ID   LF2_EBVB9               Reviewed;         429 AA.
AC   P0C725; Q99306;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Protein LF2;
GN   Name=LF2;
OS   Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=10377;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=6087149; DOI=10.1038/310207a0;
RA   Baer R., Bankier A.T., Biggin M.D., Deininger P.L., Farrell P.J.,
RA   Gibson T.J., Hatfull G., Hudson G.S., Satchwell S.C., Seguin C.,
RA   Tuffnell P.S., Barrell B.G.;
RT   "DNA sequence and expression of the B95-8 Epstein-Barr virus genome.";
RL   Nature 310:207-211(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Raji;
RX   PubMed=2171209; DOI=10.1016/0042-6822(90)90302-8;
RA   Parker B.D., Bankier A., Satchwell S., Barrell B., Farrell P.J.;
RT   "Sequence and transcription of Raji Epstein-Barr virus DNA spanning the
RT   B95-8 deletion region.";
RL   Virology 179:339-346(1990).
RN   [3]
RP   INTERACTION WITH BRLF1.
RX   PubMed=18562535; DOI=10.1128/jvi.00315-08;
RA   Calderwood M.A., Holthaus A.M., Johannsen E.;
RT   "The Epstein-Barr virus LF2 protein inhibits viral replication.";
RL   J. Virol. 82:8509-8519(2008).
RN   [4]
RP   INTERACTION WITH HOST IRF7.
RX   PubMed=18987133; DOI=10.1128/jvi.00602-08;
RA   Wu L., Fossum E., Joo C.H., Inn K.S., Shin Y.C., Johannsen E.,
RA   Hutt-Fletcher L.M., Hass J., Jung J.U.;
RT   "Epstein-Barr virus LF2: an antagonist to type I interferon.";
RL   J. Virol. 83:1140-1146(2009).
CC   -!- FUNCTION: Prevents the establishment of cellular antiviral state by
CC       blocking the cellular IRF7-mediated innate immunity. May also inhibit
CC       viral replication by modulating BRLF1 activity.
CC   -!- SUBUNIT: Interacts with host IRF7; this interaction inhibits IRF7
CC       dimerization, thereby altering its function in immunity. Interacts with
CC       BRLF1. {ECO:0000269|PubMed:18562535, ECO:0000269|PubMed:18987133}.
CC   -!- SIMILARITY: Belongs to the epstein-barr virus LF2 family.
CC       {ECO:0000305}.
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DR   EMBL; M35547; AAA45897.1; -; Genomic_DNA.
DR   EMBL; AJ507799; CAD53458.1; -; Genomic_DNA.
DR   PIR; S27924; S27924.
DR   RefSeq; YP_401708.1; NC_007605.1.
DR   SMR; P0C725; -.
DR   IntAct; P0C725; 3.
DR   MINT; P0C725; -.
DR   PRIDE; P0C725; -.
DR   DNASU; 3783748; -.
DR   GeneID; 3783748; -.
DR   KEGG; vg:3783748; -.
DR   SIGNOR; P0C725; -.
DR   Proteomes; UP000153037; Genome.
DR   GO; GO:0010629; P:negative regulation of gene expression; IDA:CACAO.
DR   InterPro; IPR006882; Herpes_Orf11.
DR   Pfam; PF04797; Herpes_ORF11; 1.
PE   1: Evidence at protein level;
KW   Host-virus interaction; Interferon antiviral system evasion;
KW   Reference proteome.
FT   CHAIN           1..429
FT                   /note="Protein LF2"
FT                   /id="PRO_0000382450"
SQ   SEQUENCE   429 AA;  48422 MW;  B3D085D233AF6251 CRC64;
     MAEAYPGGAH AALASRRSSF RNSLRRLRPT EKPDTSFMRG VWKYEIFPSY VRVTNKQVLQ
     LDAQCQELPP CPSVGQILSF KLPSFSFNTT TYGSRYFTVA FLFFGAEDNE VFLKPFFVMH
     SDQDIVLSVL NPRSLFIEKG KFTWYIVPIR LVKNPYLYLQ ILPGQSDIQL TRSCTQSGDK
     LNTSEPQIFL SGSPVTSQDE CLPYLLAQHT PPFLKSYARI HTFPGKVCPV NAIRRGKGYV
     RVSVDTPDLK REGPLNVKVG MTLLDDVIIA FRYNPYPKSH WRWDGESTDI RYFGSPVIIP
     PNFITELEYN NTYEAPLSSK ITAVVVSHSS NPVFYVYPQE WKPGQTLKLT VRNISNNPIT
     IVTGQSMAQA FFIYAGDPSI STIMRRYIQR QGCALTLPGN IVVESSSLPT FERINKTFNG
     NIVASEGTL