LEUNG_ARATH
ID LEUNG_ARATH Reviewed; 931 AA.
AC Q9FUY2; Q9SZY9;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 09-MAY-2003, sequence version 2.
DT 25-MAY-2022, entry version 157.
DE RecName: Full=Transcriptional corepressor LEUNIG {ECO:0000303|PubMed:11058164};
DE AltName: Full=Protein ROTUNDA2 {ECO:0000303|PubMed:15208345};
GN Name=LUG {ECO:0000303|PubMed:11058164};
GN Synonyms=RON2 {ECO:0000303|PubMed:15208345};
GN OrderedLocusNames=At4g32551 {ECO:0000312|Araport:AT4G32551};
GN ORFNames=L23H3.30 {ECO:0000312|EMBL:CAB43692.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=11058164; DOI=10.1073/pnas.230352397;
RA Conner J., Liu Z.;
RT "LEUNIG, a putative transcriptional corepressor that regulates AGAMOUS
RT expression during flower development.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12902-12907(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP FUNCTION.
RX PubMed=7743940; DOI=10.1242/dev.121.4.975;
RA Liu Z., Meyerowitz E.M.;
RT "LEUNIG regulates AGAMOUS expression in Arabidopsis flowers.";
RL Development 121:975-991(1995).
RN [5]
RP FUNCTION.
RX PubMed=11782418; DOI=10.1242/dev.129.1.253;
RA Franks R.G., Wang C., Levin J.Z., Liu Z.;
RT "SEUSS, a member of a novel family of plant regulatory proteins, represses
RT floral homeotic gene expression with LEUNIG.";
RL Development 129:253-263(2002).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX PubMed=15208345; DOI=10.1093/jxb/erh165;
RA Cnops G., Jover-Gil S., Peters J.L., Neyt P., De Block S., Robles P.,
RA Ponce M.R., Gerats T., Micol J.L., Van Lijsebettens M.;
RT "The rotunda2 mutants identify a role for the LEUNIG gene in vegetative
RT leaf morphogenesis.";
RL J. Exp. Bot. 55:1529-1539(2004).
RN [7]
RP FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, AND INTERACTION WITH
RP SEU.
RX PubMed=15277686; DOI=10.1073/pnas.0403055101;
RA Sridhar V.V., Surendrarao A., Gonzalez D., Conlan R.S., Liu Z.;
RT "Transcriptional repression of target genes by LEUNIG and SEUSS, two
RT interacting regulatory proteins for Arabidopsis flower development.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:11494-11499(2004).
RN [8]
RP INTERACTION WITH SEU; AGL24-AP1 AND SVP-AP1.
RX PubMed=16679456; DOI=10.1105/tpc.106.041798;
RA Gregis V., Sessa A., Colombo L., Kater M.M.;
RT "AGL24, SHORT VEGETATIVE PHASE, and APETALA1 redundantly control AGAMOUS
RT during early stages of flower development in Arabidopsis.";
RL Plant Cell 18:1373-1382(2006).
RN [9]
RP INTERACTION WITH HDA19; MED14 AND CDKE-1.
RX PubMed=17526732; DOI=10.1128/mcb.01912-06;
RA Gonzalez D., Bowen A.J., Carroll T.S., Conlan R.S.;
RT "The transcription corepressor LEUNIG interacts with the histone
RT deacetylase HDA19 and mediator components MED14 (SWP) and CDK8 (HEN3) to
RT repress transcription.";
RL Mol. Cell. Biol. 27:5306-5315(2007).
RN [10]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND INDUCTION BY BIOTIC
RP AND ABIOTIC STRESSES.
RX PubMed=18390806; DOI=10.1104/pp.108.115923;
RA Sitaraman J., Bui M., Liu Z.;
RT "LEUNIG_HOMOLOG and LEUNIG perform partially redundant functions during
RT Arabidopsis embryo and floral development.";
RL Plant Physiol. 147:672-681(2008).
RN [11]
RP FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH YAB3; YAB5 AND YAB1/FIL,
RP AND DEVELOPMENTAL STAGE.
RX PubMed=19837869; DOI=10.1105/tpc.109.070458;
RA Stahle M.I., Kuehlich J., Staron L., von Arnim A.G., Golz J.F.;
RT "YABBYs and the transcriptional corepressors LEUNIG and LEUNIG_HOMOLOG
RT maintain leaf polarity and meristem activity in Arabidopsis.";
RL Plant Cell 21:3105-3118(2009).
RN [12]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Columbia, and cv. Landsberg erecta;
RX PubMed=21362134; DOI=10.1111/j.1744-7909.2011.01036.x;
RA Bui M., Lim N., Sijacic P., Liu Z.;
RT "LEUNIG_HOMOLOG and LEUNIG regulate seed mucilage extrusion in
RT Arabidopsis.";
RL J. Integr. Plant Biol. 53:399-408(2011).
RN [13]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21402796; DOI=10.1104/pp.111.172692;
RA Walker M., Tehseen M., Doblin M.S., Pettolino F.A., Wilson S.M., Bacic A.,
RA Golz J.F.;
RT "The transcriptional regulator LEUNIG_HOMOLOG regulates mucilage release
RT from the Arabidopsis testa.";
RL Plant Physiol. 156:46-60(2011).
CC -!- FUNCTION: Transcription repressor subunit of the SEU-LUG
CC transcriptional corepressor of the C class floral homeotic gene AGAMOUS
CC during the early stages of floral meristem development. Is part of the
CC A class cadastral complex that define the boundaries between the A and
CC C class homeotic genes expression and function. Interacts together with
CC APETALA2 and SEUSS to repress AGAMOUS expression. Also plays a role in
CC ovule and pollen development (PubMed:11782418, PubMed:15277686,
CC PubMed:7743940). Implicated in embryo and floral development
CC (PubMed:18390806). Involved in post-synthesis cell wall modifications
CC necessary for mucilage extrusion from seeds upon imbibition, probably
CC by promoting the expression of genes required for mucilage maturation
CC (PubMed:21362134, PubMed:21402796). Involved in vegetative leaf
CC morphogenesis at later stages of leaf development by restricting cell
CC expansion during leaf growth (PubMed:15208345). Regulates the
CC maintenance on leaf polarity and meristem activity as well as the
CC initiation of embryonic shoot apical meristem (SAM) development
CC (PubMed:19837869). {ECO:0000269|PubMed:11782418,
CC ECO:0000269|PubMed:15208345, ECO:0000269|PubMed:15277686,
CC ECO:0000269|PubMed:18390806, ECO:0000269|PubMed:19837869,
CC ECO:0000269|PubMed:21362134, ECO:0000269|PubMed:21402796,
CC ECO:0000269|PubMed:7743940}.
CC -!- SUBUNIT: Forms a corepressor complex with SEU; LUG is the transcription
CC repressor subunit and SEU the specific DNA-binding adapter. Interacts
CC with AGL24-AP1 and SVP-AP1 dimers, and possibly with SEP3, especially
CC when complexed to SEU. Interacts with MED14, HDA19 and CDKE-1
CC (PubMed:15277686, PubMed:16679456, PubMed:17526732). Binds to YAB3,
CC YAB5 and YAB1/FIL; these complexes promote adaxial cell identity in
CC leaves as well as embryonic shoot apical meristem (SAM) initiation and
CC postembryonic SAM maintenance (PubMed:19837869).
CC {ECO:0000269|PubMed:15277686, ECO:0000269|PubMed:16679456,
CC ECO:0000269|PubMed:17526732, ECO:0000269|PubMed:19837869}.
CC -!- INTERACTION:
CC Q9FUY2; Q8W234: SEU; NbExp=6; IntAct=EBI-1771115, EBI-1771131;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15277686}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9FUY2-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed in young flower primordia, later becomes
CC localized to petals, stamens and carpels. Is also expressed in
CC vegetative tissues (PubMed:11058164). Expressed in roots, stems,
CC leaves, seedlings, apex, flowers, flower organs and seeds
CC (PubMed:18390806). {ECO:0000269|PubMed:11058164,
CC ECO:0000269|PubMed:18390806}.
CC -!- DEVELOPMENTAL STAGE: Expressed prominently during both female and male
CC gametes development (PubMed:11058164). Accumulates throughout young
CC developing leaves, before being confined to the vasculature of older
CC leaves (PubMed:19837869). {ECO:0000269|PubMed:11058164,
CC ECO:0000269|PubMed:19837869}.
CC -!- INDUCTION: Induced by exposures to biotic stress (e.g. Agrobacterium
CC tumefaciens) and abiotic stress (e.g. hypoxia, cycloheximide, 2,4-
CC dichlorophenoxyacetic acid, AgNO(3) and aminoethoxyvinylglycine).
CC Repressed by exposures to biotic stress (e.g. nematode and Botrytis
CC cinerea) and abiotic stress (e.g. salt, genotoxic, wounding, drought
CC and oxidative stress). {ECO:0000269|PubMed:18390806}.
CC -!- DISRUPTION PHENOTYPE: Slight defects in seed mucilage extrusion
CC (PubMed:21362134, PubMed:21402796). Ectopic expression of AGAMOUS,
CC leading to the replacement of sepals by carpels and stamens and of
CC petals by stamens (PubMed:15277686). Wide and serrated vegetative leaf
CC lamina, narrow cauline leaves, large palisade cells and reduced
CC fertility (PubMed:15208345). In plants lacking both LUG and LUH, embryo
CC lethality and abnormal flowers (PubMed:18390806). Enhance the polarity
CC and growth defects of fil yab3 and luh/+ lug mutant leaves, being
CC partially abaxialized (PubMed:19837869). {ECO:0000269|PubMed:15208345,
CC ECO:0000269|PubMed:15277686, ECO:0000269|PubMed:18390806,
CC ECO:0000269|PubMed:19837869, ECO:0000269|PubMed:21362134,
CC ECO:0000269|PubMed:21402796}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB43692.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB79972.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF277458; AAG32022.1; -; mRNA.
DR EMBL; AL050398; CAB43692.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161581; CAB79972.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE86076.1; -; Genomic_DNA.
DR PIR; T08588; T08588.
DR RefSeq; NP_567896.1; NM_119407.3. [Q9FUY2-1]
DR AlphaFoldDB; Q9FUY2; -.
DR SMR; Q9FUY2; -.
DR BioGRID; 14676; 2.
DR IntAct; Q9FUY2; 3.
DR STRING; 3702.AT4G32551.2; -.
DR iPTMnet; Q9FUY2; -.
DR MetOSite; Q9FUY2; -.
DR PaxDb; Q9FUY2; -.
DR PRIDE; Q9FUY2; -.
DR ProteomicsDB; 238602; -. [Q9FUY2-1]
DR EnsemblPlants; AT4G32551.1; AT4G32551.1; AT4G32551. [Q9FUY2-1]
DR GeneID; 829390; -.
DR Gramene; AT4G32551.1; AT4G32551.1; AT4G32551. [Q9FUY2-1]
DR KEGG; ath:AT4G32551; -.
DR Araport; AT4G32551; -.
DR eggNOG; KOG0266; Eukaryota.
DR HOGENOM; CLU_000288_57_28_1; -.
DR InParanoid; Q9FUY2; -.
DR OMA; ASMKQRF; -.
DR PhylomeDB; Q9FUY2; -.
DR PRO; PR:Q9FUY2; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9FUY2; baseline and differential.
DR Genevisible; Q9FUY2; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:UniProtKB.
DR GO; GO:0071217; P:cellular response to external biotic stimulus; IDA:UniProtKB.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0010393; P:galacturonan metabolic process; IMP:UniProtKB.
DR GO; GO:0010073; P:meristem maintenance; IMP:UniProtKB.
DR GO; GO:0080001; P:mucilage extrusion from seed coat; IMP:UniProtKB.
DR GO; GO:0048359; P:mucilage metabolic process involved in seed coat development; IMP:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0009944; P:polarity specification of adaxial/abaxial axis; IMP:UniProtKB.
DR GO; GO:0051512; P:positive regulation of unidimensional cell growth; IMP:UniProtKB.
DR GO; GO:0045995; P:regulation of embryonic development; IMP:UniProtKB.
DR GO; GO:0009909; P:regulation of flower development; IMP:UniProtKB.
DR GO; GO:2000024; P:regulation of leaf development; IMP:UniProtKB.
DR GO; GO:1902183; P:regulation of shoot apical meristem development; IMP:UniProtKB.
DR GO; GO:0009733; P:response to auxin; IEP:UniProtKB.
DR GO; GO:0009617; P:response to bacterium; IEP:UniProtKB.
DR GO; GO:0046898; P:response to cycloheximide; IEP:UniProtKB.
DR GO; GO:0009620; P:response to fungus; IEP:UniProtKB.
DR GO; GO:0001666; P:response to hypoxia; IEP:UniProtKB.
DR GO; GO:0009624; P:response to nematode; IEP:UniProtKB.
DR GO; GO:0006979; P:response to oxidative stress; IEP:UniProtKB.
DR GO; GO:1902074; P:response to salt; IEP:UniProtKB.
DR GO; GO:0010272; P:response to silver ion; IEP:UniProtKB.
DR GO; GO:0009414; P:response to water deprivation; IEP:UniProtKB.
DR GO; GO:0009611; P:response to wounding; IEP:UniProtKB.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR044716; LEUNIG-like.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR44376; PTHR44376; 2.
DR Pfam; PF08513; LisH; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00667; LisH; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Developmental protein; Differentiation; Flowering;
KW Nucleus; Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation; WD repeat.
FT CHAIN 1..931
FT /note="Transcriptional corepressor LEUNIG"
FT /id="PRO_0000051069"
FT DOMAIN 8..40
FT /note="LisH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT REPEAT 641..679
FT /note="WD 1"
FT REPEAT 683..721
FT /note="WD 2"
FT REPEAT 726..765
FT /note="WD 3"
FT REPEAT 769..804
FT /note="WD 4"
FT REPEAT 808..845
FT /note="WD 5"
FT REPEAT 852..890
FT /note="WD 6"
FT REPEAT 893..931
FT /note="WD 7"
FT REGION 1..88
FT /note="Required for SEU-binding"
FT REGION 149..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 404
FT /note="T -> S (in Ref. 1; AAG32022)"
FT /evidence="ECO:0000305"
FT CONFLICT 454
FT /note="N -> H (in Ref. 1; AAG32022)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 931 AA; 102233 MW; 7CB879744496A8AA CRC64;
MSQTNWEADK MLDVYIHDYL VKRDLKATAQ AFQAEGKVSS DPVAIDAPGG FLFEWWSVFW
DIFIARTNEK HSEVAASYIE TQMIKAREQQ LQQSQHPQVS QQQQQQQQQQ IQMQQLLLQR
AQQQQQQQQQ QHHHHQQQQQ QQQQQQQQQQ QQQQQHQNQP PSQQQQQQST PQHQQQPTPQ
QQPQRRDGSH LANGSANGLV GNNSEPVMRQ NPGSGSSLAS KAYEERVKMP TQRESLDEAA
MKRFGDNVGQ LLDPSHASIL KSAAASGQPA GQVLHSTSGG MSPQVQTRNQ QLPGSAVDIK
SEINPVLTPR TAVPEGSLIG IPGSNQGSNN LTLKGWPLTG FDQLRSGLLQ QQKPFMQSQS
FHQLNMLTPQ HQQQLMLAQQ NLNSQSVSEE NRRLKMLLNN RSMTLGKDGL GSSVGDVLPN
VGSSLQPGGS LLPRGDTDML LKLKMALLQQ QQQNQQQGGG NPPQPQPQPQ PLNQLALTNP
QPQSSNHSIH QQEKLGGGGS ITMDGSISNS FRGNEQVLKN QSGRKRKQPV SSSGPANSSG
TANTAGPSPS SAPSTPSTHT PGDVISMPNL PHSGGSSKSM MMFGTEGTGT LTSPSNQLAD
MDRFVEDGSL DDNVESFLSQ EDGDQRDAVT RCMDVSKGFT FTEVNSVRAS TTKVTCCHFS
SDGKMLASAG HDKKAVLWYT DTMKPKTTLE EHTAMITDIR FSPSQLRLAT SSFDKTVRVW
DADNKGYSLR TFMGHSSMVT SLDFHPIKDD LICSCDNDNE IRYWSINNGS CTRVYKGGST
QIRFQPRVGK YLAASSANLV NVLDVETQAI RHSLQGHANP INSVCWDPSG DFLASVSEDM
VKVWTLGTGS EGECVHELSC NGNKFQSCVF HPAYPSLLVI GCYQSLELWN MSENKTMTLP
AHEGLITSLA VSTATGLVAS ASHDKLVKLW K
