LEU1_HUMAN
ID LEU1_HUMAN Reviewed; 78 AA.
AC O43261; Q547G6; Q8TE10; Q96QY5;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 12-FEB-2003, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Leukemia-associated protein 1;
DE AltName: Full=Deleted in lymphocytic leukemia 1;
DE AltName: Full=HBV X-transactivated gene 6 protein;
DE AltName: Full=HBV XAg-transactivated protein 6;
GN Name=DLEU1; Synonyms=LEU1, XTP6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=9395242; DOI=10.1038/sj.onc.1201643;
RA Liu Y., Corcoran M., Rasool O., Ivanova G., Ibbotson R., Grander D.,
RA Iyengar A., Baranova A., Kashuba V., Merup M., Wu X., Gardiner A.,
RA Mullenbach R., Poltaraus A., Hulstrom A.L., Juliusson G., Chapman R.,
RA Tiller M., Cotter F., Gahrton G., Yankovsky N., Zabarovsky E., Einhorn S.,
RA Oscier D.;
RT "Cloning of two candidate tumor suppressor genes within a 10 kb region on
RT chromosome 13q14, frequently deleted in chronic lymphocytic leukemia.";
RL Oncogene 15:2463-2473(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Liu Y., Cheng J., Lu Y., Wang G., Li K., Chen J., Li L.;
RT "Cloning and identification of human gene 6 transactivated by hepatitis B
RT virus X antigen.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-40.
RX PubMed=11161783; DOI=10.1006/geno.2000.6386;
RA Kapanadze B., Makeeva N., Corcoran M., Jareborg N., Hammarsund M.,
RA Baranova A., Zabarovsky E., Vorontsova O., Merup M., Gahrton G.,
RA Jansson M., Yankovsky N., Einhorn S., Oscier D., Grander D., Sangfelt O.;
RT "Comparative sequence analysis of a region on human chromosome 13q14,
RT frequently deleted in B-cell chronic lymphocytic leukemia, and its
RT homologous region on mouse chromosome 14.";
RL Genomics 70:327-334(2000).
CC -!- FUNCTION: May act as a tumor suppressor.
CC -!- INTERACTION:
CC O43261; Q92993: KAT5; NbExp=2; IntAct=EBI-710057, EBI-399080;
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA75515.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; Y15227; CAA75515.1; ALT_FRAME; mRNA.
DR EMBL; Y15381; CAA75600.1; -; Genomic_DNA.
DR EMBL; AF490255; AAO85463.1; -; mRNA.
DR EMBL; AL137060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471075; EAX08858.1; -; Genomic_DNA.
DR EMBL; BC020692; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AF328925; AAL95698.1; -; Genomic_DNA.
DR AlphaFoldDB; O43261; -.
DR IntAct; O43261; 19.
DR STRING; 9606.ENSP00000367422; -.
DR BioMuta; HGNC:13747; -.
DR PaxDb; O43261; -.
DR PRIDE; O43261; -.
DR UCSC; uc058xbn.1; human.
DR GeneCards; DLEU1; -.
DR HGNC; HGNC:13747; DLEU1.
DR MIM; 605765; gene.
DR neXtProt; NX_O43261; -.
DR eggNOG; ENOG502TI68; Eukaryota.
DR HOGENOM; CLU_2704229_0_0_1; -.
DR InParanoid; O43261; -.
DR PhylomeDB; O43261; -.
DR TreeFam; TF341071; -.
DR PathwayCommons; O43261; -.
DR SignaLink; O43261; -.
DR ChiTaRS; DLEU1; human.
DR Pharos; O43261; Tbio.
DR PRO; PR:O43261; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; O43261; protein.
DR Genevisible; O43261; HS.
PE 1: Evidence at protein level;
KW Reference proteome; Tumor suppressor.
FT CHAIN 1..78
FT /note="Leukemia-associated protein 1"
FT /id="PRO_0000084409"
SQ SEQUENCE 78 AA; 8962 MW; 19D780086C5FFF21 CRC64;
MRPCIWIHVH LKPPCRLVEL LPFSSALQGL SHLSLGTTLP VILPERNEEQ NLQELSHNAD
KYQMGDCCKE EIDDSIFY
