ARGAL_HUMAN
ID ARGAL_HUMAN Reviewed; 1279 AA.
AC Q9HCE6; B7ZKS1; Q17RW1; Q3YFJ4; Q5VXI5; Q5VXI6; Q66K51; Q6P0L7; Q8NAV5;
AC Q9NVT3;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-SEP-2018, sequence version 4.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Rho guanine nucleotide exchange factor 10-like protein;
DE AltName: Full=GrinchGEF;
GN Name=ARHGEF10L; Synonyms=GRINCHGEF, KIAA1626;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, INTERACTION WITH RHOA;
RP RHOB AND RHOC, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND VARIANT
RP VAL-1219.
RC TISSUE=Embryonic kidney;
RX PubMed=16112081; DOI=10.1016/j.bbrc.2005.08.025;
RA Winkler S., Mohl M., Wieland T., Lutz S.;
RT "GrinchGEF -- a novel Rho-specific guanine nucleotide exchange factor.";
RL Biochem. Biophys. Res. Commun. 335:1280-1286(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT VAL-1219.
RC TISSUE=Brain;
RX PubMed=10997877; DOI=10.1093/dnares/7.4.271;
RA Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVIII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:273-281(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 457-1279 (ISOFORM 5).
RC TISSUE=Mesangial cell, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND VARIANT
RP VAL-1219.
RC TISSUE=Colon, Eye, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40 AND SER-281, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [8]
RP VARIANT [LARGE SCALE ANALYSIS] VAL-96.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RHOA,
CC RHOB and RHOC. {ECO:0000269|PubMed:16112081}.
CC -!- SUBUNIT: Interacts with RHOA, RHOB and RHOC.
CC {ECO:0000269|PubMed:16112081}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16112081}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q9HCE6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9HCE6-2; Sequence=VSP_034421;
CC Name=3;
CC IsoId=Q9HCE6-3; Sequence=VSP_034421, VSP_034424;
CC Name=4;
CC IsoId=Q9HCE6-4; Sequence=VSP_034420, VSP_034422, VSP_034423,
CC VSP_034424;
CC Name=5;
CC IsoId=Q9HCE6-5; Sequence=VSP_034424, VSP_034425, VSP_034426;
CC -!- TISSUE SPECIFICITY: Detected in heart, liver, skeletal muscle, kidney
CC and pancreas. {ECO:0000269|PubMed:16112081}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91663.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB13452.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC03792.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQ139833; AAZ73162.1; -; mRNA.
DR EMBL; AB046846; BAB13452.1; ALT_INIT; mRNA.
DR EMBL; AK001383; BAA91663.1; ALT_INIT; mRNA.
DR EMBL; AK092020; BAC03792.1; ALT_SEQ; mRNA.
DR EMBL; AL139250; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL358593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC065561; AAH65561.1; -; mRNA.
DR EMBL; BC080596; AAH80596.1; -; mRNA.
DR EMBL; BC117171; AAI17172.1; -; mRNA.
DR EMBL; BC143347; AAI43348.1; -; mRNA.
DR CCDS; CCDS182.1; -. [Q9HCE6-1]
DR CCDS; CCDS30617.1; -. [Q9HCE6-2]
DR RefSeq; NP_001011722.2; NM_001011722.2. [Q9HCE6-2]
DR RefSeq; NP_001306766.1; NM_001319837.1. [Q9HCE6-3]
DR RefSeq; NP_001306767.1; NM_001319838.1. [Q9HCE6-4]
DR RefSeq; NP_001315053.1; NM_001328124.1.
DR RefSeq; NP_060595.3; NM_018125.3. [Q9HCE6-1]
DR RefSeq; XP_005245982.2; XM_005245925.2. [Q9HCE6-2]
DR RefSeq; XP_016857106.1; XM_017001617.1. [Q9HCE6-3]
DR RefSeq; XP_016857110.1; XM_017001621.1. [Q9HCE6-1]
DR AlphaFoldDB; Q9HCE6; -.
DR SMR; Q9HCE6; -.
DR BioGRID; 120461; 59.
DR IntAct; Q9HCE6; 12.
DR STRING; 9606.ENSP00000355060; -.
DR iPTMnet; Q9HCE6; -.
DR PhosphoSitePlus; Q9HCE6; -.
DR BioMuta; ARHGEF10L; -.
DR DMDM; 317373481; -.
DR EPD; Q9HCE6; -.
DR jPOST; Q9HCE6; -.
DR MassIVE; Q9HCE6; -.
DR PaxDb; Q9HCE6; -.
DR PeptideAtlas; Q9HCE6; -.
DR PRIDE; Q9HCE6; -.
DR ProteomicsDB; 81688; -. [Q9HCE6-1]
DR ProteomicsDB; 81689; -. [Q9HCE6-2]
DR ProteomicsDB; 81690; -. [Q9HCE6-3]
DR ProteomicsDB; 81691; -. [Q9HCE6-4]
DR ProteomicsDB; 81692; -. [Q9HCE6-5]
DR Antibodypedia; 29390; 44 antibodies from 12 providers.
DR DNASU; 55160; -.
DR Ensembl; ENST00000361221.8; ENSP00000355060.3; ENSG00000074964.17. [Q9HCE6-1]
DR Ensembl; ENST00000375415.5; ENSP00000364564.1; ENSG00000074964.17. [Q9HCE6-2]
DR GeneID; 55160; -.
DR KEGG; hsa:55160; -.
DR MANE-Select; ENST00000361221.8; ENSP00000355060.3; NM_018125.4; NP_060595.3.
DR UCSC; uc001ban.4; human. [Q9HCE6-1]
DR CTD; 55160; -.
DR DisGeNET; 55160; -.
DR GeneCards; ARHGEF10L; -.
DR HGNC; HGNC:25540; ARHGEF10L.
DR HPA; ENSG00000074964; Tissue enhanced (liver).
DR MIM; 612494; gene.
DR neXtProt; NX_Q9HCE6; -.
DR OpenTargets; ENSG00000074964; -.
DR PharmGKB; PA142672586; -.
DR VEuPathDB; HostDB:ENSG00000074964; -.
DR eggNOG; KOG3522; Eukaryota.
DR GeneTree; ENSGT00940000153798; -.
DR HOGENOM; CLU_001213_1_0_1; -.
DR InParanoid; Q9HCE6; -.
DR OMA; HKCDCKM; -.
DR OrthoDB; 67600at2759; -.
DR PhylomeDB; Q9HCE6; -.
DR TreeFam; TF331430; -.
DR PathwayCommons; Q9HCE6; -.
DR Reactome; R-HSA-193648; NRAGE signals death through JNK.
DR Reactome; R-HSA-416482; G alpha (12/13) signalling events.
DR Reactome; R-HSA-8980692; RHOA GTPase cycle.
DR Reactome; R-HSA-9013026; RHOB GTPase cycle.
DR Reactome; R-HSA-9013106; RHOC GTPase cycle.
DR SignaLink; Q9HCE6; -.
DR BioGRID-ORCS; 55160; 10 hits in 1068 CRISPR screens.
DR ChiTaRS; ARHGEF10L; human.
DR GenomeRNAi; 55160; -.
DR Pharos; Q9HCE6; Tbio.
DR PRO; PR:Q9HCE6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9HCE6; protein.
DR Bgee; ENSG00000074964; Expressed in cerebellar hemisphere and 197 other tissues.
DR ExpressionAtlas; Q9HCE6; baseline and differential.
DR Genevisible; Q9HCE6; HS.
DR GO; GO:0005829; C:cytosol; IDA:HGNC-UCL.
DR GO; GO:0005096; F:GTPase activator activity; IDA:HGNC-UCL.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:Reactome.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0051496; P:positive regulation of stress fiber assembly; IDA:HGNC-UCL.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
DR GO; GO:0032933; P:SREBP signaling pathway; IDA:HGNC-UCL.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; -; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; PTHR12877; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; SSF48065; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Guanine-nucleotide releasing factor;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..1279
FT /note="Rho guanine nucleotide exchange factor 10-like
FT protein"
FT /id="PRO_0000342361"
FT DOMAIN 316..503
FT /note="DH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1135..1163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1186..1208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..46
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 40
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 131
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:A2AWP8"
FT MOD_RES 152
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:A2AWP8"
FT MOD_RES 281
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT VAR_SEQ 1..221
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034420"
FT VAR_SEQ 203..241
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16112081"
FT /id="VSP_034421"
FT VAR_SEQ 222..278
FT /note="ILALRVGGRDMQELKHKYDCKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLH
FT RKDVL -> MLPSSSWGKRKLRGRLGWVRSDARGVMWARQEGLHHPHPHAVIRCPSSSS
FT SSVSCS (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034422"
FT VAR_SEQ 401..470
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034423"
FT VAR_SEQ 578..582
FT /note="Missing (in isoform 3, isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:16112081"
FT /id="VSP_034424"
FT VAR_SEQ 1062..1072
FT /note="GQKHLCVTSLL -> DRSLIKCSPRA (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034425"
FT VAR_SEQ 1073..1279
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_034426"
FT VARIANT 47
FT /note="S -> N (in dbSNP:rs34417109)"
FT /id="VAR_061794"
FT VARIANT 69
FT /note="D -> N (in dbSNP:rs35497285)"
FT /id="VAR_044183"
FT VARIANT 96
FT /note="A -> V (in a colorectal cancer sample; somatic
FT mutation; dbSNP:rs1421731181)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_044184"
FT VARIANT 991
FT /note="R -> W (in dbSNP:rs6695710)"
FT /id="VAR_044185"
FT VARIANT 1219
FT /note="I -> V (in dbSNP:rs2270976)"
FT /evidence="ECO:0000269|PubMed:10997877,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:16112081"
FT /id="VAR_044186"
FT CONFLICT 24
FT /note="S -> P (in Ref. 1; AAZ73162)"
FT /evidence="ECO:0000305"
FT CONFLICT 924
FT /note="L -> P (in Ref. 3; BAA91663)"
FT /evidence="ECO:0000305"
FT CONFLICT 1006
FT /note="F -> S (in Ref. 3; BAA91663)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1279 AA; 140379 MW; 1ED000F0C8864CD7 CRC64;
MASSNPPPQP AIGDQLVPGV PGPSSEAEDD PGEAFEFDDS DDEEDTSAAL GVPSLAPERD
TDPPLIHLDS IPVTDPDPAA APPGTGVPAW VSNGDAADAA FSGARHSSWK RKSSRRIDRF
TFPALEEDVI YDDVPCESPD AHQPGAERNL LYEDAHRAGA PRQAEDLGWS SSEFESYSED
SGEEAKPEVE VEPAKHRVSF QPKLSPDLTR LKERYARTKR DILALRVGGR DMQELKHKYD
CKMTQLMKAA KSGTKDGLEK TRMAVMRKVS FLHRKDVLGD SEEEDMGLLE VSVSDIKPPA
PELGPMPEGL SPQQVVRRHI LGSIVQSEGS YVESLKRILQ DYRNPLMEME PKALSARKCQ
VVFFRVKEIL HCHSMFQIAL SSRVAEWDST EKIGDLFVAS FSKSMVLDVY SDYVNNFTSA
MSIIKKACLT KPAFLEFLKR RQVCSPDRVT LYGLMVKPIQ RFPQFILLLQ DMLKNTPRGH
PDRLSLQLAL TELETLAEKL NEQKRLADQV AEIQQLTKSV SDRSSLNKLL TSGQRQLLLC
ETLTETVYGD RGQLIKSKER RVFLLNDMLV CANINFKPAN HRGQLEISSL VPLGPKYVVK
WNTALPQVQV VEVGQDGGTY DKDNVLIQHS GAKKASASGQ AQNKVYLGPP RLFQELQDLQ
KDLAVVEQIT LLISTLHGTY QNLNMTVAQD WCLALQRLMR VKEEEIHSAN KCRLRLLLPG
KPDKSGRPIS FMVVFITPNP LSKISWVNRL HLAKIGLREE NQPGWLCPDE DKKSKAPFWC
PILACCIPAF SSRALSLQLG ALVHSPVNCP LLGFSAVSTS LPQGYLWVGG GQEGAGGQVE
IFSLNRPSPR TVKSFPLAAP VLCMEYIPEL EEEAESRDES PTVADPSATV HPTICLGLQD
GSILLYSSVD TGTQCLVSCR SPGLQPVLCL RHSPFHLLAG LQDGTLAAYP RTSGGVLWDL
ESPPVCLTVG PGPVRTLLSL EDAVWASCGP RVTVLEATTL QPQQSFEAHQ DEAVSVTHMV
KAGSGVWMAF SSGTSIRLFH TETLEHLQEI NIATRTTFLL PGQKHLCVTS LLICQGLLWV
GTDQGVIVLL PVPRLEGIPK ITGKGMVSLN GHCGPVAFLA VATSILAPDI LRSDQEEAEG
PRAEEDKPDG QAHEPMPDSH VGRELTRKKG ILLQYRLRST AHLPGPLLSM REPAPADGAA
LEHSEEDGSI YEMADDPDIW VRSRPCARDA HRKEICSVAI ISGGQGYRNF GSALGSSGRQ
APCGETDSTL LIWQVPLML
