LEXM_HUMAN
ID LEXM_HUMAN Reviewed; 418 AA.
AC Q3ZCV2; B7WPL2; Q8N7Y9;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 4.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Lymphocyte expansion molecule {ECO:0000303|PubMed:25883318};
GN Name=LEXM {ECO:0000312|HGNC:HGNC:26854};
GN Synonyms=LEM {ECO:0000303|PubMed:25883318}; ORFNames=C1orf177;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT CYS-126.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP CYS-126.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP RETRACTED PAPER.
RX PubMed=25883318; DOI=10.1126/science.aaa7516;
RA Okoye I., Wang L., Pallmer K., Richter K., Ichimura T., Haas R., Crouse J.,
RA Choi O., Heathcote D., Lovo E., Mauro C., Abdi R., Oxenius A.,
RA Rutschmann S., Ashton-Rickardt P.G.;
RT "T cell metabolism. The protein LEM promotes CD8+ T cell immunity through
RT effects on mitochondrial respiration.";
RL Science 348:995-1001(2015).
RN [5]
RP RETRACTION NOTICE OF PUBMED:25883318.
RX PubMed=27980177; DOI=10.1126/science.aal5242;
RA Sills J., Berg J.;
RL Science 354:1385-1385(2016).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3ZCV2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3ZCV2-2; Sequence=VSP_027294;
CC -!- CAUTION: Was reported to promote CD8+ T cell immunity through effects
CC on mitochondrial respiration (PubMed:25883318). However, the
CC corresponding article has been retracted (PubMed:27980177).
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DR EMBL; AK097520; BAC05087.1; -; mRNA.
DR EMBL; AC096536; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF495955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC039109; AAH39109.1; -; mRNA.
DR EMBL; BC064142; AAH64142.1; -; mRNA.
DR CCDS; CCDS44153.1; -. [Q3ZCV2-1]
DR CCDS; CCDS599.1; -. [Q3ZCV2-2]
DR RefSeq; NP_001104003.1; NM_001110533.1. [Q3ZCV2-1]
DR RefSeq; NP_689820.2; NM_152607.2. [Q3ZCV2-2]
DR AlphaFoldDB; Q3ZCV2; -.
DR BioGRID; 127877; 2.
DR STRING; 9606.ENSP00000360320; -.
DR iPTMnet; Q3ZCV2; -.
DR PhosphoSitePlus; Q3ZCV2; -.
DR BioMuta; LEXM; -.
DR DMDM; 223590240; -.
DR EPD; Q3ZCV2; -.
DR MassIVE; Q3ZCV2; -.
DR PaxDb; Q3ZCV2; -.
DR PeptideAtlas; Q3ZCV2; -.
DR PRIDE; Q3ZCV2; -.
DR ProteomicsDB; 61917; -. [Q3ZCV2-1]
DR ProteomicsDB; 61918; -. [Q3ZCV2-2]
DR Antibodypedia; 49963; 138 antibodies from 19 providers.
DR DNASU; 163747; -.
DR Ensembl; ENST00000358193.7; ENSP00000350924.3; ENSG00000162398.12. [Q3ZCV2-2]
DR Ensembl; ENST00000371273.4; ENSP00000360320.3; ENSG00000162398.12. [Q3ZCV2-1]
DR GeneID; 163747; -.
DR KEGG; hsa:163747; -.
DR MANE-Select; ENST00000371273.4; ENSP00000360320.3; NM_001110533.2; NP_001104003.1.
DR UCSC; uc001cya.5; human. [Q3ZCV2-1]
DR CTD; 163747; -.
DR DisGeNET; 163747; -.
DR GeneCards; LEXM; -.
DR HGNC; HGNC:26854; LEXM.
DR HPA; ENSG00000162398; Group enriched (esophagus, testis, vagina).
DR MIM; 616446; gene.
DR neXtProt; NX_Q3ZCV2; -.
DR OpenTargets; ENSG00000162398; -.
DR PharmGKB; PA142672425; -.
DR VEuPathDB; HostDB:ENSG00000162398; -.
DR eggNOG; KOG4087; Eukaryota.
DR GeneTree; ENSGT00390000015471; -.
DR HOGENOM; CLU_053450_0_0_1; -.
DR InParanoid; Q3ZCV2; -.
DR OMA; PFTKGKC; -.
DR OrthoDB; 826582at2759; -.
DR PhylomeDB; Q3ZCV2; -.
DR TreeFam; TF329164; -.
DR PathwayCommons; Q3ZCV2; -.
DR BioGRID-ORCS; 163747; 16 hits in 1039 CRISPR screens.
DR ChiTaRS; LEXM; human.
DR GenomeRNAi; 163747; -.
DR Pharos; Q3ZCV2; Tbio.
DR PRO; PR:Q3ZCV2; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q3ZCV2; protein.
DR Bgee; ENSG00000162398; Expressed in esophagus squamous epithelium and 48 other tissues.
DR Genevisible; Q3ZCV2; HS.
DR InterPro; IPR033557; LEXM.
DR PANTHER; PTHR34914; PTHR34914; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..418
FT /note="Lymphocyte expansion molecule"
FT /id="PRO_0000297585"
FT VAR_SEQ 396..418
FT /note="ERITPFTKGKCPPTVDYNSDPTP -> IRLFCWKGLEVINFGLSPM (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027294"
FT VARIANT 126
FT /note="G -> C (in dbSNP:rs9782980)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_034645"
FT VARIANT 205
FT /note="H -> Y (in dbSNP:rs600499)"
FT /id="VAR_054410"
FT CONFLICT 122
FT /note="K -> R (in Ref. 3; AAH39109)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 418 AA; 47583 MW; A7B9DFB970B73C2C CRC64;
MRESQDAAGA HGWNRVGSTA TKWFTGAPFG VQSHRFDISA VYPNWKKFST FTEAPYSTRY
STQVSHIGPG TYSSKETCFS KKKLMKEVDT GWAKAQEATR LTQLPHFQYQ AIMKEKRLKE
QKLGPGSYNL KDFLEQLREK PCSTRGLLSS GEVRFRGLTG NYYPGPGNYG EKGNPYTKLE
ENAWNRSHSE GLMCRMSNKP HPRPHQGSGL GPGTYFFKSD LETYVARSVG TRGPYDTFSG
DRSKPLPYGH YSMQKKKPRE LMNFKSFVEE LNSHHNKKHG VFSKLPRNPK TPTERIYWAN
LSQCPRTLAT SGPSFWLPQE KKCKPVNQPP FLLTSKGSGA KACQMIMGSW NPVGVGRYLN
TWLMETKDRR QRYRSLFLSG SKRYLSDLAR DMLMQERITP FTKGKCPPTV DYNSDPTP
