LETM1_CHICK
ID LETM1_CHICK Reviewed; 752 AA.
AC Q5ZK33;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Mitochondrial proton/calcium exchanger protein {ECO:0000305};
DE AltName: Full=Leucine zipper-EF-hand-containing transmembrane protein 1;
DE Flags: Precursor;
GN Name=LETM1; ORFNames=RCJMB04_13i11;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Mitochondrial proton/calcium antiporter that mediates proton-
CC dependent calcium efflux from mitochondrion (By similarity). Required
CC for the maintenance of the tubular shape and cristae organization (By
CC similarity). {ECO:0000250|UniProtKB:O95202,
CC ECO:0000250|UniProtKB:Q9Z2I0}.
CC -!- SUBUNIT: Homohexamer. {ECO:0000250|UniProtKB:Q9Z2I0}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9Z2I0}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9Z2I0}.
CC -!- SIMILARITY: Belongs to the LETM1 family. {ECO:0000305}.
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DR EMBL; AJ720251; CAG31910.1; -; mRNA.
DR RefSeq; NP_001006461.2; NM_001006461.2.
DR AlphaFoldDB; Q5ZK33; -.
DR SMR; Q5ZK33; -.
DR STRING; 9031.ENSGALP00000043101; -.
DR PaxDb; Q5ZK33; -.
DR PRIDE; Q5ZK33; -.
DR GeneID; 422898; -.
DR KEGG; gga:422898; -.
DR CTD; 3954; -.
DR VEuPathDB; HostDB:geneid_422898; -.
DR eggNOG; KOG1043; Eukaryota.
DR HOGENOM; CLU_008958_2_1_1; -.
DR InParanoid; Q5ZK33; -.
DR OrthoDB; 516860at2759; -.
DR PhylomeDB; Q5ZK33; -.
DR TreeFam; TF316321; -.
DR PRO; PR:Q5ZK33; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0015369; F:calcium:proton antiporter activity; ISS:UniProtKB.
DR GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR GO; GO:0099093; P:calcium export from the mitochondrion; ISS:UniProtKB.
DR GO; GO:0006875; P:cellular metal ion homeostasis; IBA:GO_Central.
DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; ISS:UniProtKB.
DR GO; GO:0006851; P:mitochondrial calcium ion transmembrane transport; ISS:UniProtKB.
DR GO; GO:0034214; P:protein hexamerization; ISS:UniProtKB.
DR GO; GO:0051260; P:protein homooligomerization; ISS:UniProtKB.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR011685; LETM1-like.
DR InterPro; IPR044202; LETM1/MDM38-like.
DR InterPro; IPR033122; LETM1_RBD.
DR PANTHER; PTHR14009; PTHR14009; 1.
DR Pfam; PF07766; LETM1; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS51758; LETM1_RBD; 1.
PE 2: Evidence at transcript level;
KW Antiport; Calcium; Calcium transport; Coiled coil; Ion transport; Membrane;
KW Metal-binding; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transit peptide; Transmembrane; Transmembrane helix;
KW Transport.
FT TRANSIT 1..112
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 113..752
FT /note="Mitochondrial proton/calcium exchanger protein"
FT /id="PRO_0000380702"
FT TOPO_DOM 113..205
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..752
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT DOMAIN 249..518
FT /note="Letm1 RBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01094"
FT DOMAIN 676..711
FT /note="EF-hand"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT COILED 443..509
FT /evidence="ECO:0000255"
FT COILED 550..639
FT /evidence="ECO:0000255"
FT COILED 720..752
FT /evidence="ECO:0000255"
SQ SEQUENCE 752 AA; 85849 MW; 5A512AB408E44246 CRC64;
MLLQSCGRRA CRLPRALRRQ APLGNLGDRA CLSCTSLRLA NKMTVHFKYC TSVAPVYAYS
KKDHYCCWTK GLERTYFTLM SSSGSWTPLA AMGVLGPKYL PVRWWHSSRS LQDDSIVEKS
LKSLKDKNKK LEEGGPVYSP TEVEVVKKSI GQRIVDELKH YYHGFRLLWI DTKIAARMLW
RILHGNTLSR RERRQFLRIC ADLFRLVPFL VFLVVPFMEF LLPVALKLFP NMLPSTFETK
SKKEERLKKQ LRVKLELAKF LQDTIEEMAL KNKAAKGNVT KDFSTFFQKI RETGERPSNE
EILRFSKLFE DELTLDNLTR PQLVALCKLL ELQSIGTNNF LRFQLTMRLR TIKADDKMIA
EEGVDSLTVK ELQAACRARG MRALGVTEER LREQLKQWLD LHLNQEIPTS LLILSRAMYL
PDTLSPADQL KTTLQTLPES VAKEAQVKVA EVEGEKVDNK ARLEATLQEE AAIRKENEEK
EMERITEAAE KAKETLQVAA MKLESAVDLE PAVLQVKESQ VAMDSKQELA KADMETLKDT
APVLEGIKGE EITKEEIDML SDACNKLQEQ KKSLTKEKEE LEELKGDIQE YNEDLQEIKE
LSKAGQEEVV EESKASKRLT KRVNRMIGQI DKIINELETN QKTVDVKLDR GDSPPAGENL
ISIAELINAM KQIQKIPEEK LTRIAEALDE NKDGKIDIDN VVKVVELIDK EDVDIGTSQV
AEIMALLQKE EKLEEKEKAK EKQDKEAAEV KN
