ID   ARFRP_PONAB             Reviewed;         201 AA.
AC   Q5R579;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=ADP-ribosylation factor-related protein 1;
DE            Short=ARF-related protein 1;
GN   Name=ARFRP1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Trans-Golgi-associated GTPase that regulates protein sorting.
CC       Controls the targeting of ARL1 and its effector to the trans-Golgi.
CC       Required for the lipidation of chylomicrons in the intestine and
CC       required for VLDL lipidation in the liver.
CC       {ECO:0000250|UniProtKB:Q8BXL7}.
CC   -!- SUBUNIT: Interacts with SYS1. {ECO:0000250|UniProtKB:Q13795}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus. Golgi apparatus, trans-Golgi
CC       network {ECO:0000250|UniProtKB:Q8BXL7}. Note=Located in the trans-Golgi
CC       in the GTP-bound active state. {ECO:0000250|UniProtKB:Q8BXL7}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
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DR   EMBL; CR860985; CAH93087.1; -; mRNA.
DR   RefSeq; XP_003779452.1; XM_003779404.2.
DR   RefSeq; XP_009232100.1; XM_009233825.1.
DR   RefSeq; XP_009232101.1; XM_009233826.1.
DR   RefSeq; XP_009232102.1; XM_009233827.1.
DR   AlphaFoldDB; Q5R579; -.
DR   SMR; Q5R579; -.
DR   STRING; 9601.ENSPPYP00000012564; -.
DR   Ensembl; ENSPPYT00000013060; ENSPPYP00000012564; ENSPPYG00000011245.
DR   GeneID; 100444340; -.
DR   KEGG; pon:100444340; -.
DR   CTD; 10139; -.
DR   eggNOG; KOG0076; Eukaryota.
DR   GeneTree; ENSGT00940000156407; -.
DR   HOGENOM; CLU_040729_7_2_1; -.
DR   InParanoid; Q5R579; -.
DR   OMA; QCHGIIF; -.
DR   OrthoDB; 1271528at2759; -.
DR   TreeFam; TF105788; -.
DR   Proteomes; UP000001595; Chromosome 20.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0016020; C:membrane; IEA:Ensembl.
DR   GO; GO:0005802; C:trans-Golgi network; IEA:Ensembl.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007369; P:gastrulation; IEA:Ensembl.
DR   GO; GO:0043001; P:Golgi to plasma membrane protein transport; IEA:Ensembl.
DR   GO; GO:0034067; P:protein localization to Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:Ensembl.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   Pfam; PF00025; Arf; 1.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Golgi apparatus; GTP-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..201
FT                   /note="ADP-ribosylation factor-related protein 1"
FT                   /id="PRO_0000207489"
FT   BINDING         24..31
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         75..79
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         134..137
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q13795"
SQ   SEQUENCE   201 AA;  22614 MW;  8A75CF7A3B268158 CRC64;
     MYTLLSGLYK YMFQKDEYCI LILGLDNAGK TTFLEQSKTR FNKNYKGMSL SKITTTVGLN
     IGTVDVGKAR LMFWDLGGQE ELQSLWDKYY AECHGVIYVI DSTDEERLAE SKQAFEKVVT
     SEALCGVPVL VLANKQDVET CLSIPDIKTA FSDCTSKIGR RDCLTQACSA LTGKGVREGI
     EWMVKCVVRN VHRPPRQRDI T