ARFP_ARATH
ID ARFP_ARATH Reviewed; 670 AA.
AC Q93YR9; B2CTE3; B2CTE4; Q9SZW1;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 142.
DE RecName: Full=Auxin response factor 16;
GN Name=ARF16; OrderedLocusNames=At4g30080; ORFNames=F6G3.110;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 372-531, AND VARIANT PRO-471 DEL.
RC STRAIN=cv. Ag-0, cv. An-1, cv. Bay-0, cv. Br-0, cv. C24, cv. Ct-1,
RC cv. Cvi-1, cv. Edi-0, cv. Ei-2, cv. Ga-0, cv. Gy-0, cv. Kas-2, cv. Ll-0,
RC cv. Mrk-0, cv. Ms-0, cv. Mt-0, cv. Nd-1, cv. Nok-3, cv. Oy-0, cv. Sorbo,
RC cv. Wa-1, cv. Wassilewskija, cv. Wei-0, and cv. Wt-5;
RX PubMed=18305205; DOI=10.1104/pp.108.116582;
RA Ehrenreich I.M., Purugganan M.D.;
RT "Sequence variation of microRNAs and their binding sites in Arabidopsis.";
RL Plant Physiol. 146:1974-1982(2008).
RN [5]
RP GENE FAMILY, NOMENCLATURE, AND FUNCTION.
RX PubMed=12036261; DOI=10.1023/a:1015207114117;
RA Hagen G., Guilfoyle T.J.;
RT "Auxin-responsive gene expression: genes, promoters and regulatory
RT factors.";
RL Plant Mol. Biol. 49:373-385(2002).
RN [6]
RP GENE FAMILY.
RX PubMed=18986826; DOI=10.1016/j.tplants.2008.09.006;
RA Swaminathan K., Peterson K., Jack T.;
RT "The plant B3 superfamily.";
RL Trends Plant Sci. 13:647-655(2008).
CC -!- FUNCTION: Auxin response factors (ARFs) are transcriptional factors
CC that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the
CC auxin-responsive promoter elements (AuxREs). Could act as
CC transcriptional activator or repressor. Formation of heterodimers with
CC Aux/IAA proteins may alter their ability to modulate early auxin
CC response genes expression. {ECO:0000269|PubMed:12036261}.
CC -!- SUBUNIT: Homodimers and heterodimers. {ECO:0000250}.
CC -!- INTERACTION:
CC Q93YR9; Q9MAI5: ERF8; NbExp=3; IntAct=EBI-3947588, EBI-2000137;
CC Q93YR9; Q8H174: IAA31; NbExp=10; IntAct=EBI-3947588, EBI-3946408;
CC Q93YR9; Q9FKM7: IAA33; NbExp=7; IntAct=EBI-3947588, EBI-3946739;
CC Q93YR9; P33078: IAA5; NbExp=4; IntAct=EBI-3947588, EBI-3946487;
CC Q93YR9; Q9FX36: MYB54; NbExp=3; IntAct=EBI-3947588, EBI-25511270;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- DOMAIN: Interactions between auxin response factors (ARFs) and Aux/IAA
CC proteins occur through their C-terminal dimerization domains III and
CC IV.
CC -!- SIMILARITY: Belongs to the ARF family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB43843.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB81001.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL078464; CAB43843.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161576; CAB81001.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE85718.1; -; Genomic_DNA.
DR EMBL; AY059792; AAL24140.1; -; mRNA.
DR EMBL; AY091198; AAM14137.1; -; mRNA.
DR EMBL; EU550120; ACB30906.1; -; Genomic_DNA.
DR EMBL; EU550121; ACB30907.1; -; Genomic_DNA.
DR EMBL; EU550122; ACB30908.1; -; Genomic_DNA.
DR EMBL; EU550123; ACB30909.1; -; Genomic_DNA.
DR EMBL; EU550124; ACB30910.1; -; Genomic_DNA.
DR EMBL; EU550125; ACB30911.1; -; Genomic_DNA.
DR EMBL; EU550126; ACB30912.1; -; Genomic_DNA.
DR EMBL; EU550127; ACB30913.1; -; Genomic_DNA.
DR EMBL; EU550128; ACB30914.1; -; Genomic_DNA.
DR EMBL; EU550129; ACB30915.1; -; Genomic_DNA.
DR EMBL; EU550130; ACB30916.1; -; Genomic_DNA.
DR EMBL; EU550131; ACB30917.1; -; Genomic_DNA.
DR EMBL; EU550132; ACB30918.1; -; Genomic_DNA.
DR EMBL; EU550133; ACB30919.1; -; Genomic_DNA.
DR EMBL; EU550134; ACB30920.1; -; Genomic_DNA.
DR EMBL; EU550135; ACB30921.1; -; Genomic_DNA.
DR EMBL; EU550136; ACB30922.1; -; Genomic_DNA.
DR EMBL; EU550137; ACB30923.1; -; Genomic_DNA.
DR EMBL; EU550138; ACB30924.1; -; Genomic_DNA.
DR EMBL; EU550139; ACB30925.1; -; Genomic_DNA.
DR EMBL; EU550140; ACB30926.1; -; Genomic_DNA.
DR EMBL; EU550141; ACB30927.1; -; Genomic_DNA.
DR EMBL; EU550142; ACB30928.1; -; Genomic_DNA.
DR EMBL; EU550143; ACB30929.1; -; Genomic_DNA.
DR PIR; T08984; T08984.
DR RefSeq; NP_567841.1; NM_119154.5.
DR AlphaFoldDB; Q93YR9; -.
DR SMR; Q93YR9; -.
DR BioGRID; 14418; 11.
DR IntAct; Q93YR9; 21.
DR STRING; 3702.AT4G30080.1; -.
DR PaxDb; Q93YR9; -.
DR PRIDE; Q93YR9; -.
DR ProteomicsDB; 246992; -.
DR EnsemblPlants; AT4G30080.1; AT4G30080.1; AT4G30080.
DR GeneID; 829131; -.
DR Gramene; AT4G30080.1; AT4G30080.1; AT4G30080.
DR KEGG; ath:AT4G30080; -.
DR Araport; AT4G30080; -.
DR TAIR; locus:2126460; AT4G30080.
DR eggNOG; ENOG502QTRP; Eukaryota.
DR HOGENOM; CLU_002626_3_5_1; -.
DR InParanoid; Q93YR9; -.
DR OMA; IGNGPEY; -.
DR OrthoDB; 216379at2759; -.
DR PhylomeDB; Q93YR9; -.
DR PRO; PR:Q93YR9; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q93YR9; baseline and differential.
DR Genevisible; Q93YR9; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0035198; F:miRNA binding; ISS:TAIR.
DR GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IGI:TAIR.
DR GO; GO:0007389; P:pattern specification process; IDA:TAIR.
DR GO; GO:0009733; P:response to auxin; IEP:TAIR.
DR GO; GO:0048829; P:root cap development; IMP:TAIR.
DR CDD; cd10017; B3_DNA; 1.
DR Gene3D; 2.40.330.10; -; 1.
DR InterPro; IPR010525; ARF_dom.
DR InterPro; IPR044835; ARF_plant.
DR InterPro; IPR003340; B3_DNA-bd.
DR InterPro; IPR015300; DNA-bd_pseudobarrel_sf.
DR InterPro; IPR000270; PB1_dom.
DR PANTHER; PTHR31384; PTHR31384; 1.
DR Pfam; PF06507; Auxin_resp; 1.
DR Pfam; PF02362; B3; 1.
DR SMART; SM01019; B3; 1.
DR SUPFAM; SSF101936; SSF101936; 1.
DR PROSITE; PS50863; B3; 1.
DR PROSITE; PS51745; PB1; 1.
PE 1: Evidence at protein level;
KW Auxin signaling pathway; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..670
FT /note="Auxin response factor 16"
FT /id="PRO_0000111520"
FT DOMAIN 584..664
FT /note="PB1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01081"
FT DNA_BIND 120..222
FT /note="TF-B3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00326"
FT REGION 545..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 477
FT /note="Missing (in strain: cv. Ag-0, cv. An-1, cv. Bay-0,
FT cv. Br-0, cv. Cvi-0, cv. Edi-0, cv. Gy-0, cv. Kas-2, cv.
FT Oy-0 and cv. Sorbo)"
SQ SEQUENCE 670 AA; 73979 MW; DD5F5F761805457F CRC64;
MINVMNPMKG GTEKGLDPQL WHACAGGMVR MPPMNSKVFY FPQGHAENAY DCVDFGNLPI
PPMVLCRVLA IKYMADAESD EVFAKLRLIP LKDDEYVDHE YGDGEDSNGF ESNSEKTPSF
AKTLTQSDAN NGGGFSVPRY CAETIFPRLD YNAEPPVQTI LAKDVHGDVW KFRHIYRGTP
RRHLLTTGWS NFVNQKKLVA GDSIVFMRAE NGDLCVGIRR AKRGGIGNGP EYSAGWNPIG
GSCGYSSLLR EDESNSLRRS NCSLADRKGK VTAESVIEAA TLAISGRPFE VVYYPRASTS
EFCVKALDAR AAMRIPWCSG MRFKMAFETE DSSRISWFMG TVSAVNVSDP IRWPNSPWRL
LQVAWDEPDL LQNVKRVNPW LVELVSNVHP IPLTSFSPPR KKMRLPQHPD YNNLINSIPV
PSFPSNPLIR SSPLSSVLDN VPVGLQGARH NAHQYYGLSS SDLHHYYLNR PPPPPPPSSL
QLSPSLGLRN IDTKNEKGFC FLTMGTTPCN DTKSKKSHIV LFGKLILPEE QLSEKGSTDT
ANIEKTQISS GGSNQNGVAG REFSSSDEGS PCSKKVHDAS GLETGHCKVF MESDDVGRTL
DLSVLGSYEE LSRKLSDMFG IKKSEMLSSV LYRDASGAIK YAGNEPFSEF LKTARRLTIL
TEQGSESVVV
