ID   LFG1_BOVIN              Reviewed;         366 AA.
AC   Q32L53;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Protein lifeguard 1;
DE   AltName: Full=Glutamate [NMDA] receptor-associated protein 1;
DE   AltName: Full=NMDA receptor glutamate-binding subunit;
GN   Name=GRINA; Synonyms=LFG1, NMDARA1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potential apoptotic regulator. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BI1 family. LFG subfamily. {ECO:0000305}.
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DR   EMBL; BC109761; AAI09762.1; -; mRNA.
DR   RefSeq; NP_001032682.1; NM_001037593.1.
DR   AlphaFoldDB; Q32L53; -.
DR   STRING; 9913.ENSBTAP00000000410; -.
DR   BindingDB; Q32L53; -.
DR   PaxDb; Q32L53; -.
DR   PRIDE; Q32L53; -.
DR   Ensembl; ENSBTAT00000000410; ENSBTAP00000000410; ENSBTAG00000000312.
DR   Ensembl; ENSBTAT00000084417; ENSBTAP00000062106; ENSBTAG00000000312.
DR   GeneID; 510225; -.
DR   KEGG; bta:510225; -.
DR   CTD; 2907; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000312; -.
DR   VGNC; VGNC:29651; GRINA.
DR   eggNOG; KOG2322; Eukaryota.
DR   GeneTree; ENSGT01050000244890; -.
DR   HOGENOM; CLU_058671_3_0_1; -.
DR   InParanoid; Q32L53; -.
DR   OMA; YYVSYAF; -.
DR   OrthoDB; 1290306at2759; -.
DR   TreeFam; TF319996; -.
DR   Proteomes; UP000009136; Chromosome 14.
DR   Bgee; ENSBTAG00000000312; Expressed in retina and 104 other tissues.
DR   ExpressionAtlas; Q32L53; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl.
DR   GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
DR   GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IBA:GO_Central.
DR   GO; GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   InterPro; IPR006214; Bax_inhibitor_1-related.
DR   PANTHER; PTHR23291; PTHR23291; 1.
DR   Pfam; PF01027; Bax1-I; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..366
FT                   /note="Protein lifeguard 1"
FT                   /id="PRO_0000314438"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..113
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   366 AA;  40232 MW;  1541BF4CE97F5CA2 CRC64;
     MSHEKSFLVS GDSYPPPNPG YPGGPQPSMA PYPGAPYPQA PFQPSPYGQP GYPQGPSPYP
     QGGYPQGPYP PGGYPQGPYP PGGYPQGPYP PGGYPQGPYP QSPFPPNPYG QPQAFPAQDP
     GSPHHGNYHE EGPPSYYDNQ DFPATNWDDK SIRQAFIRKV FLVLTLQLSV TLSTVAVFTF
     VGEVKGFVRE NVWTYYVSYA IFFVSLIVLS CCGDFRRKHP WNLVALSILT VSLSYMVGMI
     ASFYNTEAVI MAVGITTTVC FTVVIFSMQT RYDFTSCVGV LLVSVVVLIL FAILCIFIRS
     RVLEIVYASL GALLFTCFLA VDTQLLLGNK QLSLSPEEYV FAALNLYTDI INIFLYILTI
     IGRAKE