ID   ARFRP_RAT               Reviewed;         201 AA.
AC   Q63055;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=ADP-ribosylation factor-related protein 1;
DE            Short=ARF-related protein 1;
DE            Short=ARP;
GN   Name=Arfrp1; Synonyms=Arp1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Heart muscle;
RX   PubMed=8530503; DOI=10.1074/jbc.270.51.30657;
RA   Schuermann A., Massmann S., Joost H.-G.;
RT   "ARP is a plasma membrane-associated Ras-related GTPase with remote
RT   similarity to the family of ADP-ribosylation factors.";
RL   J. Biol. Chem. 270:30657-30663(1995).
CC   -!- FUNCTION: Trans-Golgi-associated GTPase that regulates protein sorting.
CC       Controls the targeting of ARL1 and its effector to the trans-Golgi.
CC       Required for the lipidation of chylomicrons in the intestine and
CC       required for VLDL lipidation in the liver.
CC       {ECO:0000250|UniProtKB:Q8BXL7}.
CC   -!- SUBUNIT: Interacts with SYS1. {ECO:0000250|UniProtKB:Q13795}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus. Golgi apparatus, trans-Golgi
CC       network {ECO:0000250|UniProtKB:Q8BXL7}. Note=Located in the trans-Golgi
CC       in the GTP-bound active state. {ECO:0000250|UniProtKB:Q8BXL7}.
CC   -!- TISSUE SPECIFICITY: Found in most tissues.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
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DR   EMBL; X78603; CAA55337.1; -; mRNA.
DR   RefSeq; NP_446432.1; NM_053980.1.
DR   RefSeq; XP_006235780.1; XM_006235718.2.
DR   AlphaFoldDB; Q63055; -.
DR   SMR; Q63055; -.
DR   STRING; 10116.ENSRNOP00000019038; -.
DR   PhosphoSitePlus; Q63055; -.
DR   jPOST; Q63055; -.
DR   PaxDb; Q63055; -.
DR   PRIDE; Q63055; -.
DR   GeneID; 117051; -.
DR   KEGG; rno:117051; -.
DR   UCSC; RGD:621683; rat.
DR   CTD; 10139; -.
DR   RGD; 621683; Arfrp1.
DR   VEuPathDB; HostDB:ENSRNOG00000013992; -.
DR   eggNOG; KOG0076; Eukaryota.
DR   HOGENOM; CLU_040729_7_2_1; -.
DR   InParanoid; Q63055; -.
DR   OMA; QCHGIIF; -.
DR   OrthoDB; 1271528at2759; -.
DR   PhylomeDB; Q63055; -.
DR   TreeFam; TF105788; -.
DR   Reactome; R-RNO-6811440; Retrograde transport at the Trans-Golgi-Network.
DR   PRO; PR:Q63055; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000013992; Expressed in thymus and 20 other tissues.
DR   Genevisible; Q63055; RN.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; ISO:RGD.
DR   GO; GO:0005802; C:trans-Golgi network; ISO:RGD.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0007369; P:gastrulation; ISO:RGD.
DR   GO; GO:0043001; P:Golgi to plasma membrane protein transport; ISO:RGD.
DR   GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR   GO; GO:0034067; P:protein localization to Golgi apparatus; ISO:RGD.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; ISO:RGD.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   Pfam; PF00025; Arf; 1.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Golgi apparatus; GTP-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..201
FT                   /note="ADP-ribosylation factor-related protein 1"
FT                   /id="PRO_0000207490"
FT   BINDING         24..31
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         75..79
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         134..137
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q13795"
SQ   SEQUENCE   201 AA;  22659 MW;  7BB6D213946F597E CRC64;
     MYTLLSGLYK YMFQKDEYCI LILGLDNAGK TTFLEQSKTR FNKNYKGMSL SKITTTVGLN
     IGTVDVGKAR LMFWDLGGQE ELQSLWDKYY AECHGVIYVI DSTDEERLSE SKEAFEKVVS
     SEALDGVPIL VLANKQDVET CLSIPDIKTA FSDCTCKIGR RDCLTQACSA LTGKGVREGI
     EWMVKCVVRN VHRPPRQRDI T