ID   ARFV_ARATH              Reviewed;         598 AA.
AC   Q9C8N7; Q5IRX1;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2004, sequence version 2.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Auxin response factor 22;
GN   Name=ARF22; OrderedLocusNames=At1g34390; ORFNames=F7P12.6;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=15659631; DOI=10.1105/tpc.104.028316;
RA   Okushima Y., Overvoorde P.J., Arima K., Alonso J.M., Chan A., Chang C.,
RA   Ecker J.R., Hughes B., Lui A., Nguyen D., Onodera C., Quach H., Smith A.,
RA   Yu G., Theologis A.;
RT   "Functional genomic analysis of the AUXIN RESPONSE FACTOR gene family
RT   members in Arabidopsis thaliana: unique and overlapping functions of ARF7
RT   and ARF19.";
RL   Plant Cell 17:444-463(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   GENE FAMILY, NOMENCLATURE, AND FUNCTION.
RX   PubMed=12036261; DOI=10.1023/a:1015207114117;
RA   Hagen G., Guilfoyle T.J.;
RT   "Auxin-responsive gene expression: genes, promoters and regulatory
RT   factors.";
RL   Plant Mol. Biol. 49:373-385(2002).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=18986826; DOI=10.1016/j.tplants.2008.09.006;
RA   Swaminathan K., Peterson K., Jack T.;
RT   "The plant B3 superfamily.";
RL   Trends Plant Sci. 13:647-655(2008).
CC   -!- FUNCTION: Auxin response factors (ARFs) are transcriptional factors
CC       that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the
CC       auxin-responsive promoter elements (AuxREs). Could act as
CC       transcriptional activator or repressor. Formation of heterodimers with
CC       Aux/IAA proteins may alter their ability to modulate early auxin
CC       response genes expression. {ECO:0000269|PubMed:12036261}.
CC   -!- SUBUNIT: Homodimers and heterodimers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: Interactions between auxin response factors (ARFs) and Aux/IAA
CC       proteins occur through their C-terminal dimerization domains III and
CC       IV.
CC   -!- SIMILARITY: Belongs to the ARF family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG51894.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AY669796; AAT67080.1; -; mRNA.
DR   EMBL; AC023913; AAG51894.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE31708.1; -; Genomic_DNA.
DR   PIR; C86468; C86468.
DR   RefSeq; NP_174699.2; NM_103162.2.
DR   AlphaFoldDB; Q9C8N7; -.
DR   SMR; Q9C8N7; -.
DR   BioGRID; 25573; 11.
DR   IntAct; Q9C8N7; 10.
DR   STRING; 3702.AT1G34390.1; -.
DR   PaxDb; Q9C8N7; -.
DR   PRIDE; Q9C8N7; -.
DR   ProteomicsDB; 240886; -.
DR   EnsemblPlants; AT1G34390.1; AT1G34390.1; AT1G34390.
DR   GeneID; 840341; -.
DR   Gramene; AT1G34390.1; AT1G34390.1; AT1G34390.
DR   KEGG; ath:AT1G34390; -.
DR   Araport; AT1G34390; -.
DR   TAIR; locus:2036288; AT1G34390.
DR   eggNOG; ENOG502QTME; Eukaryota.
DR   HOGENOM; CLU_002626_4_4_1; -.
DR   OMA; YWKGSEW; -.
DR   OrthoDB; 551703at2759; -.
DR   PhylomeDB; Q9C8N7; -.
DR   PRO; PR:Q9C8N7; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9C8N7; differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR   GO; GO:0009734; P:auxin-activated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR   CDD; cd10017; B3_DNA; 1.
DR   Gene3D; 2.40.330.10; -; 1.
DR   InterPro; IPR010525; ARF_dom.
DR   InterPro; IPR044835; ARF_plant.
DR   InterPro; IPR033389; AUX/IAA_dom.
DR   InterPro; IPR003340; B3_DNA-bd.
DR   InterPro; IPR015300; DNA-bd_pseudobarrel_sf.
DR   InterPro; IPR000270; PB1_dom.
DR   PANTHER; PTHR31384; PTHR31384; 1.
DR   Pfam; PF02309; AUX_IAA; 2.
DR   Pfam; PF06507; Auxin_resp; 1.
DR   Pfam; PF02362; B3; 1.
DR   SMART; SM01019; B3; 1.
DR   SUPFAM; SSF101936; SSF101936; 1.
DR   PROSITE; PS50863; B3; 1.
DR   PROSITE; PS51745; PB1; 1.
PE   2: Evidence at transcript level;
KW   Auxin signaling pathway; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..598
FT                   /note="Auxin response factor 22"
FT                   /id="PRO_0000111526"
FT   DOMAIN          509..590
FT                   /note="PB1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01081"
FT   DNA_BIND        124..226
FT                   /note="TF-B3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00326"
SQ   SEQUENCE   598 AA;  67733 MW;  1F9A79C4BD932D94 CRC64;
     MESGNIVNAQ PELSGIIDGS KSYMYEQLWK LCAGPLCDIP KLGEKIYYFP QGNIELVEAS
     TREELNELKP ICDLPSKLQC RVIAIQLKVE NNSDETYAEI TLMPDTTQVV IPTQNENQFR
     PLVNSFTKVL TASDTSGGFF VPKKHAIECL PPLDMSQPLP TQELLATDLH GNQWRFNHNY
     RGTPQRHLLT TGWNAFTTSK KLVAGDVIVF VRGETGELRV GIRRAGHQQG NIPSSIISIE
     SMRHGVIASA KHAFDNQCMF IVVYKPRSSQ FIVSYDKFLD AVNNKFNVGS RFTMRFEGDD
     FSERRYFGTI IGVSDFSPHW KCSEWRNLEV QWDEFASFSR PNKVSPWEIE HLMPALNVPR
     PSLLKNKRLR EVNEIGSSSS HLLPPILTQG QEIGQLSVAS PMNISLTYRD TTEDVMNPSR
     LLMSYPVQPM PKLNYNNQMV TQIEENITTK TGTNFRLFGV SLVTPSVIKD PIEEIGSEIS
     KLTEGKKFGQ SQTLRSPTEI QSKQFSSTRT CTKVQMQGVT IERAVDLSVL NGYDQLILEL
     EELFDLKGQL QTRNQWEIAF TDSDDDKMLV GDDPWPEFCN MVKKILIFKR GGQKLEVQ