ID   ARG39_BOVIN             Reviewed;         335 AA.
AC   Q0P5E3; Q0V8A2;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Rho guanine nucleotide exchange factor 39;
GN   Name=ARHGEF39;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-335.
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Promotes cell proliferation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}.
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DR   EMBL; BC120169; AAI20170.1; -; mRNA.
DR   EMBL; BT026317; ABG81473.1; -; mRNA.
DR   RefSeq; NP_001073268.1; NM_001079800.1.
DR   AlphaFoldDB; Q0P5E3; -.
DR   SMR; Q0P5E3; -.
DR   STRING; 9913.ENSBTAP00000015167; -.
DR   PaxDb; Q0P5E3; -.
DR   PRIDE; Q0P5E3; -.
DR   Ensembl; ENSBTAT00000015167; ENSBTAP00000015167; ENSBTAG00000011416.
DR   GeneID; 780881; -.
DR   KEGG; bta:780881; -.
DR   CTD; 84904; -.
DR   VEuPathDB; HostDB:ENSBTAG00000011416; -.
DR   VGNC; VGNC:26117; ARHGEF39.
DR   eggNOG; ENOG502QTR5; Eukaryota.
DR   GeneTree; ENSGT00440000033863; -.
DR   HOGENOM; CLU_052525_0_0_1; -.
DR   InParanoid; Q0P5E3; -.
DR   OMA; LLMCTDQ; -.
DR   OrthoDB; 711970at2759; -.
DR   TreeFam; TF350447; -.
DR   Reactome; R-BTA-416482; G alpha (12/13) signalling events.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000011416; Expressed in abomasum and 106 other tissues.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR   Gene3D; 1.20.900.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR042987; ARHGEF39.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR47056; PTHR47056; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Guanine-nucleotide releasing factor; Membrane;
KW   Reference proteome.
FT   CHAIN           1..335
FT                   /note="Rho guanine nucleotide exchange factor 39"
FT                   /id="PRO_0000291863"
FT   DOMAIN          22..197
FT                   /note="DH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT   DOMAIN          227..331
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
SQ   SEQUENCE   335 AA;  38282 MW;  98FA8950C4F81C61 CRC64;
     MESPAPGARC PVQEQRARWE RKRACTAREL LETERRYQEQ LGLVATYFVA ILRAKGTLRP
     PERQALFGPW ELIYGASQEL LPYLEGGRWG QGLEGFCNHL ELYTQFAANV ERSRTILQEQ
     LKKNKHFRRF VRLQEGRPEF GGLQLQDLLP LPLQRLQQYE NLAVALAENT GPNSPEHKQL
     TRAAQLISET AQRVHTIGQK QKNEQHLQRI QALLSGRQAK GLISGRWFLR QGWLLVVPPR
     GEPRPRMFFL FSDALLMAKP RPPLHLLQSG TFACRALYPM GECQLHRVFG HSGGPCGGLL
     SLSFPHEKLL LMSTDQEELS HWYHSLTLAI SSQKN