ID   LEUO_SALTY              Reviewed;         314 AA.
AC   P46924;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   13-DEC-2001, sequence version 2.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Probable HTH-type transcriptional regulator LeuO;
GN   Name=leuO; OrderedLocusNames=STM0115;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-75.
RX   PubMed=3519576; DOI=10.1128/jb.166.3.1113-1117.1986;
RA   Haughn G.W., Wessler S.R., Gemmill R.M., Calvo J.M.;
RT   "High A + T content conserved in DNA sequences upstream of leuABCD in
RT   Escherichia coli and Salmonella typhimurium.";
RL   J. Bacteriol. 166:1113-1117(1986).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB02429.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AE006468; AAL19079.1; -; Genomic_DNA.
DR   EMBL; M12892; AAB02429.1; ALT_FRAME; Genomic_DNA.
DR   PIR; B29846; B29846.
DR   RefSeq; NP_459120.1; NC_003197.2.
DR   RefSeq; WP_001115420.1; NC_003197.2.
DR   AlphaFoldDB; P46924; -.
DR   SMR; P46924; -.
DR   STRING; 99287.STM0115; -.
DR   PaxDb; P46924; -.
DR   EnsemblBacteria; AAL19079; AAL19079; STM0115.
DR   GeneID; 1251633; -.
DR   KEGG; stm:STM0115; -.
DR   PATRIC; fig|99287.12.peg.120; -.
DR   HOGENOM; CLU_039613_39_0_6; -.
DR   OMA; ICSPLDI; -.
DR   PhylomeDB; P46924; -.
DR   BioCyc; SENT99287:STM0115-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0032993; C:protein-DNA complex; IPI:CollecTF.
DR   GO; GO:0001216; F:DNA-binding transcription activator activity; IPI:CollecTF.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:CollecTF.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEP:CollecTF.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..314
FT                   /note="Probable HTH-type transcriptional regulator LeuO"
FT                   /id="PRO_0000105661"
FT   DOMAIN          22..79
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        39..58
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   CONFLICT        61
FT                   /note="K -> V (in Ref. 2; AAB02429)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        67
FT                   /note="E -> V (in Ref. 2; AAB02429)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        75
FT                   /note="G -> I (in Ref. 2; AAB02429)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   314 AA;  35716 MW;  FE98804B7E338810 CRC64;
     MPEVKTEKPH LLDMGKPQLR MVDLNLLTVF DAVMQEQNIT RAAHTLGMSQ PAVSNAVARL
     KVMFNDELFV RYGRGIQPTA RAFQLFGSVR QALQLVQNEL PGSGFEPTSS ERVFNLCVCS
     PLDNILTSQI YNRVEKIAPN IHVVFKASLN QNTEHQLRYQ ETEFVISYEE FRRPEFTSVP
     LFKDEMVLVA SRKHPRISGP LLEGDVYNEQ HAVVSLDRYA SFSQPWYDTP DKQSSVAYQG
     MALISVLNVV SQTHLVAIAP RWLAEEFAES LDLQILPLPL KLNSRTCYLS WHEAAGRDKG
     HQWMEDLLVS VCKR