ID   LETM2_RAT               Reviewed;         459 AA.
AC   Q5PQQ5; A7VL16;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=LETM1 domain-containing protein LETM2, mitochondrial;
DE   AltName: Full=LETM1 and EF-hand domain-containing protein 2;
DE   AltName: Full=Leucine zipper-EF-hand-containing transmembrane protein 1-like;
DE   Flags: Precursor;
GN   Name=Letm2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION,
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=18628306; DOI=10.1242/jcs.026625;
RA   Tamai S., Iida H., Yokota S., Sayano T., Kiguchiya S., Ishihara N.,
RA   Hayashi J., Mihara K., Oka T.;
RT   "Characterization of the mitochondrial protein LETM1, which maintains the
RT   mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L.";
RL   J. Cell Sci. 121:2588-2600(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000269|PubMed:18628306}; Single-pass membrane protein
CC       {ECO:0000269|PubMed:18628306}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5PQQ5-1; Sequence=Displayed;
CC       Name=2; Synonyms=LETM2S;
CC         IsoId=Q5PQQ5-2; Sequence=VSP_037817;
CC   -!- TISSUE SPECIFICITY: Testis and sperm. {ECO:0000269|PubMed:18628306}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the developmental stages from
CC       spermatocyte to spermatozoon. {ECO:0000269|PubMed:18628306}.
CC   -!- CAUTION: Despite its name, it does not contain any EF-hand domains.
CC       {ECO:0000305}.
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DR   EMBL; AB296367; BAF79864.1; -; Genomic_DNA.
DR   EMBL; AB296368; BAF79865.1; -; Genomic_DNA.
DR   EMBL; BC087079; AAH87079.1; -; mRNA.
DR   RefSeq; NP_001012158.1; NM_001012158.1. [Q5PQQ5-1]
DR   AlphaFoldDB; Q5PQQ5; -.
DR   SMR; Q5PQQ5; -.
DR   STRING; 10116.ENSRNOP00000062009; -.
DR   PaxDb; Q5PQQ5; -.
DR   Ensembl; ENSRNOT00000030489; ENSRNOP00000032494; ENSRNOG00000026180. [Q5PQQ5-2]
DR   GeneID; 361169; -.
DR   KEGG; rno:361169; -.
DR   UCSC; RGD:1311220; rat. [Q5PQQ5-1]
DR   CTD; 137994; -.
DR   RGD; 1311220; Letm2.
DR   eggNOG; KOG1043; Eukaryota.
DR   GeneTree; ENSGT00950000183167; -.
DR   InParanoid; Q5PQQ5; -.
DR   OrthoDB; 516860at2759; -.
DR   PhylomeDB; Q5PQQ5; -.
DR   PRO; PR:Q5PQQ5; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0006875; P:cellular metal ion homeostasis; IBA:GO_Central.
DR   InterPro; IPR011685; LETM1-like.
DR   InterPro; IPR044202; LETM1/MDM38-like.
DR   InterPro; IPR033122; LETM1_RBD.
DR   InterPro; IPR045742; LETM2_N.
DR   PANTHER; PTHR14009; PTHR14009; 1.
DR   Pfam; PF07766; LETM1; 1.
DR   Pfam; PF19324; LETM2_N; 1.
DR   PROSITE; PS51758; LETM1_RBD; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transit peptide;
KW   Transmembrane; Transmembrane helix.
FT   TRANSIT         1..25
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..459
FT                   /note="LETM1 domain-containing protein LETM2,
FT                   mitochondrial"
FT                   /id="PRO_0000307139"
FT   TOPO_DOM        26..176
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        198..459
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          220..440
FT                   /note="Letm1 RBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01094"
FT   REGION          88..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          403..459
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        435..459
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         167..214
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_037817"
SQ   SEQUENCE   459 AA;  52524 MW;  065886C1EAF9707A CRC64;
     MAFYSYNSFL AIFWTRLPGH SVHPPCSHFP PLAFFHLPDS HLRTAYMKNC GSRKYSYPGL
     TGNNKVHPLR TRLPQKLHTT CWLQNHPGKP QPEQIPEEPK ATDPQPTKDD QTEVAEGKWS
     LRQKIIDEVK YYYNGFSLLW IDTKVAARIV WRLLHGQVLT RRERRRLLRT CADVFRLVPF
     VVFIIVPFME FLIPVFLKLF PDMLPSTFES ESKKEEKQKK MMGAKLEIAK FLQETMTEMA
     KRNRAKLDDD SSDSSQLSSY VKQVQTGHKP STKEIVRFSK LFEDQLALEH LRRPQLVALC
     KLLELQAFGT NNLLRFQLLM TLRSIKADDE VIAKEGVKAL SVSELQAACR ARGMRSLGLT
     EEQLRQQLTE WLDLHLKENV PPSLLLLSRT FYLIDVKPKP IELPPSIETP KTNLGIPSSP
     PPESKEDITD PAPQLNGTKI LQAKSQETSQ NSKANSKGA