ID   LEUE_KLEP7              Reviewed;         212 AA.
AC   A6T7N0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Leucine efflux protein;
GN   Name=leuE; OrderedLocusNames=KPN78578_11400; ORFNames=KPN_01168;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Exporter of leucine. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Rht family. {ECO:0000305}.
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DR   EMBL; CP000647; ABR76601.1; -; Genomic_DNA.
DR   RefSeq; WP_004150783.1; NC_009648.1.
DR   AlphaFoldDB; A6T7N0; -.
DR   STRING; 272620.KPN_01168; -.
DR   EnsemblBacteria; ABR76601; ABR76601; KPN_01168.
DR   KEGG; kpn:KPN_01168; -.
DR   HOGENOM; CLU_079569_3_1_6; -.
DR   OMA; AGVWCGD; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR001123; LeuE-type.
DR   PANTHER; PTHR30086; PTHR30086; 1.
DR   Pfam; PF01810; LysE; 1.
DR   PIRSF; PIRSF006324; LeuE; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..212
FT                   /note="Leucine efflux protein"
FT                   /id="PRO_0000316805"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   212 AA;  22950 MW;  555DB616850882A3 CRC64;
     MFAEFGVLNY LTYLVGAVFI ILVPGPNTFF VLKTGIAHGV KKGYLAAAGV FIGDAVLMFL
     AFAGVATLIK TTPVLFNVVR YLGAIYLLWL GGKMLYAVLT QRDGQSDASA EPASAILKRS
     LTLSLTNPKA ILFYVSFFVQ FIDVNAKTPG VAFFILALTL EVISFCYMSF LILSGSFVTR
     YVKTRKKLAK LGNSLIGLVF VGFAARLATL QS