ID   ARFL_ARATH              Reviewed;         593 AA.
AC   Q9XID4; Q5IRX5;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2004, sequence version 2.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Auxin response factor 12;
GN   Name=ARF12; OrderedLocusNames=At1g34310; ORFNames=F23M19.4;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=15659631; DOI=10.1105/tpc.104.028316;
RA   Okushima Y., Overvoorde P.J., Arima K., Alonso J.M., Chan A., Chang C.,
RA   Ecker J.R., Hughes B., Lui A., Nguyen D., Onodera C., Quach H., Smith A.,
RA   Yu G., Theologis A.;
RT   "Functional genomic analysis of the AUXIN RESPONSE FACTOR gene family
RT   members in Arabidopsis thaliana: unique and overlapping functions of ARF7
RT   and ARF19.";
RL   Plant Cell 17:444-463(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   GENE FAMILY, NOMENCLATURE, AND FUNCTION.
RX   PubMed=12036261; DOI=10.1023/a:1015207114117;
RA   Hagen G., Guilfoyle T.J.;
RT   "Auxin-responsive gene expression: genes, promoters and regulatory
RT   factors.";
RL   Plant Mol. Biol. 49:373-385(2002).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=18986826; DOI=10.1016/j.tplants.2008.09.006;
RA   Swaminathan K., Peterson K., Jack T.;
RT   "The plant B3 superfamily.";
RL   Trends Plant Sci. 13:647-655(2008).
CC   -!- FUNCTION: Auxin response factors (ARFs) are transcriptional factors
CC       that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the
CC       auxin-responsive promoter elements (AuxREs). Could act as
CC       transcriptional activator or repressor. Formation of heterodimers with
CC       Aux/IAA proteins may alter their ability to modulate early auxin
CC       response genes expression. {ECO:0000269|PubMed:12036261}.
CC   -!- SUBUNIT: Homodimers and heterodimers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: Interactions between auxin response factors (ARFs) and Aux/IAA
CC       proteins occur through their C-terminal dimerization domains III and
CC       IV.
CC   -!- SIMILARITY: Belongs to the ARF family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD39615.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY669792; AAT67076.1; -; mRNA.
DR   EMBL; AC007454; AAD39615.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE31695.1; -; Genomic_DNA.
DR   PIR; C86467; C86467.
DR   RefSeq; NP_174691.2; NM_103153.2.
DR   AlphaFoldDB; Q9XID4; -.
DR   SMR; Q9XID4; -.
DR   BioGRID; 25563; 9.
DR   IntAct; Q9XID4; 12.
DR   STRING; 3702.AT1G34310.1; -.
DR   PaxDb; Q9XID4; -.
DR   PRIDE; Q9XID4; -.
DR   EnsemblPlants; AT1G34310.1; AT1G34310.1; AT1G34310.
DR   GeneID; 840331; -.
DR   Gramene; AT1G34310.1; AT1G34310.1; AT1G34310.
DR   KEGG; ath:AT1G34310; -.
DR   Araport; AT1G34310; -.
DR   TAIR; locus:2026145; AT1G34310.
DR   eggNOG; ENOG502QTME; Eukaryota.
DR   HOGENOM; CLU_002626_4_4_1; -.
DR   OMA; IYNERMV; -.
DR   OrthoDB; 551703at2759; -.
DR   PhylomeDB; Q9XID4; -.
DR   PRO; PR:Q9XID4; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9XID4; baseline and differential.
DR   Genevisible; Q9XID4; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR   GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd10017; B3_DNA; 1.
DR   Gene3D; 2.40.330.10; -; 1.
DR   InterPro; IPR010525; ARF_dom.
DR   InterPro; IPR044835; ARF_plant.
DR   InterPro; IPR033389; AUX/IAA_dom.
DR   InterPro; IPR003340; B3_DNA-bd.
DR   InterPro; IPR015300; DNA-bd_pseudobarrel_sf.
DR   InterPro; IPR000270; PB1_dom.
DR   PANTHER; PTHR31384; PTHR31384; 1.
DR   Pfam; PF02309; AUX_IAA; 2.
DR   Pfam; PF06507; Auxin_resp; 1.
DR   Pfam; PF02362; B3; 1.
DR   SMART; SM01019; B3; 1.
DR   SUPFAM; SSF101936; SSF101936; 1.
DR   PROSITE; PS50863; B3; 1.
DR   PROSITE; PS51745; PB1; 1.
PE   2: Evidence at transcript level;
KW   Auxin signaling pathway; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..593
FT                   /note="Auxin response factor 12"
FT                   /id="PRO_0000111516"
FT   DOMAIN          511..592
FT                   /note="PB1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01081"
FT   DNA_BIND        126..228
FT                   /note="TF-B3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00326"
SQ   SEQUENCE   593 AA;  67218 MW;  01DCBAB5889B2ECA CRC64;
     MESGNVVNAQ PELSGIIDGS KSYVYEQLWK LCAGPLCDIP KLGEKVYYFP QGHIELVETS
     TREELNELQP ICDLPSKLQC RVIAIHLKVE NNSDETYAEI TLMPDTTQVV IPTQNENQFR
     PLVNSFTKVL TASDTSAHGG FFVPKKHAIE CLPSLDMSQP LPAQELLAID LHGNQWRFNH
     NYRGTPQRHL LTTGWNAFTT SKKLVAGDVI VFVRGETGEL RVGIRRARHQ QGNIPSSIVS
     IDCMRHGVVA SAKHAFDNQC MFTVVYKPRS SKFIVSYDKF LDAVNNKFNV GSRFTMRLEG
     DDFSERRCFG TIIGVSDFSP HWKCSEWRSL EVQWDEFTSF PGPKKVSPWD IEHLMPAINV
     PRSFLLKNKR LREVNEIGSS SSHLLPPILT QGQENEQLSV ASPMNISLRY RDATEDAMNP
     SKLLMSYPVQ PMPKLNYNNQ MVTEMEENIT TKTGTNFRLF GVTLDTPPVI KDPIEEIGSE
     ISKLTEGKKF GLSQTLRSPT EIQNKQFSSS RTCTKVQMQG VTIGRAVDLS VLNGYDQLIL
     ELEKLFDIKG QLQTRNQWEI AFTDSDEDKM LVGDDPWPEF CNMVKKIFIQ KRR