LETM1_XENTR
ID LETM1_XENTR Reviewed; 760 AA.
AC Q0VA06;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Mitochondrial proton/calcium exchanger protein {ECO:0000305};
DE AltName: Full=Leucine zipper-EF-hand-containing transmembrane protein 1;
DE Flags: Precursor;
GN Name=letm1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial proton/calcium antiporter that mediates proton-
CC dependent calcium efflux from mitochondrion (By similarity). Required
CC for the maintenance of the tubular shape and cristae organization (By
CC similarity). {ECO:0000250|UniProtKB:O95202,
CC ECO:0000250|UniProtKB:Q9Z2I0}.
CC -!- SUBUNIT: Homohexamer. {ECO:0000250|UniProtKB:Q9Z2I0}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9Z2I0}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9Z2I0}.
CC -!- SIMILARITY: Belongs to the LETM1 family. {ECO:0000305}.
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DR EMBL; BC121318; AAI21319.1; -; mRNA.
DR RefSeq; NP_001072793.1; NM_001079325.1.
DR AlphaFoldDB; Q0VA06; -.
DR SMR; Q0VA06; -.
DR STRING; 8364.ENSXETP00000013503; -.
DR PaxDb; Q0VA06; -.
DR GeneID; 780254; -.
DR KEGG; xtr:780254; -.
DR CTD; 3954; -.
DR Xenbase; XB-GENE-954420; letm1.
DR eggNOG; KOG1043; Eukaryota.
DR HOGENOM; CLU_686163_0_0_1; -.
DR InParanoid; Q0VA06; -.
DR OrthoDB; 516860at2759; -.
DR Proteomes; UP000008143; Chromosome 1.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000032769; Expressed in testis and 12 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0015369; F:calcium:proton antiporter activity; ISS:UniProtKB.
DR GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR GO; GO:0099093; P:calcium export from the mitochondrion; ISS:UniProtKB.
DR GO; GO:0006875; P:cellular metal ion homeostasis; IBA:GO_Central.
DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; ISS:UniProtKB.
DR GO; GO:0006851; P:mitochondrial calcium ion transmembrane transport; ISS:UniProtKB.
DR GO; GO:0034214; P:protein hexamerization; ISS:UniProtKB.
DR GO; GO:0051260; P:protein homooligomerization; ISS:UniProtKB.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR011685; LETM1-like.
DR InterPro; IPR044202; LETM1/MDM38-like.
DR InterPro; IPR033122; LETM1_RBD.
DR PANTHER; PTHR14009; PTHR14009; 1.
DR Pfam; PF07766; LETM1; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS51758; LETM1_RBD; 1.
PE 2: Evidence at transcript level;
KW Antiport; Calcium; Calcium transport; Coiled coil; Ion transport; Membrane;
KW Metal-binding; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transit peptide; Transmembrane; Transmembrane helix;
KW Transport.
FT TRANSIT 1..117
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 118..760
FT /note="Mitochondrial proton/calcium exchanger protein"
FT /id="PRO_0000380704"
FT TOPO_DOM 118..210
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..760
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT DOMAIN 254..555
FT /note="Letm1 RBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01094"
FT DOMAIN 683..718
FT /note="EF-hand"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT COILED 463..505
FT /evidence="ECO:0000255"
FT COILED 557..657
FT /evidence="ECO:0000255"
FT COILED 723..760
FT /evidence="ECO:0000255"
FT BINDING 696
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 698
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 700
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 702
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 707
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 760 AA; 86049 MW; EBFDE5A6DA52AE59 CRC64;
MAALLVRGCA LRPSWATRSA PICARGEGMK GNFAESVCLG CTSLRLLNYR NACFRSCTAA
RPVYVASRKG DNEFLWTDIS ERRYYKYLSS PASWTALKMG PWDLSVRNLH LSRPLFDDSV
VEKSLKSLKD KNKKLEEGGP VYSPVSEVET VKKSLGQKVI DEIKHYYHGF RLLWIDTKIA
ARMLRQILNG HAMSRRERRQ FLRICADLFR LVPFLVFVIV PFMEFLLPVA LKLFPNMLPS
TFETFSKKEE RLKKELRVKL ELAKFLQDTI EEIALRNKAA KGDVTAEFAT FFQKIRSTGE
RPSNEEIVRF SKLFEDELTL DNLTRPQLVA LCKLLELQSI GTNNFLRFQL TMKLRSIKAD
DKLIADEGLD SLTVTELQAA CRARGMRALG VTEDRLKEQL KQWLELHLDQ EIPTSLLLLS
RALYLPDTLS PADQLKTTLQ TLPESVAKEA QVKVAAVECE KVDNKTKLEA TLQEEEAIRK
ENQEKEMERL ADAAKESQQV AAKVDVQSAP EEAISGEMKT ATADTAAEPA VAQMSASEQA
EILKDTAPVL EGIKGEEITK EEIDILSDAC TKLKEQKKLL TKEKEELSEL KDDVQEYSED
LQEIKKELSK TGQEKVLQET KASKILTKRV NRMIGQMDKI ISELENEEKV LDEHIEKGSV
PPVGENLVSI NELISIMRHI QKIPEQKLQR IAAALDENKD GKIDLDDVAK VVELIDKEDI
DISTSQVAEI MELLQKEEKL AEKEKAKEKV EKEQAAEAQN
