ID   LF2_EBVA8               Reviewed;         429 AA.
AC   P0C726; Q99306;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   03-AUG-2022, entry version 30.
DE   RecName: Full=Protein LF2;
GN   Name=LF2;
OS   Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=82830;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Raji;
RX   PubMed=16490228; DOI=10.1016/j.virol.2006.01.015;
RA   Dolan A., Addison C., Gatherer D., Davison A.J., McGeoch D.J.;
RT   "The genome of Epstein-Barr virus type 2 strain AG876.";
RL   Virology 350:164-170(2006).
CC   -!- FUNCTION: Prevents the establishment of cellular antiviral state by
CC       blocking the cellular IRF7-mediated innate immunity. May also inhibit
CC       viral replication by modulating BRLF1 activity (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host IRF7; this interaction inhibits IRF7
CC       dimerization, thereby altering its function in immunity. Interacts with
CC       BRLF1; this interaction modulates BRLF1 function (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the epstein-barr virus LF2 family.
CC       {ECO:0000305}.
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DR   EMBL; DQ279927; ABB89283.1; -; Genomic_DNA.
DR   PIR; S27924; S27924.
DR   RefSeq; YP_001129504.1; NC_009334.1.
DR   RefSeq; YP_401708.1; NC_007605.1.
DR   SMR; P0C726; -.
DR   DNASU; 3783748; -.
DR   GeneID; 3783748; -.
DR   GeneID; 5176211; -.
DR   KEGG; vg:3783748; -.
DR   KEGG; vg:5176211; -.
DR   Proteomes; UP000007639; Genome.
DR   InterPro; IPR006882; Herpes_Orf11.
DR   Pfam; PF04797; Herpes_ORF11; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Interferon antiviral system evasion;
KW   Reference proteome.
FT   CHAIN           1..429
FT                   /note="Protein LF2"
FT                   /id="PRO_0000382451"
SQ   SEQUENCE   429 AA;  48422 MW;  B3D085D233AF6251 CRC64;
     MAEAYPGGAH AALASRRSSF RNSLRRLRPT EKPDTSFMRG VWKYEIFPSY VRVTNKQVLQ
     LDAQCQELPP CPSVGQILSF KLPSFSFNTT TYGSRYFTVA FLFFGAEDNE VFLKPFFVMH
     SDQDIVLSVL NPRSLFIEKG KFTWYIVPIR LVKNPYLYLQ ILPGQSDIQL TRSCTQSGDK
     LNTSEPQIFL SGSPVTSQDE CLPYLLAQHT PPFLKSYARI HTFPGKVCPV NAIRRGKGYV
     RVSVDTPDLK REGPLNVKVG MTLLDDVIIA FRYNPYPKSH WRWDGESTDI RYFGSPVIIP
     PNFITELEYN NTYEAPLSSK ITAVVVSHSS NPVFYVYPQE WKPGQTLKLT VRNISNNPIT
     IVTGQSMAQA FFIYAGDPSI STIMRRYIQR QGCALTLPGN IVVESSSLPT FERINKTFNG
     NIVASEGTL