LEU5_YEAST
ID LEU5_YEAST Reviewed; 357 AA.
AC P38702; D3DKR9;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Mitochondrial carrier protein LEU5;
GN Name=LEU5; OrderedLocusNames=YHR002W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091229; DOI=10.1126/science.8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA Waterston R., Wilson R., Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=11158296; DOI=10.1128/mcb.21.4.1089-1097.2001;
RA Prohl C., Pelzer W., Diekert K., Kmita H., Bedekovics T., Kispal G.,
RA Lill R.;
RT "The yeast mitochondrial carrier Leu5p and its human homologue Graves'
RT disease protein are required for accumulation of coenzyme A in the
RT matrix.";
RL Mol. Cell. Biol. 21:1089-1097(2001).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=16823961; DOI=10.1021/pr050477f;
RA Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.;
RT "Toward the complete yeast mitochondrial proteome: multidimensional
RT separation techniques for mitochondrial proteomics.";
RL J. Proteome Res. 5:1543-1554(2006).
CC -!- FUNCTION: Required for the accumulation of coenzyme A in the
CC mitochondrial matrix. {ECO:0000269|PubMed:11158296}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:11158296, ECO:0000269|PubMed:16823961}; Multi-pass
CC membrane protein {ECO:0000269|PubMed:11158296}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; U10555; AAB68424.1; -; Genomic_DNA.
DR EMBL; BK006934; DAA06689.1; -; Genomic_DNA.
DR PIR; S46795; S46795.
DR RefSeq; NP_011865.1; NM_001179132.1.
DR AlphaFoldDB; P38702; -.
DR SMR; P38702; -.
DR BioGRID; 36427; 123.
DR DIP; DIP-8164N; -.
DR STRING; 4932.YHR002W; -.
DR TCDB; 2.A.29.12.4; the mitochondrial carrier (mc) family.
DR MaxQB; P38702; -.
DR PaxDb; P38702; -.
DR PRIDE; P38702; -.
DR EnsemblFungi; YHR002W_mRNA; YHR002W; YHR002W.
DR GeneID; 856391; -.
DR KEGG; sce:YHR002W; -.
DR SGD; S000001044; LEU5.
DR VEuPathDB; FungiDB:YHR002W; -.
DR eggNOG; KOG0752; Eukaryota.
DR GeneTree; ENSGT00940000157520; -.
DR HOGENOM; CLU_015166_10_0_1; -.
DR InParanoid; P38702; -.
DR OMA; VYERMKW; -.
DR BioCyc; YEAST:G3O-31067-MON; -.
DR Reactome; R-SCE-196783; Coenzyme A biosynthesis.
DR PRO; PR:P38702; -.
DR Proteomes; UP000002311; Chromosome VIII.
DR RNAct; P38702; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0015228; F:coenzyme A transmembrane transporter activity; IMP:SGD.
DR GO; GO:0015880; P:coenzyme A transport; IMP:SGD.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR002167; Graves_DC.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00928; GRAVESDC.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..357
FT /note="Mitochondrial carrier protein LEU5"
FT /id="PRO_0000090683"
FT TRANSMEM 31..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..119
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..153
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..285
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..347
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 31..122
FT /note="Solcar 1"
FT REPEAT 130..231
FT /note="Solcar 2"
FT REPEAT 262..354
FT /note="Solcar 3"
SQ SEQUENCE 357 AA; 40825 MW; 16266B2CD4B996D5 CRC64;
MTRDSPDSND SYKHINKNTT QKTSFDRNSF DYIVRSGLAG GISGSCAKTL IAPLDRIKIL
FQTSNPHYTK YTGSLIGLVE AAKHIWINDG VRGFFQGHSA TLLRIFPYAA VKFVAYEQIR
NTLIPSKEFE SHWRRLVSGS LAGLCSVFIT YPLDLVRVRL AYETEHKRVK LGRIIKKIYK
EPASATLIKN DYIPNWFCHW CNFYRGYVPT VLGMIPYAGV SFFAHDLLHD VLKSPFFAPY
SVLELSEDDE LERVQKKQRR PLRTWAELIS GGLAGMASQT AAYPFEIIRR RLQVSALSPK
TMYDHKFQSI SEIAHIIFKE RGVRGFFVGL SIGYIKVTPM VACSFFVYER MKWNFGI
