ID   LETH1_HELHO             Reviewed;          33 AA.
AC   Q7LZ31;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 2.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Helofensin-1;
DE   AltName: Full=Lethal toxin;
DE   Flags: Fragment;
OS   Heloderma horridum horridum (Mexican beaded lizard).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Anguimorpha; Neoanguimorpha; Helodermatidae; Heloderma.
OX   NCBI_TaxID=8552;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   TOXIC DOSE.
RC   TISSUE=Venom;
RX   PubMed=3401225; DOI=10.1016/0006-291x(88)90183-0;
RA   Komori Y., Nikai T., Sugihara H.;
RT   "Purification and characterization of a lethal toxin from the venom of
RT   Heloderma horridum horridum.";
RL   Biochem. Biophys. Res. Commun. 154:613-619(1988).
CC   -!- FUNCTION: Lethal toxin which possesses an inhibitory effect on direct
CC       electrical stimulation of the isolated hemi-diaphragm. Neither
CC       hemorrhagic nor hemolytic activities are detected. Phospholipase A2
CC       activity, proteolytic activity and arginine esterolytic activity are
CC       absent. {ECO:0000269|PubMed:3401225}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:3401225}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:3401225}.
CC   -!- TOXIC DOSE: LD(50) is 0.135 mg/kg on mice.
CC       {ECO:0000269|PubMed:3401225}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. Helofensin subfamily.
CC       {ECO:0000305}.
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DR   PIR; A28890; A28890.
DR   AlphaFoldDB; Q7LZ31; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Neurotoxin; Secreted; Toxin.
FT   CHAIN           1..>33
FT                   /note="Helofensin-1"
FT                   /id="PRO_0000093669"
FT   UNSURE          7
FT                   /note="Assigned by comparison with orthologs"
FT   UNSURE          11
FT                   /note="Assigned by comparison with orthologs"
FT   UNSURE          14
FT                   /note="Assigned by comparison with orthologs"
FT   UNSURE          19
FT                   /note="Assigned by comparison with orthologs"
FT   UNSURE          29
FT                   /note="Assigned by comparison with orthologs"
FT   NON_TER         33
SQ   SEQUENCE   33 AA;  3729 MW;  2978CBFF5654D551 CRC64;
     AYTTEQCRAL NGTCRFYACF PKNVVIGKCD WLG