ARG35_HUMAN
ID ARG35_HUMAN Reviewed; 484 AA.
AC A5YM69; Q6ZUI2;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Rho guanine nucleotide exchange factor 35;
DE AltName: Full=Rho guanine nucleotide exchange factor 5-like protein;
GN Name=ARHGEF35; Synonyms=ARHGEF5L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Schupp I.;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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DR EMBL; EF560743; ABQ59053.1; -; mRNA.
DR EMBL; AK125680; BAC86243.1; -; mRNA.
DR EMBL; BC136868; AAI36869.1; -; mRNA.
DR EMBL; BC136878; AAI36879.1; -; mRNA.
DR CCDS; CCDS34770.1; -.
DR RefSeq; NP_001003702.2; NM_001003702.2.
DR RefSeq; XP_016885946.1; XM_017030457.1.
DR AlphaFoldDB; A5YM69; -.
DR BioGRID; 138643; 10.
DR IntAct; A5YM69; 6.
DR STRING; 9606.ENSP00000367355; -.
DR iPTMnet; A5YM69; -.
DR PhosphoSitePlus; A5YM69; -.
DR BioMuta; ARHGEF35; -.
DR EPD; A5YM69; -.
DR jPOST; A5YM69; -.
DR MassIVE; A5YM69; -.
DR MaxQB; A5YM69; -.
DR PaxDb; A5YM69; -.
DR PeptideAtlas; A5YM69; -.
DR PRIDE; A5YM69; -.
DR ProteomicsDB; 763; -.
DR Antibodypedia; 67814; 60 antibodies from 12 providers.
DR DNASU; 445328; -.
DR Ensembl; ENST00000378115.3; ENSP00000367355.3; ENSG00000213214.6.
DR Ensembl; ENST00000688754.1; ENSP00000510684.1; ENSG00000213214.6.
DR GeneID; 445328; -.
DR KEGG; hsa:445328; -.
DR MANE-Select; ENST00000378115.3; ENSP00000367355.3; NM_001003702.3; NP_001003702.2.
DR UCSC; uc003wdz.3; human.
DR CTD; 445328; -.
DR GeneCards; ARHGEF35; -.
DR HGNC; HGNC:33846; ARHGEF35.
DR HPA; ENSG00000213214; Low tissue specificity.
DR neXtProt; NX_A5YM69; -.
DR OpenTargets; ENSG00000213214; -.
DR PharmGKB; PA165617645; -.
DR VEuPathDB; HostDB:ENSG00000213214; -.
DR eggNOG; KOG3523; Eukaryota.
DR GeneTree; ENSGT01030000234571; -.
DR HOGENOM; CLU_570570_0_0_1; -.
DR InParanoid; A5YM69; -.
DR OMA; CDTPEDW; -.
DR OrthoDB; 1176939at2759; -.
DR PhylomeDB; A5YM69; -.
DR PathwayCommons; A5YM69; -.
DR Reactome; R-HSA-193648; NRAGE signals death through JNK.
DR Reactome; R-HSA-416482; G alpha (12/13) signalling events.
DR SignaLink; A5YM69; -.
DR BioGRID-ORCS; 445328; 57 hits in 981 CRISPR screens.
DR ChiTaRS; ARHGEF35; human.
DR GenomeRNAi; 445328; -.
DR Pharos; A5YM69; Tdark.
DR PRO; PR:A5YM69; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; A5YM69; protein.
DR Bgee; ENSG00000213214; Expressed in mucosa of transverse colon and 96 other tissues.
DR InterPro; IPR029212; ARHGEF5/35_N.
DR Pfam; PF15441; ARHGEF5_35; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..484
FT /note="Rho guanine nucleotide exchange factor 35"
FT /id="PRO_0000348462"
FT REGION 139..418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..373
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..404
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 184
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT CONFLICT 8
FT /note="H -> R (in Ref. 2; BAC86243)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 484 AA; 53287 MW; B495D13224E9E52C CRC64;
MEAEEAQHGA SPPISAIEEF SIIPEAPMRS SQVSALGLEA QEDEDPSYKW REEHRLSATQ
QSELRDVCDY AIETMPSFPK EGSADVEPNQ ESLVAEACDT PEHWEAVPQS LAGRQARTLA
PPELWACPIQ SEHLDMAPFS SDLGSEEEEV EFWPGLTSLT LGSGQAEEEE ETSSDNSGQT
RYYSPCEEHP AETNQNEGAE SGTIRQGEEL PSEELQESQG LLHPQEVQVL EEQGQQEAGF
RGEGTLREDV CADGLLGEEQ MIEQVNDEKG EQKQKQEQVQ DVMLGRQGER MGLTGEPEGL
NDGEWEQEDM ERKAQGQGGP EQGEERKREL QVPEENRADS QDEKSQTFLG KSEEVTGKQE
DHGIKEKGVP VSGQEAKEPE SWDGGRLGAV GRARSREEEN EHHGPSMPAL IAPEDSPHCD
LFPGASYLVT QIPGTQTESR AEELSPAALS PLLEPIRCSH QPISLLGSFL TEESPDKEKL
LSVL
