LFG1_HUMAN
ID LFG1_HUMAN Reviewed; 371 AA.
AC Q7Z429; B3KXM7; O43836; Q8IVW7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Protein lifeguard 1;
DE AltName: Full=Glutamate [NMDA] receptor-associated protein 1;
DE AltName: Full=NMDA receptor glutamate-binding subunit;
DE AltName: Full=Putative MAPK-activating protein PM02;
DE AltName: Full=Transmembrane BAX inhibitor motif-containing protein 3;
GN Name=GRINA; Synonyms=LFG1, NMDARA1, TMBIM3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=12761501; DOI=10.1038/sj.onc.1206406;
RA Matsuda A., Suzuki Y., Honda G., Muramatsu S., Matsuzaki O., Nagano Y.,
RA Doi T., Shimotohno K., Harada T., Nishida E., Hayashi H., Sugano S.;
RT "Large-scale identification and characterization of human genes that
RT activate NF-kappaB and MAPK signaling pathways.";
RL Oncogene 22:3307-3318(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASN-107.
RC TISSUE=Pancreas, and Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 218-371.
RC TISSUE=Liver;
RA Won M., Moon K.-M., Lee C.-E., Yoo H.S.;
RL Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP IDENTIFICATION.
RX PubMed=8406459; DOI=10.1006/geno.1993.1311;
RA Collins C., Duff C., Duncan A.M.V., Planells-Cases R., Sun W.,
RA Norremolle A., Michaelis E., Montal M., Worton R., Hayden M.R.;
RT "Mapping of the human NMDA receptor subunit (NMDAR1) and the proposed NMDA
RT receptor glutamate-binding subunit (NMDARA1) to chromosomes 9q34.3 and
RT chromosome 8, respectively.";
RL Genomics 17:237-239(1993).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19784873; DOI=10.1007/s10495-009-0402-2;
RA Hu L., Smith T.F., Goldberger G.;
RT "LFG: a candidate apoptosis regulatory gene family.";
RL Apoptosis 14:1255-1265(2009).
CC -!- FUNCTION: Potential apoptotic regulator.
CC -!- INTERACTION:
CC Q7Z429; Q01740: FMO1; NbExp=3; IntAct=EBI-2832909, EBI-12701460;
CC Q7Z429; Q6P531: GGT6; NbExp=3; IntAct=EBI-2832909, EBI-2868927;
CC Q7Z429; Q8TED1: GPX8; NbExp=3; IntAct=EBI-2832909, EBI-11721746;
CC Q7Z429; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-2832909, EBI-1048945;
CC Q7Z429; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-2832909, EBI-11962084;
CC Q7Z429; Q01085-2: TIAL1; NbExp=3; IntAct=EBI-2832909, EBI-11064654;
CC Q7Z429; Q9NWH2: TMEM242; NbExp=3; IntAct=EBI-2832909, EBI-10315004;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the BI1 family. LFG subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB94292.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB097026; BAC77379.1; -; mRNA.
DR EMBL; AK127640; BAG54539.1; -; mRNA.
DR EMBL; CH471416; EAW52305.1; -; Genomic_DNA.
DR EMBL; BC041788; AAH41788.2; -; mRNA.
DR EMBL; BC084553; AAH84553.1; -; mRNA.
DR EMBL; U44954; AAB94292.1; ALT_FRAME; mRNA.
DR CCDS; CCDS34961.1; -.
DR RefSeq; NP_000828.1; NM_000837.1.
DR RefSeq; NP_001009184.1; NM_001009184.1.
DR AlphaFoldDB; Q7Z429; -.
DR BioGRID; 109164; 11.
DR DIP; DIP-47262N; -.
DR IntAct; Q7Z429; 11.
DR MINT; Q7Z429; -.
DR STRING; 9606.ENSP00000314380; -.
DR TCDB; 1.A.14.3.14; the calcium transporter a (cata) (formerly the testis-enhanced gene transfer (tegt) family.
DR iPTMnet; Q7Z429; -.
DR PhosphoSitePlus; Q7Z429; -.
DR BioMuta; GRINA; -.
DR DMDM; 74738689; -.
DR EPD; Q7Z429; -.
DR MassIVE; Q7Z429; -.
DR PaxDb; Q7Z429; -.
DR PeptideAtlas; Q7Z429; -.
DR PRIDE; Q7Z429; -.
DR ProteomicsDB; 69135; -.
DR TopDownProteomics; Q7Z429; -.
DR Antibodypedia; 48337; 201 antibodies from 24 providers.
DR DNASU; 2907; -.
DR Ensembl; ENST00000313269.5; ENSP00000314380.5; ENSG00000178719.17.
DR Ensembl; ENST00000395068.9; ENSP00000378507.4; ENSG00000178719.17.
DR GeneID; 2907; -.
DR KEGG; hsa:2907; -.
DR MANE-Select; ENST00000395068.9; ENSP00000378507.4; NM_001009184.2; NP_001009184.1.
DR UCSC; uc003zan.2; human.
DR CTD; 2907; -.
DR DisGeNET; 2907; -.
DR GeneCards; GRINA; -.
DR HGNC; HGNC:4589; GRINA.
DR HPA; ENSG00000178719; Low tissue specificity.
DR MIM; 138251; gene.
DR neXtProt; NX_Q7Z429; -.
DR OpenTargets; ENSG00000178719; -.
DR PharmGKB; PA28985; -.
DR VEuPathDB; HostDB:ENSG00000178719; -.
DR eggNOG; KOG2322; Eukaryota.
DR GeneTree; ENSGT01050000244890; -.
DR HOGENOM; CLU_058671_3_0_1; -.
DR InParanoid; Q7Z429; -.
DR OMA; YYVSYAF; -.
DR OrthoDB; 1290306at2759; -.
DR PhylomeDB; Q7Z429; -.
DR TreeFam; TF319996; -.
DR PathwayCommons; Q7Z429; -.
DR SignaLink; Q7Z429; -.
DR BioGRID-ORCS; 2907; 8 hits in 1073 CRISPR screens.
DR ChiTaRS; GRINA; human.
DR GenomeRNAi; 2907; -.
DR Pharos; Q7Z429; Tbio.
DR PRO; PR:Q7Z429; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q7Z429; protein.
DR Bgee; ENSG00000178719; Expressed in left testis and 193 other tissues.
DR ExpressionAtlas; Q7Z429; baseline and differential.
DR Genevisible; Q7Z429; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0044325; F:transmembrane transporter binding; IEA:Ensembl.
DR GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR InterPro; IPR006214; Bax_inhibitor_1-related.
DR PANTHER; PTHR23291; PTHR23291; 1.
DR Pfam; PF01027; Bax1-I; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..371
FT /note="Protein lifeguard 1"
FT /id="PRO_0000314439"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..118
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 107
FT /note="S -> N (in dbSNP:rs17854152)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_037875"
FT CONFLICT 224
FT /note="H -> R (in Ref. 5; AAB94292)"
FT /evidence="ECO:0000305"
FT CONFLICT 317
FT /note="A -> P (in Ref. 5; AAB94292)"
FT /evidence="ECO:0000305"
FT CONFLICT 332..336
FT /note="LGNKQ -> REQA (in Ref. 5; AAB94292)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 371 AA; 41203 MW; 62E012DFB0E7DEEB CRC64;
MSHEKSFLVS GDNYPPPNPG YPGGPQPPMP PYAQPPYPGA PYPQPPFQPS PYGQPGYPHG
PSPYPQGGYP QGPYPQGGYP QGPYPQEGYP QGPYPQGGYP QGPYPQSPFP PNPYGQPQVF
PGQDPDSPQH GNYQEEGPPS YYDNQDFPAT NWDDKSIRQA FIRKVFLVLT LQLSVTLSTV
SVFTFVAEVK GFVRENVWTY YVSYAVFFIS LIVLSCCGDF RRKHPWNLVA LSVLTASLSY
MVGMIASFYN TEAVIMAVGI TTAVCFTVVI FSMQTRYDFT SCMGVLLVSM VVLFIFAILC
IFIRNRILEI VYASLGALLF TCFLAVDTQL LLGNKQLSLS PEEYVFAALN LYTDIINIFL
YILTIIGRAK E
