ID   LF2_EBVG                Reviewed;         236 AA.
AC   Q3KSP5;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Protein LF2;
GN   Name=LF2;
OS   Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=10376;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Raji;
RX   PubMed=16306603; DOI=10.1128/jvi.79.24.15323-15330.2005;
RA   Zeng M.-S., Li D.-J., Liu Q.-L., Song L.-B., Li M.-Z., Zhang R.-H.,
RA   Yu X.-J., Wang H.-M., Ernberg I., Zeng Y.-X.;
RT   "Genomic sequence analysis of Epstein-Barr virus strain GD1 from a
RT   nasopharyngeal carcinoma patient.";
RL   J. Virol. 79:15323-15330(2005).
CC   -!- FUNCTION: Prevents the establishment of cellular antiviral state by
CC       blocking the cellular IRF7-mediated innate immunity. May also inhibit
CC       viral replication by modulating BRLF1 activity (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with host IRF7; this interaction inhibits IRF7
CC       dimerization, thereby altering its function in immunity. Interacts with
CC       BRLF1; this interaction modulates BRLF1 function (By similarity).
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q3KSP5; Q3KSP5: LF2; NbExp=2; IntAct=EBI-2621084, EBI-2621084;
CC       Q3KSP5; P03209: BRLF1; Xeno; NbExp=2; IntAct=EBI-2621084, EBI-2621080;
CC   -!- SIMILARITY: Belongs to the epstein-barr virus LF2 family.
CC       {ECO:0000305}.
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DR   EMBL; AY961628; ABA06394.1; -; Genomic_DNA.
DR   IntAct; Q3KSP5; 1.
DR   Proteomes; UP000007641; Genome.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   InterPro; IPR006882; Herpes_Orf11.
DR   Pfam; PF04797; Herpes_ORF11; 1.
PE   1: Evidence at protein level;
KW   Host-virus interaction; Interferon antiviral system evasion.
FT   CHAIN           1..236
FT                   /note="Protein LF2"
FT                   /id="PRO_0000382452"
SQ   SEQUENCE   236 AA;  26517 MW;  58D4B6194AE7CA93 CRC64;
     MAEAYPGGAH AALASRRSSF RNSLRRLRPT EKPDTSFMRG VWKYEIFPSY VRVTNKQVLQ
     LDAQCQELPP CPSVGQILSF KLPSFSFNTT TYGSRYFTVA FLFFGAEDNE VFLKPFFVMH
     SAPGHRAKRP ESAQPVHRER EVYLVHCAHQ IGQEPLPLPA DSARAERHSA DTLLHPERGQ
     AKHQRAPDLP QWLSRHQPGR VPALPAGAAH APISKVIRPY SHIPGEGMSG QRHTPR