ID   ARF_AJECA               Reviewed;         183 AA.
AC   P34727;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=ADP-ribosylation factor;
GN   Name=ARF;
OS   Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=5037;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND MYRISTOYLATION AT GLY-2.
RC   STRAIN=ATCC 26032 / G217B;
RX   PubMed=8300631; DOI=10.1016/s0021-9258(17)42038-2;
RA   Lodge J.K., Johnson R.L., Weinberg R.A., Gordon J.I.;
RT   "Comparison of myristoyl-CoA:protein N-myristoyltransferases from three
RT   pathogenic fungi: Cryptococcus neoformans, Histoplasma capsulatum, and
RT   Candida albicans.";
RL   J. Biol. Chem. 269:2996-3009(1994).
CC   -!- FUNCTION: GTP-binding protein involved in protein trafficking; may
CC       modulate vesicle budding and uncoating within the Golgi apparatus.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC       {ECO:0000305}.
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DR   EMBL; L25117; AAA17548.1; -; Unassigned_DNA.
DR   PIR; D49993; D49993.
DR   AlphaFoldDB; P34727; -.
DR   SMR; P34727; -.
DR   iPTMnet; P34727; -.
DR   PRIDE; P34727; -.
DR   OMA; LWRILNI; -.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   CDD; cd04150; Arf1_5_like; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR045872; Arf1-5-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR024156; Small_GTPase_ARF.
DR   InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR   PANTHER; PTHR11711; PTHR11711; 1.
DR   Pfam; PF00025; Arf; 1.
DR   PRINTS; PR00328; SAR1GTPBP.
DR   SMART; SM00178; SAR; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51417; ARF; 1.
PE   1: Evidence at protein level;
KW   ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein; Myristate;
KW   Nucleotide-binding; Protein transport; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..183
FT                   /note="ADP-ribosylation factor"
FT                   /id="PRO_0000207410"
FT   BINDING         24..31
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         67..71
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         126..129
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000269|PubMed:8300631"
SQ   SEQUENCE   183 AA;  20912 MW;  EC117B6C589DF3C7 CRC64;
     MGMAFSKLFD RIWGKKEMRI LMVGLDAAGK TTILYKLKLG EIVTTIPTIG FNVETVEYKN
     IQFTVWDVGG QDKIRPLWRH YFQNTQGIIF VVDSNDRDRV VEAREELQRM LNEDELRDAL
     LLVFANKQDL PNAMSPAEIT QQLGLQSLTR RAWYIQSTCA TTGDGLYEGL EWLANALKKA
     GHE