ARGA_YERPE
ID ARGA_YERPE Reviewed; 441 AA.
AC Q8ZH86; Q0WI22;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 129.
DE RecName: Full=Amino-acid acetyltransferase;
DE EC=2.3.1.1;
DE AltName: Full=N-acetylglutamate synthase;
DE Short=AGS;
DE Short=NAGS;
GN Name=argA; OrderedLocusNames=YPO1022, y3162, YP_2828;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate;
CC Xref=Rhea:RHEA:24292, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:44337, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.1;
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-
CC L-ornithine from L-glutamate: step 1/4.
CC -!- SUBUNIT: Homohexamer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the acetyltransferase family. ArgA subfamily.
CC {ECO:0000305}.
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DR EMBL; AL590842; CAL19688.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM86712.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS63012.1; -; Genomic_DNA.
DR PIR; AF0125; AF0125.
DR RefSeq; WP_002211624.1; NZ_WHLN01000012.1.
DR RefSeq; YP_002346066.1; NC_003143.1.
DR AlphaFoldDB; Q8ZH86; -.
DR SMR; Q8ZH86; -.
DR STRING; 214092.YPO1022; -.
DR PaxDb; Q8ZH86; -.
DR DNASU; 1148109; -.
DR EnsemblBacteria; AAM86712; AAM86712; y3162.
DR EnsemblBacteria; AAS63012; AAS63012; YP_2828.
DR GeneID; 66844544; -.
DR KEGG; ype:YPO1022; -.
DR KEGG; ypk:y3162; -.
DR KEGG; ypm:YP_2828; -.
DR PATRIC; fig|214092.21.peg.1310; -.
DR eggNOG; COG0548; Bacteria.
DR eggNOG; COG1246; Bacteria.
DR HOGENOM; CLU_024773_0_0_6; -.
DR OMA; KRKYNWD; -.
DR UniPathway; UPA00068; UER00106.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004042; F:acetyl-CoA:L-glutamate N-acetyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0103045; F:methione N-acyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd04237; AAK_NAGS-ABP; 1.
DR Gene3D; 3.40.1160.10; -; 1.
DR HAMAP; MF_01105; N_acetyl_glu_synth; 1.
DR InterPro; IPR036393; AceGlu_kinase-like_sf.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR InterPro; IPR000182; GNAT_dom.
DR InterPro; IPR033719; NAGS_kin.
DR InterPro; IPR010167; NH2A_AcTrfase.
DR PANTHER; PTHR30602; PTHR30602; 2.
DR Pfam; PF00696; AA_kinase; 1.
DR Pfam; PF00583; Acetyltransf_1; 1.
DR PIRSF; PIRSF000423; ArgA; 1.
DR SUPFAM; SSF53633; SSF53633; 1.
DR SUPFAM; SSF55729; SSF55729; 1.
DR TIGRFAMs; TIGR01890; N-Ac-Glu-synth; 1.
DR PROSITE; PS51186; GNAT; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm;
KW Reference proteome; Transferase.
FT CHAIN 1..441
FT /note="Amino-acid acetyltransferase"
FT /id="PRO_0000186812"
FT DOMAIN 295..434
FT /note="N-acetyltransferase"
FT CONFLICT 431..441
FT /note="QRRSKILLADL -> CNERCNSDPHPTPEIRSRG (in Ref. 3;
FT AAS63012)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 441 AA; 49355 MW; EBDC58CA73BC1960 CRC64;
MKERSTELVQ GFRHSVPYIN AHRGKTFVVM LGGEAIEHEN FSSIVNDIGL LHSLGIRLVV
VYGARPQIDS NLADHNYEPI YHKHTRVTDA RTLEMVKQAA GLLQLDITAR LSMSLNNTPL
QGAHINVVSG NFIIAQPLGV DDGVDYCHSG RIRRIDEEAI HRQLDNGAIV LLGPVAVSVT
GESFNLTSEE VATQLAIKLK AEKMIGFCSS QGVTDSEGNI ISELFPNDAQ KRIEDLEQDG
DYNSGTVRFL RGAVKACRSG VRRSHLLSYQ EDGALIQELF SRDGIGTQIV MESAEQVRRA
TINDIGGILE LIRPLEQQGI LVRRSREQLE MEIDKFTIIE RDNLTIACAA LYPFPDEHIG
EMACVAVHPD YRSSSRGEML LNRITNQARQ MGLKKLFVLT TRSIHWFQER GFTPAEVDVL
PIQKQELYNY QRRSKILLAD L
