ID   ARGAL_BOVIN             Reviewed;        1237 AA.
AC   Q29RM4;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Rho guanine nucleotide exchange factor 10-like protein;
DE   AltName: Full=GrinchGEF;
GN   Name=ARHGEF10L; Synonyms=GRINCHGEF;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RHOA,
CC       RHOB and RHOC. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RHOA, RHOB and RHOC. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; BC114112; AAI14113.1; -; mRNA.
DR   RefSeq; NP_001039762.1; NM_001046297.1.
DR   AlphaFoldDB; Q29RM4; -.
DR   SMR; Q29RM4; -.
DR   STRING; 9913.ENSBTAP00000000909; -.
DR   PaxDb; Q29RM4; -.
DR   GeneID; 529043; -.
DR   KEGG; bta:529043; -.
DR   CTD; 55160; -.
DR   eggNOG; KOG3522; Eukaryota.
DR   InParanoid; Q29RM4; -.
DR   OrthoDB; 67600at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0051496; P:positive regulation of stress fiber assembly; IBA:GO_Central.
DR   GO; GO:0032933; P:SREBP signaling pathway; IBA:GO_Central.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   Gene3D; 2.130.10.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12877; PTHR12877; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Guanine-nucleotide releasing factor; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..1237
FT                   /note="Rho guanine nucleotide exchange factor 10-like
FT                   protein"
FT                   /id="PRO_0000342360"
FT   DOMAIN          276..463
FT                   /note="DH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT   REGION          1..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          132..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1091..1118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1142..1164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..45
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        148..164
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..196
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1091..1107
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         39
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HCE6"
FT   MOD_RES         132
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:A2AWP8"
FT   MOD_RES         153
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:A2AWP8"
FT   MOD_RES         241
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HCE6"
SQ   SEQUENCE   1237 AA;  135085 MW;  DBF9EE81E2C52255 CRC64;
     MASSSPLQAA AGDRLLPGGP GPSPEAEDDP GEGFEFDDSD DDEDTNAGPD VPRSALETEA
     DTPLIHLDSA PVIDLEPKPE PAQPQTQRPA AVSNGDAVDA AFSEVQRSGW RRKSSRRIER
     FTFPAVEEDV IYDDVPCENL DAQQPEAERN QPYEDARQDR APQEPEDLGW SSSEFESYSE
     DSGEEAKPEA EPTKHRVSFQ PKMTQLMKAA KSGTKDGLEK TRIAVMRKVS FLHRKDVLGD
     SEEEDMGLLE VSVSDIKPPA PELGPMPAGL TPQQVVRRHI LGSIVQSEGS YVDSLKRVLQ
     DYRNPLMEME PKALSARKCR AVFFRVKEIL HCHSMFQIAL SSRVAEWDST EKIGDLFVAS
     FSKSMVLDVY SDYVNNFTNA MSIIKKACLT KPAFLEFLKR RQVCSPDRVT LYGLMVKPIQ
     RFPQFILLLQ DMLKNTPRGH PDRLSLQLAL TELETLAEKL NEQKRLADQV AEIQQLTKSV
     SDRSSLNKLL TSGQRQLLLC ETLTETVYGD RGQLIKSKER RVFLLNDMLV CANINFKGQL
     EISSLAPLGP KYVVKWSTAL PQVQVVEVGQ EGGPYDKDNA LIQHAGAKKA SAAGQAQNKV
     YLGPPRLFQE LQDLQKDLAV VEQITLLVST LHGTYQNLNM TVAQDWCLAL QRLMRVKEEE
     IHSANKCRLR LLLPGKPDKS GRPISFMVVF ITPNPLSKIS WVNRLHLAKI GLREENQPGW
     LCPDEDKQSR APFWCPILAC CVPAFSFRGL SLQLGALVHS PVSCPLLGFS AVSTSLPQGY
     LWVGGGQEGA GGQVEIFSLN RPSPRTVKSF PLAAPVLCME YIPEPEEGDG RNGDKGCPAA
     DASAGVHPTI CLGLQDGSIL LYSSVDTGTQ CLAACRSPGL QPVLCLRHSP FHLLAGLQDG
     TLAAYPRTSG SVPWDLESPP MCLPVGPGPV RALLSLEEAV WASCGPRVTV LDATSLQTQQ
     SFEAHQDEAV SVTHMVKAGS GVWMAFSSGS SIRLFHTETL EHLQEINIAT RTTFLLPGQK
     HLCVTSLLIC QGLLWVGTDQ GVIVLLPVPR LEGIPKITGK GMVSLNGHCG PVAFLAVATS
     ILAPDILRSD QEEAEGQQAE EDKPDGPAPE PAPVPASHVG GELIRKKGIL LQYRLRSTSH
     LPGPLLSVRE PEPADGSALE HSEEDGSIYE MVDDPDVWVH NRPCARDAHR KEICSVAIIS
     GGRGYRNFGS AAGSPGKPAP CGETDSTLLI WQAPLTL