ID   LETM2_XENTR             Reviewed;         444 AA.
AC   Q28DA8;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=LETM1 domain-containing protein LETM2, mitochondrial;
DE   AltName: Full=LETM1 and EF-hand domain-containing protein 2;
DE   AltName: Full=Leucine zipper-EF-hand-containing transmembrane protein 1-like;
DE   Flags: Precursor;
GN   Name=letm2; ORFNames=TEgg018g03.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- CAUTION: Despite its name, it does not contain any EF-hand domains.
CC       {ECO:0000305}.
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DR   EMBL; CR855606; CAJ81832.1; -; mRNA.
DR   RefSeq; NP_001016801.1; NM_001016801.2.
DR   AlphaFoldDB; Q28DA8; -.
DR   SMR; Q28DA8; -.
DR   STRING; 8364.ENSXETP00000005101; -.
DR   PaxDb; Q28DA8; -.
DR   GeneID; 549555; -.
DR   KEGG; xtr:549555; -.
DR   CTD; 137994; -.
DR   Xenbase; XB-GENE-5733328; letm2.
DR   eggNOG; KOG1043; Eukaryota.
DR   InParanoid; Q28DA8; -.
DR   OrthoDB; 516860at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0006875; P:cellular metal ion homeostasis; IBA:GO_Central.
DR   InterPro; IPR011685; LETM1-like.
DR   InterPro; IPR044202; LETM1/MDM38-like.
DR   InterPro; IPR033122; LETM1_RBD.
DR   PANTHER; PTHR14009; PTHR14009; 1.
DR   Pfam; PF07766; LETM1; 1.
DR   PROSITE; PS51758; LETM1_RBD; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..24
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..444
FT                   /note="LETM1 domain-containing protein LETM2,
FT                   mitochondrial"
FT                   /id="PRO_0000307140"
FT   TOPO_DOM        25..155
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        177..444
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          199..417
FT                   /note="Letm1 RBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01094"
FT   REGION          73..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..91
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   444 AA;  49932 MW;  6FE7859A0489202F CRC64;
     MATYTCSVVL ASLRCRSSHL VLRKNLCPIY TSVSCAQNRA YAPRSSCLVQ AAFVSPSWSS
     RAFHTSGFCL QDAPPSPPPP STPPSPPEPE KAPQVVRKSL GQRVVDEIKH FYHGFRLLGI
     DTKVAARMVW RLLHGQVLTR RERRRLMRTC ADLFRLVPFM VFVIVPFMEF LLPVFLKLFP
     EMLPSTFETE SKKEEKVKKK LAAKLEMAKF LQETISEMAR RNKAETGADT QQQFSSYVQQ
     VRGTGEQPST KEIVRFSKLF EDELTLEHLE RSQLVALCRL LELPPIGTNN LLRFQLMMQL
     RSIRADDEMI SKEGVENLTV AELQAASRAR GMRSLGLTEE QLKEQMKQWL DLHLKENVPP
     SLLLLSRALY LTELKPKPIL PLKQAVEIPK INPAVVEAVE AKDNLADTAP TLKGLKGEEL
     VSGTLLKESA VQSKENTKAS ANGV