ID   LEVI_XENLA              Reviewed;          88 AA.
AC   P13684;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Prolevitide;
DE   Contains:
DE     RecName: Full=Amphipathic peptide;
DE   Contains:
DE     RecName: Full=Levitide;
DE   Flags: Precursor;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PYROGLUTAMATE FORMATION AT GLN-74, PROTEIN
RP   SEQUENCE OF 74-87, AND AMIDATION AT GLN-87.
RC   TISSUE=Skin, and Skin secretion;
RX   PubMed=2830279; DOI=10.1016/s0021-9258(18)69068-4;
RA   Poulter L., Terry A.S., Williams D.H., Giovannini M.G., Moore C.H.,
RA   Gibson B.W.;
RT   "Levitide, a neurohormone-like peptide from the skin of Xenopus laevis.
RT   Peptide and peptide precursor cDNA sequences.";
RL   J. Biol. Chem. 263:3279-3283(1988).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
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DR   EMBL; M18681; AAA49899.1; -; mRNA.
DR   PIR; A28056; A28056.
DR   RefSeq; NP_001079112.1; NM_001085643.1.
DR   RefSeq; XP_018097848.1; XM_018242359.1.
DR   AlphaFoldDB; P13684; -.
DR   SMR; P13684; -.
DR   TCDB; 1.C.16.1.4; the magainin (magainin) family.
DR   GeneID; 373645; -.
DR   KEGG; xla:373645; -.
DR   CTD; 373645; -.
DR   Xenbase; XB-GENE-6252880; levi.2.L.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 373645; Expressed in zone of skin and 7 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Direct protein sequencing; Hormone;
KW   Neuropeptide; Pyrrolidone carboxylic acid; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..88
FT                   /note="Prolevitide"
FT                   /id="PRO_0000010674"
FT   PEPTIDE         39..63
FT                   /note="Amphipathic peptide"
FT                   /id="PRO_0000010675"
FT   PEPTIDE         74..87
FT                   /note="Levitide"
FT                   /id="PRO_0000010676"
FT   MOD_RES         74
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:2830279"
FT   MOD_RES         87
FT                   /note="Glutamine amide"
FT                   /evidence="ECO:0000269|PubMed:2830279"
SQ   SEQUENCE   88 AA;  9590 MW;  36A1E2B40D9B593E CRC64;
     MYKGIFLCVL FAVICANSLA KPSSDADEDN DEVERYVRGW ASKIGQTLGK IAKVGLQGLM
     QPKREAMLRS AEAQGMIGTL TSKRIKQG