ID   LEXM_MOUSE              Reviewed;         414 AA.
AC   A2AVQ5; A2AVQ4; Q7TPM4;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Lymphocyte expansion molecule {ECO:0000303|PubMed:25883318};
GN   Name=Lexm {ECO:0000312|MGI:MGI:2681853};
GN   Synonyms=Lem {ECO:0000303|PubMed:25883318};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   RETRACTED PAPER.
RX   PubMed=25883318; DOI=10.1126/science.aaa7516;
RA   Okoye I., Wang L., Pallmer K., Richter K., Ichimura T., Haas R., Crouse J.,
RA   Choi O., Heathcote D., Lovo E., Mauro C., Abdi R., Oxenius A.,
RA   Rutschmann S., Ashton-Rickardt P.G.;
RT   "T cell metabolism. The protein LEM promotes CD8+ T cell immunity through
RT   effects on mitochondrial respiration.";
RL   Science 348:995-1001(2015).
RN   [4]
RP   RETRACTION NOTICE OF PUBMED:25883318.
RX   PubMed=27980177; DOI=10.1126/science.aal5242;
RA   Sills J., Berg J.;
RL   Science 354:1385-1385(2016).
CC   -!- CAUTION: Was reported to promote CD8+ T cell immunity through effects
CC       on mitochondrial respiration (PubMed:25883318). However, the
CC       corresponding article has been retracted (PubMed:27980177).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH55111.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL929585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC055111; AAH55111.1; ALT_INIT; mRNA.
DR   CCDS; CCDS51252.1; -.
DR   RefSeq; NP_899005.2; NM_183182.3.
DR   AlphaFoldDB; A2AVQ5; -.
DR   DIP; DIP-61652N; -.
DR   STRING; 10090.ENSMUSP00000102400; -.
DR   PhosphoSitePlus; A2AVQ5; -.
DR   PaxDb; A2AVQ5; -.
DR   PRIDE; A2AVQ5; -.
DR   ProteomicsDB; 291939; -.
DR   Antibodypedia; 49963; 138 antibodies from 19 providers.
DR   DNASU; 242602; -.
DR   Ensembl; ENSMUST00000067387; ENSMUSP00000066732; ENSMUSG00000054362.
DR   Ensembl; ENSMUST00000106788; ENSMUSP00000102400; ENSMUSG00000054362.
DR   Ensembl; ENSMUST00000189032; ENSMUSP00000139868; ENSMUSG00000054362.
DR   GeneID; 242602; -.
DR   KEGG; mmu:242602; -.
DR   UCSC; uc012dhz.1; mouse.
DR   CTD; 163747; -.
DR   MGI; MGI:2681853; Lexm.
DR   VEuPathDB; HostDB:ENSMUSG00000054362; -.
DR   eggNOG; KOG4087; Eukaryota.
DR   GeneTree; ENSGT00390000015471; -.
DR   HOGENOM; CLU_053450_0_0_1; -.
DR   InParanoid; A2AVQ5; -.
DR   OMA; PFTKGKC; -.
DR   OrthoDB; 826582at2759; -.
DR   PhylomeDB; A2AVQ5; -.
DR   TreeFam; TF329164; -.
DR   BioGRID-ORCS; 242602; 2 hits in 39 CRISPR screens.
DR   ChiTaRS; Lexm; mouse.
DR   PRO; PR:A2AVQ5; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; A2AVQ5; protein.
DR   Bgee; ENSMUSG00000054362; Expressed in testis and 32 other tissues.
DR   ExpressionAtlas; A2AVQ5; baseline and differential.
DR   InterPro; IPR033557; LEXM.
DR   PANTHER; PTHR34914; PTHR34914; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..414
FT                   /note="Lymphocyte expansion molecule"
FT                   /id="PRO_0000297586"
FT   CONFLICT        165
FT                   /note="N -> D (in Ref. 2; AAH55111)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   414 AA;  47584 MW;  251EF0F88B6E80C3 CRC64;
     MRPRTHGAPP RNIMSTIPKW FKGAPFGVQS HRFDVSAVYP NQKKFSTFTE APYSRHHSVE
     LSHIGPGTYN SKDTCFSKKF LEQKLGSGWS QAHEATRLTQ LPHFHYQAIK KEKEQQVHKR
     GPGSYNIKDF ITELQKKPQS KRGLLSSGET RFRGFIGNYY PGPGNYGEKG NPYTQLEEKA
     WNRSHSDGLM CRVSNKPPLF HQGSGLGPGT YTIKSDLETF VKKSTGNRGP YDIFSGERSS
     PLPYGHYSVQ KMKPKELTDY KSFLDEMNSQ HKKKQGVFSK YPRDPKHPTE RIFWTTLSQC
     PKNMDIAGPG SWLPHETEQK HVNRPPFLLA SKRCGLKAYQ MILGTWNPVG VGRYLNTTLM
     ESIDRRQRYR SLYMSEPKRY LQDLTRDRLM QKRITPITKG KCRPTVDYNS DPTP