ARG39_MOUSE
ID ARG39_MOUSE Reviewed; 344 AA.
AC Q66JY6; A2AIN0; Q3TQV6;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Rho guanine nucleotide exchange factor 39;
GN Name=Arhgef39;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Promotes cell proliferation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q66JY6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q66JY6-2; Sequence=VSP_026287;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK163287; BAE37276.1; -; mRNA.
DR EMBL; AL732506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC080700; AAH80700.1; -; mRNA.
DR CCDS; CCDS18098.1; -. [Q66JY6-1]
DR RefSeq; NP_001013395.2; NM_001013377.2. [Q66JY6-1]
DR RefSeq; XP_006537893.1; XM_006537830.3.
DR AlphaFoldDB; Q66JY6; -.
DR SMR; Q66JY6; -.
DR IntAct; Q66JY6; 1.
DR STRING; 10090.ENSMUSP00000055293; -.
DR iPTMnet; Q66JY6; -.
DR PhosphoSitePlus; Q66JY6; -.
DR EPD; Q66JY6; -.
DR PaxDb; Q66JY6; -.
DR PeptideAtlas; Q66JY6; -.
DR PRIDE; Q66JY6; -.
DR ProteomicsDB; 283260; -. [Q66JY6-1]
DR Antibodypedia; 25913; 88 antibodies from 18 providers.
DR Ensembl; ENSMUST00000054538; ENSMUSP00000055293; ENSMUSG00000051517. [Q66JY6-1]
DR GeneID; 230098; -.
DR KEGG; mmu:230098; -.
DR UCSC; uc008spz.2; mouse. [Q66JY6-1]
DR CTD; 84904; -.
DR MGI; MGI:3036286; Arhgef39.
DR VEuPathDB; HostDB:ENSMUSG00000051517; -.
DR eggNOG; ENOG502QTR5; Eukaryota.
DR GeneTree; ENSGT00440000033863; -.
DR HOGENOM; CLU_052525_0_0_1; -.
DR InParanoid; Q66JY6; -.
DR OMA; LLMCTDQ; -.
DR OrthoDB; 711970at2759; -.
DR PhylomeDB; Q66JY6; -.
DR TreeFam; TF350447; -.
DR Reactome; R-MMU-193648; NRAGE signals death through JNK.
DR Reactome; R-MMU-416482; G alpha (12/13) signalling events.
DR Reactome; R-MMU-9013149; RAC1 GTPase cycle.
DR BioGRID-ORCS; 230098; 3 hits in 76 CRISPR screens.
DR ChiTaRS; Arhgef39; mouse.
DR PRO; PR:Q66JY6; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q66JY6; protein.
DR Bgee; ENSMUSG00000051517; Expressed in animal zygote and 139 other tissues.
DR ExpressionAtlas; Q66JY6; baseline and differential.
DR Genevisible; Q66JY6; MM.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR Gene3D; 1.20.900.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR042987; ARHGEF39.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR47056; PTHR47056; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; SSF48065; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Guanine-nucleotide releasing factor;
KW Membrane; Reference proteome.
FT CHAIN 1..344
FT /note="Rho guanine nucleotide exchange factor 39"
FT /id="PRO_0000291865"
FT DOMAIN 22..197
FT /note="DH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT DOMAIN 227..331
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT VAR_SEQ 1..246
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026287"
FT CONFLICT 60
FT /note="P -> L (in Ref. 3; AAH80700)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 344 AA; 39106 MW; F76359D01A61FB4A CRC64;
MESSGSAACC PVLQQRARWE RKRVCTAREL LETERRYQEQ LGLVATYFLR ILKAKGTLRP
PELQTLFGTW ELIYAASLEL LPYLEEGQWG LGLQGFCPHL ELYAQFAANA ERSQTTLQAQ
LKKNKRFRRF VKLQEGRPEF RGLQLQDLLP LPLQRLQQYE NLVVALAENT VPNSPDYQQL
TRAARLVSET AQKVHAIGQS QKNDQHLLRV QALLSGRKAK GLTSGRWFLR QGWLLVVPPT
GEPRPRMFFL FSDVLLMAKP RPPLHLLKSG TFVCRALYPM SQCHLSRVFG HSGGPCGGLL
SLSFPHEKLL LMSTDQEELS QWHHSLTLAI RSQKSSTHRS VTAT
