ID   ARFM_BACSU              Reviewed;         158 AA.
AC   P46910;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Probable transcription regulator ArfM;
DE   AltName: Full=Anaerobic respiration and fermentation modulator;
GN   Name=arfM; OrderedLocusNames=BSU37290;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9353933; DOI=10.1099/00221287-143-10-3313;
RA   Presecan E., Moszer I., Boursier L., Cruz Ramos H., De La Fuente V.,
RA   Hullo M.-F., Lelong C., Schleich S., Sekowska A., Song B.H., Villani G.,
RA   Kunst F., Danchin A., Glaser P.;
RT   "The Bacillus subtilis genome from gerBC (311 degrees) to licR (334
RT   degrees).";
RL   Microbiology 143:3313-3328(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   FUNCTION.
RC   STRAIN=168;
RX   PubMed=11698370; DOI=10.1128/jb.183.23.6815-6821.2001;
RA   Marino M., Cruz Ramos H., Hoffmann T., Glaser P., Jahn D.;
RT   "Modulation of anaerobic energy metabolism of Bacillus subtilis by arfM
RT   (ywiD).";
RL   J. Bacteriol. 183:6815-6821(2001).
CC   -!- FUNCTION: Activates, in anaerobic conditions, the transcription of the
CC       fermentative operons lctEP and alsDS, of the hmp gene encoding a
CC       flavohemoglobin-like protein, the nitrite reductase operon nasDE and
CC       the heme biosynthesis genes hemN and hemZ.
CC       {ECO:0000269|PubMed:11698370}.
CC   -!- INDUCTION: By fnr. Autorepressed.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z49884; CAA90044.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15757.1; -; Genomic_DNA.
DR   PIR; S60084; S60084.
DR   RefSeq; NP_391610.1; NC_000964.3.
DR   RefSeq; WP_003243032.1; NZ_JNCM01000034.1.
DR   AlphaFoldDB; P46910; -.
DR   SMR; P46910; -.
DR   STRING; 224308.BSU37290; -.
DR   PaxDb; P46910; -.
DR   EnsemblBacteria; CAB15757; CAB15757; BSU_37290.
DR   GeneID; 937058; -.
DR   KEGG; bsu:BSU37290; -.
DR   PATRIC; fig|224308.179.peg.4040; -.
DR   eggNOG; COG0664; Bacteria.
DR   OMA; MMSYHPR; -.
DR   BioCyc; BSUB:BSU37290-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   SUPFAM; SSF51206; SSF51206; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..158
FT                   /note="Probable transcription regulator ArfM"
FT                   /id="PRO_0000064664"
SQ   SEQUENCE   158 AA;  18136 MW;  1B25EE372EAC0A77 CRC64;
     MNQCDYLLFL KQLPMFNEVP LSIVETLLKN GTFIRGSCDQ SPSFLHSQSV YIVLKGSVRF
     MDTRLPEGSK TVALWEKGDV FPIDEKGGLY LSPFISVNAT SDILILNIPY YIFKKMMSYH
     PQLQMNFLAM LQQNVFCSYQ LFLRYLHTSQ DENAEPGS