LFG1_MOUSE
ID LFG1_MOUSE Reviewed; 345 AA.
AC Q9ESF4; Q8CI25;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Protein lifeguard 1;
DE AltName: Full=Glutamate [NMDA] receptor-associated protein 1;
DE AltName: Full=NMDA receptor glutamate-binding subunit;
GN Name=Grina; Synonyms=Lag, Lfg1, Nmdara1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Goldberger O., Smith T., Minta J., Goldberger G.;
RT "Identification and phylogeny of a novel family of eukaryotic membrane
RT proteins related to a glutamate binding protein (GBP).";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N, FVB/N-3, and NMRI; TISSUE=Kidney, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19784873; DOI=10.1007/s10495-009-0402-2;
RA Hu L., Smith T.F., Goldberger G.;
RT "LFG: a candidate apoptosis regulatory gene family.";
RL Apoptosis 14:1255-1265(2009).
CC -!- FUNCTION: Potential apoptotic regulator. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the BI1 family. LFG subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF182040; AAG16897.1; -; mRNA.
DR EMBL; BC010802; AAH10802.1; -; mRNA.
DR EMBL; BC019157; AAH19157.1; -; mRNA.
DR EMBL; BC037667; AAH37667.2; -; mRNA.
DR CCDS; CCDS27563.1; -.
DR RefSeq; NP_075657.1; NM_023168.3.
DR RefSeq; XP_006521312.1; XM_006521249.3.
DR RefSeq; XP_006521313.1; XM_006521250.3.
DR RefSeq; XP_006521314.1; XM_006521251.3.
DR RefSeq; XP_011244011.1; XM_011245709.2.
DR AlphaFoldDB; Q9ESF4; -.
DR SMR; Q9ESF4; -.
DR STRING; 10090.ENSMUSP00000023225; -.
DR PhosphoSitePlus; Q9ESF4; -.
DR PaxDb; Q9ESF4; -.
DR PRIDE; Q9ESF4; -.
DR Antibodypedia; 48337; 201 antibodies from 24 providers.
DR DNASU; 66168; -.
DR Ensembl; ENSMUST00000023225; ENSMUSP00000023225; ENSMUSG00000022564.
DR GeneID; 66168; -.
DR KEGG; mmu:66168; -.
DR UCSC; uc007wjl.1; mouse.
DR CTD; 2907; -.
DR MGI; MGI:1913418; Grina.
DR VEuPathDB; HostDB:ENSMUSG00000022564; -.
DR eggNOG; KOG2322; Eukaryota.
DR GeneTree; ENSGT01050000244890; -.
DR HOGENOM; CLU_058671_3_0_1; -.
DR InParanoid; Q9ESF4; -.
DR OMA; YYVSYAF; -.
DR OrthoDB; 1290306at2759; -.
DR PhylomeDB; Q9ESF4; -.
DR TreeFam; TF319996; -.
DR BioGRID-ORCS; 66168; 2 hits in 75 CRISPR screens.
DR ChiTaRS; Grina; mouse.
DR PRO; PR:Q9ESF4; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9ESF4; protein.
DR Bgee; ENSMUSG00000022564; Expressed in granulocyte and 69 other tissues.
DR ExpressionAtlas; Q9ESF4; baseline and differential.
DR Genevisible; Q9ESF4; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
DR GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0044325; F:transmembrane transporter binding; IDA:MGI.
DR GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IDA:MGI.
DR GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IDA:MGI.
DR InterPro; IPR006214; Bax_inhibitor_1-related.
DR PANTHER; PTHR23291; PTHR23291; 1.
DR Pfam; PF01027; Bax1-I; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..345
FT /note="Protein lifeguard 1"
FT /id="PRO_0000314440"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..101
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 345 AA; 38408 MW; A76F722EB678A2F7 CRC64;
MSHEKSFLVS GDSYPPQNIV GPQAPMPPYV QAPYPGAPYP QAPFQPSPYG QPGYPHGPSP
YPQGGYPQGP YPQGGYPQGP YPQSPFPPNP YGQPPPFQDP GSPQHGNYQE EGPPSYYDNQ
DFPAVNWDKN IRQAFIRKVF LVLTLQLSVT LSTVAIFTFV GEVKGFVREN VWTYYVSYAI
FFISLIVLSC CGDFRRKHPW NLVALSILTV SLSYMVGMIA SFYNTEAVIM AVGITTAVCF
TVVIFSMQTR YDFTSCMGVL LVSVVVLFIF AILCIFIRNR ILEIVYASLG ALLFTCFLAV
DTQLLLGNKQ LSLSPEEYVF AALNLYTDII NIFLYILTII GRAKE
