LETM2_HUMAN
ID LETM2_HUMAN Reviewed; 491 AA.
AC Q2VYF4; A6NMG3; Q8NCR2; Q96LL1;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=LETM1 domain-containing protein LETM2, mitochondrial;
DE AltName: Full=LETM1 and EF-hand domain-containing protein 2;
DE AltName: Full=Leucine zipper-EF-hand-containing transmembrane protein 1-like;
DE Flags: Precursor;
GN Name=LETM2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Xu J., Xie Y., Mao Y.;
RT "Characterization of a novel gene similar to leucine zipper-EF-hand
RT containing transmembrane protein 1 (LETM1).";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q2VYF4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2VYF4-2; Sequence=VSP_028589;
CC Name=3;
CC IsoId=Q2VYF4-3; Sequence=VSP_028589, VSP_028590;
CC Name=4;
CC IsoId=Q2VYF4-4; Sequence=VSP_028588, VSP_028591;
CC -!- CAUTION: Despite its name, it does not contain any EF-hand domains.
CC {ECO:0000305}.
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DR EMBL; AY173945; AAO49715.1; -; mRNA.
DR EMBL; AK058138; BAB71680.1; -; mRNA.
DR EMBL; AC087623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC029541; AAH29541.2; -; mRNA.
DR CCDS; CCDS56534.1; -. [Q2VYF4-2]
DR CCDS; CCDS6106.1; -. [Q2VYF4-3]
DR CCDS; CCDS69466.1; -. [Q2VYF4-1]
DR RefSeq; NP_001186588.1; NM_001199659.2. [Q2VYF4-2]
DR RefSeq; NP_001273748.1; NM_001286819.1. [Q2VYF4-1]
DR RefSeq; NP_653253.1; NM_144652.3. [Q2VYF4-3]
DR RefSeq; XP_011542708.1; XM_011544406.1. [Q2VYF4-2]
DR RefSeq; XP_011542709.1; XM_011544407.1. [Q2VYF4-2]
DR RefSeq; XP_011542712.1; XM_011544410.2. [Q2VYF4-4]
DR RefSeq; XP_016868540.1; XM_017013051.1. [Q2VYF4-1]
DR RefSeq; XP_016868541.1; XM_017013052.1. [Q2VYF4-1]
DR RefSeq; XP_016868542.1; XM_017013053.1. [Q2VYF4-1]
DR RefSeq; XP_016868543.1; XM_017013054.1. [Q2VYF4-1]
DR RefSeq; XP_016868544.1; XM_017013055.1. [Q2VYF4-1]
DR RefSeq; XP_016868545.1; XM_017013056.1. [Q2VYF4-1]
DR AlphaFoldDB; Q2VYF4; -.
DR SMR; Q2VYF4; -.
DR BioGRID; 126495; 22.
DR IntAct; Q2VYF4; 1.
DR STRING; 9606.ENSP00000369291; -.
DR GlyGen; Q2VYF4; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q2VYF4; -.
DR PhosphoSitePlus; Q2VYF4; -.
DR BioMuta; LETM2; -.
DR DMDM; 160013759; -.
DR jPOST; Q2VYF4; -.
DR MassIVE; Q2VYF4; -.
DR MaxQB; Q2VYF4; -.
DR PaxDb; Q2VYF4; -.
DR PeptideAtlas; Q2VYF4; -.
DR PRIDE; Q2VYF4; -.
DR ProteomicsDB; 61530; -. [Q2VYF4-1]
DR ProteomicsDB; 61531; -. [Q2VYF4-2]
DR ProteomicsDB; 61532; -. [Q2VYF4-3]
DR ProteomicsDB; 61533; -. [Q2VYF4-4]
DR Antibodypedia; 11001; 111 antibodies from 22 providers.
DR DNASU; 137994; -.
DR Ensembl; ENST00000297720.9; ENSP00000297720.5; ENSG00000165046.13. [Q2VYF4-3]
DR Ensembl; ENST00000379957.9; ENSP00000369291.4; ENSG00000165046.13. [Q2VYF4-1]
DR Ensembl; ENST00000523983.6; ENSP00000428765.2; ENSG00000165046.13. [Q2VYF4-2]
DR Ensembl; ENST00000527710.5; ENSP00000434867.1; ENSG00000165046.13. [Q2VYF4-4]
DR GeneID; 137994; -.
DR KEGG; hsa:137994; -.
DR MANE-Select; ENST00000379957.9; ENSP00000369291.4; NM_001286819.2; NP_001273748.1.
DR UCSC; uc003xll.4; human. [Q2VYF4-1]
DR CTD; 137994; -.
DR DisGeNET; 137994; -.
DR GeneCards; LETM2; -.
DR HGNC; HGNC:14648; LETM2.
DR HPA; ENSG00000165046; Tissue enriched (testis).
DR neXtProt; NX_Q2VYF4; -.
DR OpenTargets; ENSG00000165046; -.
DR PharmGKB; PA134887111; -.
DR VEuPathDB; HostDB:ENSG00000165046; -.
DR eggNOG; KOG1043; Eukaryota.
DR GeneTree; ENSGT00950000183167; -.
DR HOGENOM; CLU_008958_0_0_1; -.
DR InParanoid; Q2VYF4; -.
DR OMA; GRKNEEF; -.
DR OrthoDB; 516860at2759; -.
DR PhylomeDB; Q2VYF4; -.
DR TreeFam; TF316321; -.
DR PathwayCommons; Q2VYF4; -.
DR SignaLink; Q2VYF4; -.
DR BioGRID-ORCS; 137994; 17 hits in 1074 CRISPR screens.
DR ChiTaRS; LETM2; human.
DR GenomeRNAi; 137994; -.
DR Pharos; Q2VYF4; Tdark.
DR PRO; PR:Q2VYF4; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q2VYF4; protein.
DR Bgee; ENSG00000165046; Expressed in left testis and 108 other tissues.
DR ExpressionAtlas; Q2VYF4; baseline and differential.
DR Genevisible; Q2VYF4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR GO; GO:0006875; P:cellular metal ion homeostasis; IBA:GO_Central.
DR InterPro; IPR011685; LETM1-like.
DR InterPro; IPR044202; LETM1/MDM38-like.
DR InterPro; IPR033122; LETM1_RBD.
DR InterPro; IPR045742; LETM2_N.
DR PANTHER; PTHR14009; PTHR14009; 1.
DR Pfam; PF07766; LETM1; 1.
DR Pfam; PF19324; LETM2_N; 1.
DR PROSITE; PS51758; LETM1_RBD; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix.
FT TRANSIT 1..25
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 26..491
FT /note="LETM1 domain-containing protein LETM2,
FT mitochondrial"
FT /id="PRO_0000307137"
FT TOPO_DOM 26..177
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..491
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT DOMAIN 221..438
FT /note="Letm1 RBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01094"
FT REGION 94..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 435..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 208..235
FT /evidence="ECO:0000255"
FT COMPBIAS 96..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..214
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028588"
FT VAR_SEQ 1..47
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.1"
FT /id="VSP_028589"
FT VAR_SEQ 168..215
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_028590"
FT VAR_SEQ 215
FT /note="K -> M (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028591"
FT CONFLICT 448
FT /note="T -> A (in Ref. 1; AAO49715)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 491 AA; 55921 MW; F7515E57C73237D1 CRC64;
MAFYSYNSVL AIARTRFPSH FVHPTCSSYS PSCAFLHLPD SHLNKTCMKN YESKKYSDPS
QPGNTVLHPG TRLIQKLHTS TCWLQEVPGK PQLEQATKHP QVTSPQATKE TGMEIKEGKQ
SYRQKIMDEL KYYYNGFYLL WIDAKVAARM VWRLLHGQVL TRRERRRLLR TCVDFFRLVP
FMVFLIVPFM EFLLPVFLKL FPEMLPSTFE SESKKEEKQK KKMAVKLELA KFLQETMTEM
ARRNRAKMGD ASTQLSSYVK QVQTGHKPST KEIVRFSKLF EDQLALEHLD RPQLVALCKL
LELQTFGTNN LLRFQLLMKL KSIKADDEII AKEGVTALSV SELQAACRAR GMRSLGLTEE
QLRQQLTEWQ DLHLKENVPP SLLLLSRTFY LIDVKPKPIE IPLSGEAPKT DILVELPTFT
ESKENMVDLA PQLKGTKDED FIQPPPVTSS PITPSTPISL PKGPITSSEE PTLQAKSQMT
AQNSKASSKG A
