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ARFK_DICDI
ID   ARFK_DICDI              Reviewed;         188 AA.
AC   Q54V41;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=ADP-ribosylation factor K;
GN   Name=arrK; ORFNames=DDB_G0280633;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: GTP-binding protein that may be involved in protein
CC       trafficking. May modulate vesicle budding and uncoating within the
CC       Golgi apparatus (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000037; EAL67118.1; -; Genomic_DNA.
DR   RefSeq; XP_641090.1; XM_635998.1.
DR   AlphaFoldDB; Q54V41; -.
DR   SMR; Q54V41; -.
DR   STRING; 44689.DDB0229373; -.
DR   PaxDb; Q54V41; -.
DR   EnsemblProtists; EAL67118; EAL67118; DDB_G0280633.
DR   GeneID; 8622649; -.
DR   KEGG; ddi:DDB_G0280633; -.
DR   dictyBase; DDB_G0280633; arrK.
DR   eggNOG; KOG0070; Eukaryota.
DR   HOGENOM; CLU_040729_9_3_1; -.
DR   InParanoid; Q54V41; -.
DR   OMA; CRILMIG; -.
DR   PhylomeDB; Q54V41; -.
DR   Reactome; R-DDI-1660514; Synthesis of PIPs at the Golgi membrane.
DR   Reactome; R-DDI-5620916; VxPx cargo-targeting to cilium.
DR   Reactome; R-DDI-6807878; COPI-mediated anterograde transport.
DR   Reactome; R-DDI-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   PRO; PR:Q54V41; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR024156; Small_GTPase_ARF.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   PANTHER; PTHR11711; PTHR11711; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   3: Inferred from homology;
KW   ER-Golgi transport; Golgi apparatus; GTP-binding; Nucleotide-binding;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..188
FT                   /note="ADP-ribosylation factor K"
FT                   /id="PRO_0000328147"
FT   BINDING         34..40
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         75..79
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         134..137
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   188 AA;  21374 MW;  2F00B71E07D17BF7 CRC64;
     MLSEFFNSLA SFFSNIFSLF EGKKDTRILM IGLDGAGKST LLFKLKLGDV VLTIPTIGFN
     VETIVYKNLS MTVWDVGGQH KIRALWKHYY HGTNAIIFVV DSTDRERMDE VKEEIDNLLI
     QDELKGIQIL VLANKQDMNN AMNTAEIVNS LNLNSIKDRK WYVQPCSAIR SDGIYEGFDW
     VANSLNNK
 
 
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