LEUE_ECOL5
ID LEUE_ECOL5 Reviewed; 212 AA.
AC Q0TH31;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Leucine efflux protein;
GN Name=leuE; OrderedLocusNames=ECP_1745;
OS Escherichia coli O6:K15:H31 (strain 536 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=362663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=536 / UPEC;
RX PubMed=16879640; DOI=10.1111/j.1365-2958.2006.05255.x;
RA Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U.,
RA Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.;
RT "Role of pathogenicity island-associated integrases in the genome
RT plasticity of uropathogenic Escherichia coli strain 536.";
RL Mol. Microbiol. 61:584-595(2006).
CC -!- FUNCTION: Exporter of leucine. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Rht family. {ECO:0000305}.
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DR EMBL; CP000247; ABG69748.1; -; Genomic_DNA.
DR RefSeq; WP_000457211.1; NC_008253.1.
DR AlphaFoldDB; Q0TH31; -.
DR STRING; 362663.ECP_1745; -.
DR PRIDE; Q0TH31; -.
DR EnsemblBacteria; ABG69748; ABG69748; ECP_1745.
DR KEGG; ecp:ECP_1745; -.
DR HOGENOM; CLU_079569_3_1_6; -.
DR OMA; AGVWCGD; -.
DR Proteomes; UP000009182; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR InterPro; IPR001123; LeuE-type.
DR PANTHER; PTHR30086; PTHR30086; 1.
DR Pfam; PF01810; LysE; 1.
DR PIRSF; PIRSF006324; LeuE; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..212
FT /note="Leucine efflux protein"
FT /id="PRO_0000316803"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 212 AA; 23261 MW; 2E91B9E248C9B72A CRC64;
MFAEYGVLNY WTYLVGAIFI VLVPGPNTLF VLKNSVSSGM KGGYLAACGV FIGDAVLMFL
AWAGVATLIK TTPILFNIVR YLGAFYLLYL GSKILYATLK GKNSETKSDE PQYGAIFKRA
LILSLTNPKA ILFYVSFFVQ FIDVNAPHTG ISFFILATTL ELVSFCYLSF LIISGAFVTQ
YIRTKKKLAK VGNSLIGLMF VGFAARLATL QS