ID   LETH2_HELSC             Reviewed;         183 AA.
AC   D2X5W3;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   25-MAY-2022, entry version 19.
DE   RecName: Full=Helofensin-2;
DE   AltName: Full=Lethal toxin 2;
DE   Flags: Precursor;
OS   Heloderma suspectum cinctum (Banded Gila monster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Anguimorpha; Neoanguimorpha; Helodermatidae; Heloderma.
OX   NCBI_TaxID=537493;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=19837656; DOI=10.1093/molbev/msp251;
RA   Fry B.G., Roelants K., Winter K., Hodgson W.C., Griesman L., Kwok H.F.,
RA   Scanlon D., Karas J., Shaw C., Wong L., Norman J.A.;
RT   "Novel venom proteins produced by differential domain-expression strategies
RT   in beaded lizards and gila monsters (genus Heloderma).";
RL   Mol. Biol. Evol. 27:395-407(2010).
CC   -!- FUNCTION: Lethal toxin which possesses an inhibitory effect on direct
CC       electrical stimulation of the isolated hemi-diaphragm of mice. Neither
CC       hemorrhagic nor hemolytic activities are detected. Phospholipase A2
CC       activity, proteolytic activity and arginine esterolytic activity are
CC       absent (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the mandibular venom gland.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. Helofensin subfamily.
CC       {ECO:0000305}.
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DR   EMBL; GQ918270; ADB08411.1; -; mRNA.
DR   AlphaFoldDB; D2X5W3; -.
DR   SMR; D2X5W3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   2: Evidence at transcript level;
KW   Repeat; Secreted; Signal; Toxin.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   CHAIN           27..183
FT                   /note="Helofensin-2"
FT                   /id="PRO_0000414107"
FT   REPEAT          27..64
FT                   /note="C(6)C(4)C(9)C(6)CC 1; approximate"
FT   REPEAT          65..101
FT                   /note="C(6)C(4)C(9)C(6)CC 2; approximate"
FT   REPEAT          102..139
FT                   /note="C(6)C(4)C(9)C(6)CC 3; approximate"
FT   REPEAT          140..177
FT                   /note="C(6)C(4)C(9)C(6)CC 4; approximate"
SQ   SEQUENCE   183 AA;  19675 MW;  5CD856C524826D66 CRC64;
     MQMDWLFIAV ISGIGLLSSG VPGTQGAYTT EQCRALNGSC NFYACFPKNV IIGKCDWWGW
     SCCARTPLER CTAKKGTCTK TGCTKTDTDH GPCDGGAQCC QRDPVKYCKF HGNVCGRGKC
     PMDHIPIGEQ CMPGYPCCKR DGPAYCKSKG GKCLRRCSQI VPTDIIGVCA DGVPCCKSRQ
     STG