ID   LETM2_MOUSE             Reviewed;         480 AA.
AC   Q7TNU7;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=LETM1 domain-containing protein LETM2, mitochondrial;
DE   AltName: Full=LETM1 and EF-hand domain-containing protein 2;
DE   AltName: Full=Leucine zipper-EF-hand-containing transmembrane protein 1-like;
DE   Flags: Precursor;
GN   Name=Letm2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- CAUTION: Despite its name, it does not contain any EF-hand domains.
CC       {ECO:0000305}.
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DR   EMBL; BC055685; AAH55685.1; -; mRNA.
DR   CCDS; CCDS52527.1; -.
DR   RefSeq; NP_766600.2; NM_173012.3.
DR   RefSeq; XP_006509190.1; XM_006509127.2.
DR   RefSeq; XP_017168331.1; XM_017312842.1.
DR   AlphaFoldDB; Q7TNU7; -.
DR   SMR; Q7TNU7; -.
DR   STRING; 10090.ENSMUSP00000078160; -.
DR   PhosphoSitePlus; Q7TNU7; -.
DR   jPOST; Q7TNU7; -.
DR   PaxDb; Q7TNU7; -.
DR   PeptideAtlas; Q7TNU7; -.
DR   PRIDE; Q7TNU7; -.
DR   ProteomicsDB; 290021; -.
DR   Antibodypedia; 11001; 111 antibodies from 22 providers.
DR   DNASU; 270035; -.
DR   Ensembl; ENSMUST00000079160; ENSMUSP00000078160; ENSMUSG00000037363.
DR   GeneID; 270035; -.
DR   KEGG; mmu:270035; -.
DR   UCSC; uc009lgf.2; mouse.
DR   CTD; 137994; -.
DR   MGI; MGI:2444979; Letm2.
DR   VEuPathDB; HostDB:ENSMUSG00000037363; -.
DR   eggNOG; KOG1043; Eukaryota.
DR   GeneTree; ENSGT00950000183167; -.
DR   HOGENOM; CLU_008958_0_0_1; -.
DR   InParanoid; Q7TNU7; -.
DR   OMA; GRKNEEF; -.
DR   OrthoDB; 516860at2759; -.
DR   PhylomeDB; Q7TNU7; -.
DR   TreeFam; TF316321; -.
DR   BioGRID-ORCS; 270035; 2 hits in 73 CRISPR screens.
DR   ChiTaRS; Letm2; mouse.
DR   PRO; PR:Q7TNU7; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q7TNU7; protein.
DR   Bgee; ENSMUSG00000037363; Expressed in spermatid and 199 other tissues.
DR   ExpressionAtlas; Q7TNU7; baseline and differential.
DR   Genevisible; Q7TNU7; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0006875; P:cellular metal ion homeostasis; IBA:GO_Central.
DR   InterPro; IPR011685; LETM1-like.
DR   InterPro; IPR044202; LETM1/MDM38-like.
DR   InterPro; IPR033122; LETM1_RBD.
DR   InterPro; IPR045742; LETM2_N.
DR   PANTHER; PTHR14009; PTHR14009; 1.
DR   Pfam; PF07766; LETM1; 1.
DR   Pfam; PF19324; LETM2_N; 1.
DR   PROSITE; PS51758; LETM1_RBD; 1.
PE   1: Evidence at protein level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..25
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..480
FT                   /note="LETM1 domain-containing protein LETM2,
FT                   mitochondrial"
FT                   /id="PRO_0000307138"
FT   TOPO_DOM        26..175
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        197..480
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          219..436
FT                   /note="Letm1 RBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01094"
FT   REGION          88..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          398..444
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        399..422
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   480 AA;  54458 MW;  6C209AD91AA24657 CRC64;
     MAFYSYNSFL AIFWTRLPGH SVYPSCSHFP SLAFLHLPDS HLRTAYIKNC GSRKYSYPSL
     TGNNKVHPLR TRLPQKLHTT CWLQHVPGKP QLEQTGKPKA ASPQPTKEAK TETTEEKRSL
     RQKIVNELKY YYKGFSLLWI DTKVAARIVW RLLHGNALTR RERRRLLRTC ADVFRLVPFM
     VFIIVPFMEF LIPVFLKLFP DMLPSTFESE SKKEEKQKKT MAAKLEIAKF LQETMTEMAR
     RNRAKLGDAS SQLSSYVKQV QTGHKPSTKE IVRFSKLFKD QLALEHLDRP QLVALCKLLE
     LQTFGTNNLL RFQLLMTLKS IKADDEIIAK EGVKALSVSE LQSACRARGM RSLGLTEEQL
     CQQLTGWLDL HLKENVPPSL LLLSRTFYLI DVKPKPIELP PNIETPKPNL GIPTPPPPES
     KENLTDSAPQ LKGTKDEEFI QLPPVPSSLI APAATISKEA ILQAKSQETS QNSKADSKGA