ID   LEUE_ECO24              Reviewed;         212 AA.
AC   A7ZMR9;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Leucine efflux protein;
GN   Name=leuE; OrderedLocusNames=EcE24377A_2024;
OS   Escherichia coli O139:H28 (strain E24377A / ETEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=331111;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E24377A / ETEC;
RX   PubMed=18676672; DOI=10.1128/jb.00619-08;
RA   Rasko D.A., Rosovitz M.J., Myers G.S.A., Mongodin E.F., Fricke W.F.,
RA   Gajer P., Crabtree J., Sebaihia M., Thomson N.R., Chaudhuri R.,
RA   Henderson I.R., Sperandio V., Ravel J.;
RT   "The pangenome structure of Escherichia coli: comparative genomic analysis
RT   of E. coli commensal and pathogenic isolates.";
RL   J. Bacteriol. 190:6881-6893(2008).
CC   -!- FUNCTION: Exporter of leucine. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Rht family. {ECO:0000305}.
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DR   EMBL; CP000800; ABV17098.1; -; Genomic_DNA.
DR   RefSeq; WP_000457202.1; NC_009801.1.
DR   AlphaFoldDB; A7ZMR9; -.
DR   EnsemblBacteria; ABV17098; ABV17098; EcE24377A_2024.
DR   GeneID; 66674313; -.
DR   KEGG; ecw:EcE24377A_2024; -.
DR   HOGENOM; CLU_079569_3_1_6; -.
DR   OMA; AGVWCGD; -.
DR   Proteomes; UP000001122; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001123; LeuE-type.
DR   PANTHER; PTHR30086; PTHR30086; 1.
DR   Pfam; PF01810; LysE; 1.
DR   PIRSF; PIRSF006324; LeuE; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..212
FT                   /note="Leucine efflux protein"
FT                   /id="PRO_0000316799"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   212 AA;  23258 MW;  0F56BABA635815A0 CRC64;
     MFAEYGVLNY WTYLVGAIFI VLVPGPNTLF VLKNSVSSGM KGGYLAACGV FIGDAVLMFL
     AWAGVATLIK TTPILFNIVR YLGAFYLLYL GSKILYATLK GKNNEAKSDE PQYGAIFKRA
     LILSLTNPKA ILFYVSFFVQ FIDVNAPHTG ISFFILATTL ELVSFCYLSF LIISGAFVTQ
     YIRTKKKLAK VGNSLIGLMF VGFAARLATL QS