LETH3_HELSC
ID LETH3_HELSC Reviewed; 182 AA.
AC D2X5W4;
DT 14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT 02-MAR-2010, sequence version 1.
DT 25-MAY-2022, entry version 21.
DE RecName: Full=Helofensin-3;
DE AltName: Full=Lethal toxin 3;
DE Flags: Precursor;
OS Heloderma suspectum cinctum (Banded Gila monster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Anguimorpha; Neoanguimorpha; Helodermatidae; Heloderma.
OX NCBI_TaxID=537493;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=19837656; DOI=10.1093/molbev/msp251;
RA Fry B.G., Roelants K., Winter K., Hodgson W.C., Griesman L., Kwok H.F.,
RA Scanlon D., Karas J., Shaw C., Wong L., Norman J.A.;
RT "Novel venom proteins produced by differential domain-expression strategies
RT in beaded lizards and gila monsters (genus Heloderma).";
RL Mol. Biol. Evol. 27:395-407(2010).
CC -!- FUNCTION: Lethal toxin which possesses an inhibitory effect on direct
CC electrical stimulation of the isolated hemi-diaphragm of mice. Neither
CC hemorrhagic nor hemolytic activities are detected. Phospholipase A2
CC activity, proteolytic activity and arginine esterolytic activity are
CC absent (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the mandibular venom gland.
CC -!- SIMILARITY: Belongs to the beta-defensin family. Helofensin subfamily.
CC {ECO:0000305}.
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DR EMBL; GQ918271; ADB08412.1; -; mRNA.
DR AlphaFoldDB; D2X5W4; -.
DR TCDB; 1.C.85.4.2; the pore-forming Beta-defensin (Beta-defensin) family.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR InterPro; IPR001855; Defensin_beta-typ.
DR Pfam; PF00711; Defensin_beta; 1.
PE 2: Evidence at transcript level;
KW Repeat; Secreted; Signal; Toxin.
FT SIGNAL 1..26
FT /evidence="ECO:0000250"
FT CHAIN 27..182
FT /note="Helofensin-3"
FT /id="PRO_0000414108"
FT REPEAT 27..64
FT /note="C(6)C(4)C(9)C(6)CC 1; approximate"
FT REPEAT 65..101
FT /note="C(6)C(4)C(9)C(6)CC 2; approximate"
FT REPEAT 102..138
FT /note="C(6)C(4)C(9)C(6)CC 3; approximate"
FT REPEAT 139..176
FT /note="C(6)C(4)C(9)C(6)CC 4; approximate"
SQ SEQUENCE 182 AA; 19456 MW; AF1E6D3FC6BB7AA9 CRC64;
MQMDWLFIAV ISGIGLLSSG VPGTQGAYTT EQCRALNGSC NFYACFPKNV IIGKCDWWGW
SCCARTPLER CTAKKGTCTK TGCTKTDTDH GPCDGGAQCC QRDPVKYCKF HGNVCGRGKC
PMDHIPIGEC TPGYPCCKRD GPAYCKSKGG KCLNRCPQIV PTNVIGVCAT GVPCCKSRQS
TG