ARG13_NEUCR
ID ARG13_NEUCR Reviewed; 363 AA.
AC Q01356; Q7RVK7;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Amino-acid transporter arg-13;
GN Name=arg-13; ORFNames=NCU02802;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BDA;
RX PubMed=8807290; DOI=10.1093/genetics/143.3.1163;
RA Liu Q., Dunlap J.C.;
RT "Isolation and analysis of the arg-13 gene of Neurospora crassa.";
RL Genetics 143:1163-1174(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Liu Q., Luo X.;
RT "Phenotypic rescue of Saccharomyces cerevisiae arg11 mutant by Neurospora
RT crassa arg-13 cDNA.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Required for arginine biosynthesis. May participate in the
CC export of matrix-made ornithine into the cytosol (Potential).
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
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DR EMBL; L36378; AAC37500.1; -; Genomic_DNA.
DR EMBL; AF279268; AAF87777.1; -; mRNA.
DR EMBL; CM002236; EAA35222.1; -; Genomic_DNA.
DR PIR; T47240; T47240.
DR RefSeq; XP_964458.1; XM_959365.2.
DR AlphaFoldDB; Q01356; -.
DR SMR; Q01356; -.
DR STRING; 5141.EFNCRP00000002367; -.
DR TCDB; 2.A.29.9.1; the mitochondrial carrier (mc) family.
DR EnsemblFungi; EAA35222; EAA35222; NCU02802.
DR GeneID; 3880622; -.
DR KEGG; ncr:NCU02802; -.
DR VEuPathDB; FungiDB:NCU02802; -.
DR HOGENOM; CLU_015166_16_3_1; -.
DR InParanoid; Q01356; -.
DR OMA; PIDCFRQ; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0000064; F:L-ornithine transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1990575; P:mitochondrial L-ornithine transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; -; 2.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..363
FT /note="Amino-acid transporter arg-13"
FT /id="PRO_0000090680"
FT TRANSMEM 40..56
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..125
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..224
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..283
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..353
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 40..128
FT /note="Solcar 1"
FT REPEAT 141..233
FT /note="Solcar 2"
FT REPEAT 260..359
FT /note="Solcar 3"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 363 AA; 39401 MW; 8B87A937F6D37DC0 CRC64;
MDSVPAQTHQ GFKEAGAASA SHLTTTTSLP TKVESRTAVM EALEDIVYGS AAGIVGKYIE
YPFDTVKVRL QSQPDHLPLR YTGPLDCFRQ SIRADGFLGL YRGISAPLVG AALENSSLFF
FERIGRSLLY SSGFAPRDSE LSLSALWFTG GFSGAFTSLI LTPVELVKCK IQVPDEPGGA
GARQRQLKPI PVIKEIFRHE GLRGFWHGQL GTLIREAGGC AAWFGSKETT SKWFRGRNER
ALLKRGASQE EVVASRERPL PLWQQAIAGA SAGMSYNFLF FPADTVKSRM QTSPIGGGGD
NGGKGAATMM PKKSFGEEAR ALWKQAGIKG FYRGCGITVL RSAPSSAFIF MVYDGLKKYF
PMA
