDDDDDQAD SDTNFLDGGF
     DGPDSMGFGP LVPTESERSL MERVRQELKH ELKQGYKEKI VDIREEILRK RRAGKLPGDT
     TSVLKAWWQS HSKWPYPTEE DKARLVQETG LQLKQINNWF INQRKRNWHS NPSTSSSQKS
     QTQECR