ID   ARGA_VIBVU              Reviewed;         445 AA.
AC   P59294;
DT   12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   12-FEB-2003, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Amino-acid acetyltransferase;
DE            EC=2.3.1.1;
DE   AltName: Full=N-acetylglutamate synthase;
DE            Short=AGS;
DE            Short=NAGS;
GN   Name=argA; OrderedLocusNames=VV1_1799;
OS   Vibrio vulnificus (strain CMCP6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=216895;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CMCP6;
RA   Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.;
RT   "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate;
CC         Xref=Rhea:RHEA:24292, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985,
CC         ChEBI:CHEBI:44337, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.1;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-
CC       L-ornithine from L-glutamate: step 1/4.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the acetyltransferase family. ArgA subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE016795; AAO10207.1; -; Genomic_DNA.
DR   RefSeq; WP_011079707.1; NC_004459.3.
DR   AlphaFoldDB; P59294; -.
DR   SMR; P59294; -.
DR   EnsemblBacteria; AAO10207; AAO10207; VV1_1799.
DR   KEGG; vvu:VV1_1799; -.
DR   HOGENOM; CLU_024773_0_0_6; -.
DR   OMA; KRKYNWD; -.
DR   UniPathway; UPA00068; UER00106.
DR   Proteomes; UP000002275; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004042; F:acetyl-CoA:L-glutamate N-acetyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0103045; F:methione N-acyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04237; AAK_NAGS-ABP; 1.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   HAMAP; MF_01105; N_acetyl_glu_synth; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR000182; GNAT_dom.
DR   InterPro; IPR033719; NAGS_kin.
DR   InterPro; IPR010167; NH2A_AcTrfase.
DR   PANTHER; PTHR30602; PTHR30602; 2.
DR   Pfam; PF00696; AA_kinase; 1.
DR   Pfam; PF00583; Acetyltransf_1; 1.
DR   PIRSF; PIRSF000423; ArgA; 1.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   TIGRFAMs; TIGR01890; N-Ac-Glu-synth; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm;
KW   Transferase.
FT   CHAIN           1..445
FT                   /note="Amino-acid acetyltransferase"
FT                   /id="PRO_0000186810"
FT   DOMAIN          299..438
FT                   /note="N-acetyltransferase"
SQ   SEQUENCE   445 AA;  49033 MW;  AA9638D7FC647E2B CRC64;
     MKIRSTALVK GFRQSTPYVN AHRGKTMVIL LGGEAIADKN FSNIINDIAL MHSLGVKVVL
     VYGARPQINQ LLDKQSSQTP YHKHIRVTDE NSLSIVMQAA GQLQLAITAS LSMSLNNTPM
     AGTHLNVVSG NFVIAQPLGI DEGVDYCHSG RIRRIDTEAI NRSLDQGSIV LLGPIASSVT
     GECFNLLSEE VATQVAIKLK ADKLIGFCSE QGVIDEEGNA VAELFPSDAE KFIQKLSVDV
     DPDSDFHSGT LRFLKGAVAA CRAGVPRSHL ISYKIDGALI QELFSFDGIG TQVVMASAEQ
     VRQACIDDIG GILELIRPLE EQGILVRRSR EQLEQEVERF TIIEKDGLII GCAALYPYID
     EHMAEMACVA IHPDYRDGNR GLLLLNYMKH RSKSIGIEQI FVLTTHSVHW FREQGFYEIG
     VDSLPMAKKS LYNYQRRSKI LALPL