ID   ARGAL_PONAB             Reviewed;        1233 AA.
AC   Q5R5M3;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Rho guanine nucleotide exchange factor 10-like protein;
DE   AltName: Full=GrinchGEF;
GN   Name=ARHGEF10L; Synonyms=GRINCHGEF;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RHOA,
CC       RHOB and RHOC. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RHOA, RHOB and RHOC. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; CR860834; CAH92943.1; -; mRNA.
DR   RefSeq; NP_001127607.1; NM_001134135.1.
DR   AlphaFoldDB; Q5R5M3; -.
DR   SMR; Q5R5M3; -.
DR   STRING; 9601.ENSPPYP00000002097; -.
DR   GeneID; 100174686; -.
DR   KEGG; pon:100174686; -.
DR   CTD; 55160; -.
DR   eggNOG; KOG3522; Eukaryota.
DR   InParanoid; Q5R5M3; -.
DR   OrthoDB; 67600at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   Gene3D; 2.130.10.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12877; PTHR12877; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Guanine-nucleotide releasing factor; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..1233
FT                   /note="Rho guanine nucleotide exchange factor 10-like
FT                   protein"
FT                   /id="PRO_0000342363"
FT   DOMAIN          275..462
FT                   /note="DH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT   REGION          1..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          159..193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1089..1117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1140..1161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..46
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..193
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1089..1107
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         40
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HCE6"
FT   MOD_RES         131
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:A2AWP8"
FT   MOD_RES         152
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:A2AWP8"
FT   MOD_RES         240
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HCE6"
SQ   SEQUENCE   1233 AA;  134775 MW;  57E3DEE1C75838C2 CRC64;
     MASSNPPPQP AIGDQLVPGA PGPSSEAEDD PGEAFEFDDS DDEEDTSAAL GVPSLAPERD
     TDPPLIHLDS IPVTDPDPAA APPGTGVPAW VSNGDAADAA FSGARHSSWK RKSSRRIDRF
     TFPALEEDVI YDDVPCESPD AHQPGAERNL LYEDAHRAGA PRQAEDLGWS SSEFESYSED
     SGEEAKPEVE PAKHRVSFQP KMTQLMKAAK SGTKDGLEKT RMAVMRKVSF LHRKDVLGDS
     EEEDMGLLEV SVSDIKPPAP ELGPMPEGLS PQQVVRRHIL GSIVQSEGSY VESLKRILQD
     YRNPLMEMEP KALSARKCQV VFFRVKEILH CHSMFQIALS SRVAEWDSTE KIGDLFVASF
     SKSMVLDVYS DYVNNFTGAM SIIKKACLTK PAFLEFLKRR QVCSSDRVTL YGLMVKPIQR
     FPQFILLLQD MLKNTPRGHP DRLSLQLALT ELETLAEKLN EQKRLADQVA EIQQLTKSVS
     DRSSLNKLLT SGQRQLLLCE TLTETVYGDR GQLIKSKERR VFLLNDMLVC ANINFKGQLE
     ISSLVPLGPK YVVKWNTALP QVQVVEVGQD GGTYDKDNVL IQHSGAKKAS ASGQAQNKVY
     LGPPRLFQEL QDLQKDLAVV EQITLLISTL HGTYQNLNMT VAQDWCLALQ RLMRVKEEEI
     HSANKCRLRL LLPGKPDKSG RPTSFMVVFI TPNPLSKISW VNRLHLAKIG LREENQPGWL
     CPDEDKKSKA PFWCPILACC IPAFSSRALS LQLGALVHSP VNCPLLGFSA VSTSLPQGYL
     WVGGGQEGAG GQVEIFSLNR PSPRTVKSFP LAAPVLCMEY IPELEEEAES RDESPTAADP
     SATVHPTICL GLQDGSILLY GSVDTGTQCL ASCRSPGLQP VLCLRHSPFY LLAGLQDGTL
     AAYPRTSGGV LWDLESPPVC LTVGPGPVRT LLSLEDAVWA SCGPRVTVLE ATTLQPQQSF
     EAHQDEAVSV THMVKAGSGV WMAFSSGTSI RLFHTETLEH LQEINIATRT TFLLPGQKHL
     CVTSLLICQG LLWVGTDQGV IVLLPVPRLE GIPKITGKGM VSLNGHCGPV AFLAVAISIL
     APDILRSDQE EAEGPRAEEE KPDGQAHQPM PDSHVGRELT RKKGILLQYR LRSTAHLPGP
     LLSMREPAPA DGAALEHSEE DGSIYEMADD PDVWVRSRPC ARDAHRKEIC SVAIISGGQG
     YRNFGSALGS SGRLAPCGET DSTLLIWQVP LML